Comparative Metabolism of Lincomycin in the Swine Chicken, and Cat

Hornish, Rex E.; Gosline, Ronald E.; Nappier, John

doi:10.3109/03602538708998305

Cited by 35 publications

(24 citation statements)

References 28 publications

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“…For mycoplasma MIC 90 is below 1 μg/mL and this group is thus sensitive for lincomycin after oral administration to pigs. Hornish et al . (1987) reported that the bioavailability of lincomycin in swine varied between 20% and 50% after administration of a dose of 10 mg/kg body weight, which is of the same magnitude as the result in fed pigs in the present study.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs

Nielsen

Gyrd‐Hansen

1998

Vet Pharm & Therapeutics

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The disposition of spiramycin and lincomycin was measured after intravenous (i.v.) and oral (p.o.) administration to pigs. Twelve healthy pigs (six for each compound) weighing 16-43 kg received a dose of 10 mg/kg intravenously, and 55 mg/kg (spiramycin) or 33 mg/kg (lincomycin) orally in both a fasted and a fed condition in a three-way cross-over design. Spiramycin was detectable in plasma up to 30 h after intravenous and oral administration to both fasted and fed pigs, whereas lincomycin was detected for only 12 h after intravenous administration and up to 15 h after oral administration. The volume of distribution was 5.6 +/- 1.5 and 1.1 +/- 0.2 L/kg body weight for spiramycin and lincomycin, respectively. For both compounds the bioavailability was strongly dependent on the presence of food in the gastrointestinal tract. For spiramycin the bioavailability was determined to be 60% and 24% in fasted and fed pigs, respectively, whereas the corresponding figures for lincomycin were 73% and 41%. The maximum plasma concentration of spiramycin (Cmax) was estimated to be 5 microg/mL in fasted pigs and 1 microg/mL only in fed pigs. It is concluded that an oral dose of 55 mg/kg body weight is not enough to give a therapeutically effective plasma concentration of spiramycin against species of Mycoplasma, Streptococcus, Staphylococcus and Pasteurella multocida. The maximum plasma concentration of lincomycin was estimated to be 8 microg/mL in fasted pigs and 5 microg/mL in fed pigs, but as the minimum inhibitory concentration for lincomycin against Actinobacillus pleuropneumoniae and P. multocida is higher than 32 microg/mL a therapeutically effective plasma concentration could not be obtained following oral administration of the drug. For Mycoplasma the MIC90 is below 1 microg/mL and a therapeutically effective plasma concentration of lincomycin was thus obtained after oral administration to both fed and fasted pigs.

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Section: Discussionmentioning

confidence: 99%

Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs

Nielsen

Gyrd‐Hansen

1998

Vet Pharm & Therapeutics

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“…, 1987). Lincomycin is extensively metabolized in liver into N ‐desmethyl lincomycin, and lincomycin sulfoxide and approximately 40% of the administered dose is excreted in the urine as unchanged lincomycin and N ‐desmethyl lincomycin in pigs (Hornish et al. , 1987).…”

Section: Mean ± Se Of the Pharmacokinetic Parameters Of Lincomycin Almentioning

confidence: 99%

Lack of pharmacokinetic interaction between lincomycin and aspirin in healthy goats

Abo‐EL‐Sooud

Goudah

El‐Aty

2004

Vet Pharm & Therapeutics

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“…Additionally, lincomycin could be detected in lagoon manure over a period of 5 months when applied as an amendment to agricultural land. When livestock manure from CAFOs is used as liquid fertilizer, antibiotics may transport to surface and ground water, as well as soil, and act as a reservoir (Hornish et al, 1987; Kuchta and Cessna, 2009b; Kwon, 2011). Therefore, lincomycin is one of the antibiotics that could easily accumulate in the environment adjacent to CAFOs (Hu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Quantification of lincomycin resistance genes associated with lincomycin residues in waters and soils adjacent to representative swine farms in China

Sun

Liu

et al. 2013

Front. Microbiol.

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Lincomycin is commonly used on swine farms for growth promotion as well as disease treatment and control. Consequently, lincomycin may accumulate in the environment adjacent to the swine farms in many ways, thereby influencing antibiotic resistance in the environment. Levels of lincomycin-resistance genes and lincomycin residues in water and soil samples collected from multiple sites near wastewater discharge areas were investigated in this study. Sixteen lincomycin-resistance and 16S rRNA genes were detected using real-time PCR. Three genes, lnu(F), erm(A), and erm(B), were detected in all water and soil samples except control samples. Lincomycin residues were determined by rapid resolution liquid chromatography-tandem mass spectrometry, with concentrations detected as high as 9.29 ng/mL in water and 0.97 ng/g in soil. A gradual reduction in the levels of lincomycin-resistance genes and lincomycin residues in the waters and soils were detected from multiple sites along the path of wastewater discharging to the surrounding environment from the swine farms. Significant correlations were found between levels of lincomycin-resistance genes in paired water and soil samples (r = 0.885, p = 0.019), and between lincomycin-resistance genes and lincomycin residues (r = 0.975, p < 0.01). This study emphasized the potential risk of dissemination of lincomycin-resistance genes such as lnu(F), erm(A), and erm(B), associated with lincomycin residues in surrounding environments adjacent to swine farms.

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Comparative Metabolism of Lincomycin in the Swine Chicken, and Cat

Cited by 35 publications

References 28 publications

Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs

Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs

Lack of pharmacokinetic interaction between lincomycin and aspirin in healthy goats

Quantification of lincomycin resistance genes associated with lincomycin residues in waters and soils adjacent to representative swine farms in China

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