Comparative neuropharmacological and Cytotoxic profiles of Alstonia scholaris (L.) and Mimusops elengi (L.) leaves

Sarkar, Kishore Kumar; Rahman, Md. Muzibar; Shahriar, Abdullah Al Ehsan; Mitra, Trina; Golder, Mimi; Zilani, Md. Nazmul Hasan; Biswas, Biswajit

doi:10.1007/s13596-020-00463-5

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Acute toxicity of plant extracts was evaluated using mice according to the method of Sarkar et al [21]. The mice were orally administrated with different concentrations of extracts (250, 500, 1000, 2000 mg/kg) and then kept under observations for 14 days to identify effects of extracts on behavioral patterns like alertness, locomotion, salivation, convulsions and potential changes in grip strength, pain response, even mortality.…”

Section: Acute Toxicity Evaluationmentioning

confidence: 99%

Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice

Biswas

Golder

Abid³

et al. 2021

Heliyon

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Introduction: Ceriops decandra (CD) and Ceriops tagal (CT) are two traditionally used mangrove plants widely distributed along the coastal areas of South Asia, Africa, South Pacific. In this study, we evaluated the diuretic potential of aerial roots of CD, CT and assessed the effectiveness of the plants' terpenoids enriched bioactive constituents against human carbonic anhydrase (hCA) enzyme through molecular docking. Materials and methods: Firstly, the acute toxicity of CD and CT was evaluated in mice. In vivo diuretic activity was then studied in mice and the volume of excreted urine was measured. The urine was further examined for pH, density and Na þ , K þ , Cl À concentrations. From this, the saluretic, natriuretic, kaliuretic and CAI (carbonic anhydrase inhibitory) activities were calculated. Finally, total terpenoid contents (TTC) of the plant extracts were quantified and the terpenoids previously reported from both CD and CT were docked against four hCA isoforms -hCAII, hCAIV, hCAXII and hCAXIV. Results: In the acute toxicity assessment, no sign of toxicity was found. In diuretic activity evaluation, both extracts displayed substantial increase in urine volume, with CD being at top. Concentrations of Na þ , K þ and Cl À were also upsurged at a high dose of treatment (500 mg/kg). Both extracts at 500 mg/kg dose demonstrated potent saluretic, natriuretic and CAI activity. The TTC of CD was significantly higher than CT. In molecular docking analysis, greater binding affinity against hCA isoforms was demonstrated by the terpenoids reported from CD. Conclusion: Aerial roots of both CD and CT possess substantial diuretic activity with an inhibitory effect on CA. Here, diuretic potential as well as the total terpenoid content of CD were much greater between the two.

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Section: Acute Toxicity Evaluationmentioning

confidence: 99%

Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice

Biswas

Golder

Abid³

et al. 2021

Heliyon

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“…The cytotoxic effect of NBOL and MBOL were evaluated by the brine shrimp lethality bioassay according to the methodology proposed by Sarkar et al, 2021 [ 27 ] with slight modification. In a tiny tank with sterile simulated seawater (Diluted 1 L of purified water with 38 g of iodine-free sea salt, then use 1 N NaOH to bring the pH to 8.5) and continuous aeration for 48 h, brine shrimp (Artemia salina) were hatched.…”

Section: Methodsmentioning

confidence: 99%

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

Sarkar,

Mitra,

Aktaruzzaman

et al. 2024

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“…To determine the toxicity of the extract, a brine shrimp lethality test was performed [20]. Firstly, Artemina salina eggs were hatched in an aquarium in simulated sea water.…”

Section: Brine Shrimp Lethality Bioassaymentioning

confidence: 99%

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

Rahman¹,

Zilani²,

Islam³

et al. 2021

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Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed to explore phytochemicals from the ethanol leaf extract of Gomphandra tetrandra (Wall.) Sleumer to identify the potential pharmacophore(s) in the treatment of neurological disorders. The chemical compounds of the experimental plant were identified through GC-MS analysis. In-vitro antioxidant activity was assessed using different methods. Furthermore, in-vivo neurological activity was assessed in Swiss-albino mice. Computer-aided analysis was appraised to determine the best-fit phytoconstituent of a total of fifteen identified compounds in the experimental plant extract against beta-amyloid precursor protein. The experimental extract revealed fifteen compounds in GC-MS analysis and the highest content was 9, 12, 15-octadecatrienoic acid (z,z,z). The extract showed potent antioxidant activity in in-vitro assays. Furthermore, in in-vivo neurological assays, the extract disclosed significant (p < 0.05) neurological activity. The most favorable phytochemicals as neurological agents were selected via ADMET profiling, and molecular docking was studied with beta-amyloid precursor protein. In the computer-aided study, 1, 5-diphenyl-2h-1, 2, 4-triazoline-3-thione (Pub Chem CID: 2802516) was more active than other identified compounds with strong binding affinity to beta-amyloid precursor protein. The present in vivo and in silico studies revealed neuropharmacological features of G. tetrandra leaf extract as a natural agent against neurological disorders, especially Alzheimer’s disease.

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Comparative neuropharmacological and Cytotoxic profiles of Alstonia scholaris (L.) and Mimusops elengi (L.) leaves

Cited by 10 publications

References 20 publications

Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice

Terpenoids enriched ethanol extracts of aerial roots of Ceriops decandra (Griff.) and Ceriops tagal (Perr.) promote diuresis in mice

Exploring antioxidative, cytotoxic and neuropharmacological insights into Bixa orellana leaves: Experimental and in silico approaches

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

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