Comparative migration of guinea pig T and B lymphocytes from capillary tubes

Scheper, Rik J.; Maarsseveen, T. C. M. T. Van; Dinther-Janssen, A. C. H. M. Van

doi:10.1016/0008-8749(80)90422-0

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…As in the specific chronic inflammatory reaction virtually all plasma cells present displayed anti-DNP-BSA antibody activity, support was obtained for our working hypothesis: in brief, B cells possess a lower intrinsic locomotor capacity than T cells [17], which, together with their proportionally low numbers in the peripheral blood, largely explains their low numbers in inflammatory reactions. Only if an infiltrated B cell is locally encountered by antigen for which it pos sesses specific receptors it may be retained and further stimulated to division and plasmacellular differentia tion.…”

Section: Discussionsupporting

confidence: 67%

Specific Plasma Cell Accumulation in Antigen-Induced Chronic Inflammation in the Guinea Pig Peritoneal Cavity

Dinther-Janssen

Hofland

Scheper

1986

Int Arch Allergy Immunol

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Specificity of plasmacellular infiltration was studied using a guinea pig peritoneal inflammation model. Acute and chronic inflammations were induced by repeated injections of either of two non-crossreacting antigens (DNP-BSA and PPD). With an enzyme-immunohistochemical sandwich procedure allowing quantitation of DNP-BSA-specific plasma cells, specificity of plasmacellular infiltration could be demonstrated. DNP-BSA-specific antibody-forming cells were found not to enter inflammatory reactions elicited by PPD. Our data support the hypothesis that virtually all plasma cells in a chronic inflammatory exudate release antibodies specific for antigens that are locally available, and that such antigens are likely to play a central role in the perpetuation of chronicity.

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