Comparative molecular analysis of community-associated and healthcare-associated methicillin-resistant Staphylococcus aureus isolates from children in northern Taiwan

Huang, Yhu Chering; Ho, Cheng‐Maw; Chen, C. J.; Su, Lin; Lin, Tzou–Yien

doi:10.1111/j.1469-0691.2008.02115.x

Cited by 78 publications

(81 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two major clones with multidrug resistance belonging to the ST59 lineage accounted for the increasing incidence of MRSA colonization. The two clones also predominated in the clinical CA-MRSA isolates that have been identified in nearly 60% of CA S. aureus infections in Taiwan (18). These observations clearly revealed an accelerated, island-wide transmission of MRSA in the community.…”

Section: Discussionmentioning

confidence: 60%

“…Pulsed-field gel electrophoresis (PFGE) with SmaI digestion was used in this study to fingerprint the MRSA isolates and was performed according to procedures described by Huang et al (22). The genotypes were designated in alphabetical order, as in the previous studies (17)(18)(19); any new genotype identified was designated consecutively. PFGE patterns with fewer than four band differences from an existing genotype were defined as subtypes of that genotype.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Factors Associated with Nasal Colonization of Methicillin-Resistant Staphylococcus aureus among Healthy Children in Taiwan

et al. 2011

View full text Add to dashboard Cite

Methicillin-resistant Staphylococcus aureus (MRSA) has been identified as a major cause of communityassociated (CA) S. aureus infections in the past decade. The main reservoir in the community for MRSA and the factors contributing to its worldwide spread remain poorly defined. Between July 2005 and June 2008, a total of 6,057 healthy children 2 to 60 months of age were screened for carriage of S. aureus and Streptococcus pneumoniae in Taiwan. The prevalence and epidemiological factors influencing MRSA carriage were determined. MRSA strains were tested for antimicrobial susceptibility and underwent molecular characterization. The overall prevalences of MRSA and S. aureus carriage were 7.8% and 23.2%, respectively. A majority (88%) of MRSA isolates belonged to a common Asian-Pacific CA-MRSA lineage, multilocus sequence type 59, and were resistant to multiple non-beta-lactam antibiotics. The carriage rate of MRSA was higher among subjects 2 to 6 months old (P < 0.0001), residing in northern Taiwan (P ‫؍‬ 0.0003), and enrolled later in the study (P < 0.0001). MRSA colonization was associated with the number of children in the family (adjusted odds ratio [aOR], 1.114; 95% confidence interval [CI], 1.002 to 1.240; P ‫؍‬ 0.0463) and day care attendance (aOR, 1.530; 95% CI, 1.201 to 1.949; P ‫؍‬ 0.0006). Breast feeding (P < 0.0001) and colonization with S. pneumoniae (P ‫؍‬ 0.0170) were protective against MRSA colonization. We concluded that epidemic CA-MRSA strains increasingly colonized Taiwanese children between 2005 and 2008. The carriage rate varied significantly across different demographical features. Crowding was an independent environmental risk factor that might accelerate CA-MRSA transmission in the community.

show abstract

Section: Discussionmentioning

confidence: 60%

Section: Methodsmentioning

confidence: 99%

Factors Associated with Nasal Colonization of Methicillin-Resistant Staphylococcus aureus among Healthy Children in Taiwan

et al. 2011

View full text Add to dashboard Cite

show abstract

“…In Taiwan, the ST59/SCCmecVII (or alternatively assigned as V) clone has been noted as a major CA-MRSA clone [32,259,260]. They are mostly PVL-positive [32,259].…”

Section: Taiwanmentioning

confidence: 99%

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

Yamamoto

Nishiyama

Takano

et al. 2010

Journal of Infection and Chemotherapy

129

167

View full text Add to dashboard Cite

Methicillin-resistant Staphylococcus aureus (MRSA) is able to persist not only in hospitals (with a high level of antimicrobial agent use) but also in the community (with a low level of antimicrobial agent use). The former is called hospital-acquired MRSA (HA-MRSA) and the latter community-acquired MRSA (CA-MRSA). It is believed MRSA clones are generated from S. aureus through insertion of the staphylococcal cassette chromosome mec (SCCmec), and outbreaks occur as they spread. Several worldwide and regional clones have been identified, and their epidemiological, clinical, and genetic characteristics have been described. CA-MRSA is likely able to survive in the community because of suitable SCCmec types (type IV or V), a clone-specific colonization/infection nature, toxin profiles (including Pantone-Valentine leucocidin, PVL), and narrow drug resistance patterns. CA-MRSA infections are generally seen in healthy children or young athletes, with unexpected cases of diseases, and also in elderly inpatients, occasionally surprising clinicians used to HA-MRSA infections. CA-MRSA spreads within families and close-contact groups or even through public transport, demonstrating transmission cores. Re-infection (including multifocal infection) frequently occurs, if the cores are not sought out and properly eradicated. Recently, attention has been given to CA-MRSA (USA300), which originated in the US, and is growing as HA-MRSA and also as a worldwide clone. CA-MRSA infection in influenza season has increasingly been noted as well. MRSA is also found in farm and companion animals, and has occasionally transferred to humans. As such, the epidemiological, clinical, and genetic behavior of CA-MRSA, a growing threat, is focused on in this study.

show abstract

“…The long-term carriage pattern of CA-MRSA in healthy hosts is less commonly reported and may be distinct from currently known patterns, which are mostly derived from observations on MSSA. In Taiwan, MRSA has accounted for Ͼ50% of childhood CA infections since 2005 (8). Carriage of MRSA in the nose was identified in 7.8% and 3.7% of the pediatric and adult populations in Taiwan, respectively (7,9).…”

mentioning

confidence: 99%

Longitudinal Analysis of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Carriage in Healthy Adolescents

et al. 2013

View full text Add to dashboard Cite

bTo determine the long-term carriage patterns, strain relatedness, and incidence of subsequent infections among methicillinresistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) carriers, we screened 154 high school students for nasal carriage of S. aureus on 8 occasions over 11 months. Persistent carriage was defined as a positive culture on >7 occasions. Two consecutive isolates from the same subject comprised a pair, and strain relatedness was determined for each pair by molecular typing.

show abstract

Comparative molecular analysis of community-associated and healthcare-associated methicillin-resistant Staphylococcus aureus isolates from children in northern Taiwan

Cited by 78 publications

References 35 publications

Factors Associated with Nasal Colonization of Methicillin-Resistant Staphylococcus aureus among Healthy Children in Taiwan

Factors Associated with Nasal Colonization of Methicillin-Resistant Staphylococcus aureus among Healthy Children in Taiwan

Community-acquired methicillin-resistant Staphylococcus aureus: community transmission, pathogenesis, and drug resistance

Longitudinal Analysis of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Carriage in Healthy Adolescents

Contact Info

Product

Resources

About