Comparative microscopic analysis of nail clippings from patients with cutaneous psoriasis and psoriatic arthritis

Fonseca, Gabriela Poglia; Werner, Betina; Seidel, Gabriela Bestani; Staub, Henrique Luiz

doi:10.1590/abd1806-4841.20175056

Cited by 12 publications

(8 citation statements)

References 24 publications

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“…Anatomically, there is strong link between PsA and nail inflammation. Psoriatic changes in nails are a known risk factor for the development of arthritis 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Distal interphalangeal joint extensor tendon enthesopathy in patients with nail psoriasis

Krajewska–Włodarczyk

Owczarczyk‐Saczonek

Placek

et al. 2019

Sci Rep

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The aim of the study was an ultrasound assessment of distal interphalangeal (DIP) joint enthesopathy in patients with nail psoriasis. Altogether, 72 patients with nail psoriasis (41 with psoriasis and 31 with psoriatic arthritis) and 30 people in the control group participated in the study. In total, 1014 nails were examined. The thickness of DIP digital extensor tendons in the groups of patients with psoriasis (Ps) and psoriatic arthritis (PsA) was correlated with the nail bed thickness (r = 0.316, p = 0.027 vs. r = 0.402, p = 0.031, respectively) and with the thickness of the nail matrix in patients with psoriasis (r = 0.421, p = 0.012). The linear regression model showed the tendon thickness in Ps patients to be affected by the nail bed thickness, duration of psoriasis and the thickness of the nail matrix, whereas in PsA patients it was found to be significantly affected by duration of psoriasis and of arthritis, the nail bed thickness, CRP concentration and the swollen joint count. Our findings may indicate the role of the nail-tendon apparatus changes in the PsA development and they emphasise the justifiability of US examinations in patients with psoriasis direct assessment of morphological changes in nails as potential predictors of PsA development.

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“…Anatomically, there is strong link between PsA and nail inflammation. Psoriatic changes in nails are a known risk factor for the development of arthritis 20,21 .…”

Section: Discussionmentioning

confidence: 99%

Distal interphalangeal joint extensor tendon enthesopathy in patients with nail psoriasis

Krajewska–Włodarczyk

Owczarczyk‐Saczonek

Placek

et al. 2019

Sci Rep

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“…We found that onycholysis, oil drop, and splinter hemorrhage, in particular, were significantly more prevalent in PsA patients. Fonseca et al found no statistical difference in NAPSI (Nail Psoriasis Severity Index) values among patients with or without psoriatic arthritis [ 20 ]. Perhaps, the type of nail involvement is more important than the severity of nail changes in terms of correlation with PsA.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is still no clear explanation for this association and some believe that this association is limited only to distal interphalangeal (DIP) joints [ 22 ]. The suggested theories are (a) having a common (and yet unknown) autoantigen in both nail apparatus and synovial membrane, (b) anatomic connection between nail structures and DIP joints, and (c) the common role of trauma (Koebner phenomenon) in both nail and arthropathic psoriasis [ 20 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Nail Involvement in Patients with Psoriatic Arthritis in Northern Iran

Zargari

Leyli

Azimi

2018

Autoimmune Diseases

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Background Psoriatic arthritis (PsA) results in an increased burden of psoriasis and impairs both quality of life and an individual's functional capacity. The relationship between nail involvement and PsA in psoriasis is not fully characterized. Aim To evaluate the frequency and characteristics of nail involvement in psoriatic patients and to assess the relationship with joint involvement. Methods A total of 197 patients with moderate-to-severe psoriasis were consecutively invited to participate in this cross-sectional study. The patients are divided into two groups: those with and those without psoriatic arthritis. Results 69.5% of psoriatic (137 out of 197) patients had nail involvement. The most common nail abnormality was onycholysis, followed by pitting and oil droplet changes. Nail involvement was more common in patients with psoriatic arthritis (82.1% versus 57.8%, p=0.001). Conclusion Nail involvement is commonly associated with PsA. Onycholysis, splinter hemorrhage, and oil drop were significantly more common in the PsA group as opposed to patients with just skin findings. In general, psoriatic patients with arthritis had more severe disease.

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“…[8][9][10][11] Recently, the use of nail clipping microscopy as a diagnostic tool for nail psoriasis has also been studied. [12][13][14][15] Although there are many studies delineating the clinical features of nail psoriasis, very few have described the histopathological features, or tried to correlate the two. In an attempt to bridge this gap, this descriptive cross-sectional study was undertaken to study the histopathological features of nail psoriasis.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the use of nail clipping microscopy as a diagnostic tool for nail psoriasis has also been studied . Although there are many studies delineating the clinical features of nail psoriasis, very few have described the histopathological features, or tried to correlate the two.…”

Section: Introductionmentioning

confidence: 99%