Comparative Nephroprotective Effects of Extracts of Buchholzia coriacea on some Biochemical Parameters in Carbon Tetrachloride-induced Toxicity in Rattus novergicus

Abstract

Buchholzia coriacea (wonderful kola) is a medicinal plant that has been used worldwide as an alternative medication to promote human health. Comparative nephroprotective effects of crude seed powder, aqueous and methanolic extracts of B. coriacea in hepatotoxic rats was investigated for 56 days. The crude powder (BCCP), aqueous extract (BCAE) and methanolic extract (BCME) significantly reduced (p<0.05) the levels of creatinine and uric acid and decreased minimally throughout the treatment periods. Total protein increased significantly (p<0.05). Significant decrease (p<0.05) were observed with 200 mg/kg BCAE and BCCP respectively in urea and BUN levels. Noticeable nephroprotective effects may be attributed to the presence of phytochemicals like flavonoids and tannins which act as antioxidants. This study has demonstrated that B. coriacea crude seed powder, methanolic and aqueous extracts caused no adverse effect on the rat kidney and may be recommended for the management of nephrotoxicity
 Dhaka Univ. J. Pharm. Sci. 17(2): 227-235, 2018 (December)

Response Surface Optimization of Bioactive Compounds Extraction from Buchholzia coriacea Using D-Optimal Design

“…Some of the bioactive compounds identified from the Buchholzia coriacea seed extract include Beta-vinyl acrylic acid, 2 methyl perolidine-2-carboxylic acid, hexadecenoic acid, and so on. These bioactive compounds have been reported to possess various medicinal properties [1,2,6].…”

“…Buchholzia coriacea also known as wonderful kola is a medicinal plant frequently used in traditional medicine across Tropical Africa [1]. Studies have shown that Buchholzia coriacea possesses medicinal properties that can be used as antimicrobial, anthelmintic, anti-trypanosomal, hypoglycaemic, and analgesic [2]. The plant has been widely investigated due to its several medicinal properties [3,4].…”

“…Based on existing literature, there are myriads of studies on the use of various types of solvent to extract the active compounds in Buchholzia coriacea. Besides, the medicinal properties and potentials of these active compounds have been extensively investigated [1,2,9]. However, there is dearth of studies on the optimization of the extraction of the active compounds which is the main focus of this study.…”