Comparative Metabolic Profiling in Pulp and Peel of Green and Red Pitayas (Hylocereus polyrhizus and Hylocereus undatus) Reveals Potential Valorization in the Pharmaceutical and Food Industries

Lin, Xiao; Gao, Hongmao; Ding, Zheli; Zhan, Rulin; Zhou, Zhaoxi; Ming, Jianhong

doi:10.1155/2021/6546170

Cited by 16 publications

(11 citation statements)

References 73 publications

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“…Multiple studies on red dragon fruit peel have determined that red dragon fruit peel is rich in phytochemical compounds such as phenolics, flavonoids, alkaloids steroids, triterpenoids, fatty acids, and betacyanin (Joshi and Prabhakar, 2020;Luo et al, 2014;Eldeen et al, 2020;Le, 2022;Som et al, 2019;Lin et al, 2021). This study also found the presence of alkaloids, flavonoids, tannins, and saponin compounds in red dragon fruit peels.…”

Section: Discussionmentioning

confidence: 61%

Analgesic and Antipyretic Effects of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract in White Male Rats

Subakti

Ginting²,

Chiuman³

2022

Trad.Med.J

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Red dragon fruit (Hylocereus polyrhizus) is a tropical fruit that is currently cultivated in all tropical parts of the world. It is popular to consume its fruit flesh, while the peel is often thrown away. This red dragon fruit peel (RDFPE) is known to possess lots of phytochemical compounds with multitudes of usage, amongst them as an analgesic and antipyretic. Therefore, the active compounds of RDFPE play an important role in the natural product. This study aims to observe and analyze the analgetic and antipyretic activity possessed by red dragon fruit peel. This study is an in-vivo experiment on 25 white male rats divided into five groups, in which each group receive Na CMC, acetaminophen, and the other three groups will receive three different doses of RDFPE (500 mg/kg, 750 mg/kg, and 1000 mg/kg), respectively. Acetic acid writhing and tail immersion methods were performed to induce inflammation and Brewer’s yeast injection performed induced pyrexia. In the investigation of the acetic acid writhing test, the intervention was administered before induction, and for the tail immersion test, induction was given before and after the intervention was administered. Meanwhile, in brewer’s yeast-induced pyrexia, the rectal temperature was measured before induction, 24 hours after induction, and each hour for five four after the intervention; intervention was administered 24 hours after induction. This study found that RDFPE at the dose of 750 mg/kg and 1000 mg/kg are effective as an analgesic by reducing the average writhing and delaying the tail retraction of the experiment subject and also effective as an antipyretic by reducing the elevated temperature of the experiment subject (p<0.05). This study concludes that RDFPE possesses analgesic and antipyretic activity, especially at the higher dose. Phytochemical compounds such as alkaloids and flavonoids are most likely responsible for this analgesic and antipyretic activity by inhibiting inflammation activity.

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Section: Discussionmentioning

confidence: 61%

Analgesic and Antipyretic Effects of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract in White Male Rats

Subakti

Ginting²,

Chiuman³

2022

Trad.Med.J

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“…Metabolomic analysis was performed using the MetaboAnalystR (1.0.1) package in R [ 9 , 34 ]. To identify DAMs, we implemented orthogonal partial least squares discriminant analysis (OPLS-DA) using MetaboAnalystR according to the following thresholds: variable importance in projection (VIP) score ≥ 1 and absolute log2 FC ≥ 1.…”

Section: Methodsmentioning

confidence: 99%

Integrated metabolomic and transcriptomic analyses of the parasitic plant Cuscuta japonica Choisy on host and non-host plants

Guo

LiuYan

et al. 2022

BMC Plant Biol

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Background Cuscuta japonica Choisy (Japanese dodder) is a parasitic weed that damages many plants and affects agricultural production. The haustorium of C. japonica plays a key role during parasitism in host plants; in contrast, some non-host plants effectively inhibit its formation. However, the metabolic differences between normal dodder in host plants and dodder inhibition in non-host plants are largely unknown. Here, we utilized an integrative analysis of transcriptomes and metabolomes to compare the differential regulatory mechanisms between C. japonica interacting with the host plant Ficus microcarpa and the non-host plant Mangifera indica. Results After parasitization for 24 h and 72 h, the differentially abundant metabolites between these two treatments were enriched in pathways associated with α-linolenic acid metabolism, linoleic acid metabolism, phenylpropanoid biosynthesis, and pyrimidine metabolism. At the transcriptome level, the flavor biosynthesis pathway was significantly enriched at 24 h, whereas the plant–pathogen interaction, arginine and proline metabolism, and MARK signaling-plant pathways were significantly enriched at 72 h, based on the differentially expressed genes between these two treatments. Subsequent temporal analyses identified multiple genes and metabolites that showed different trends in dodder interactions between the host and non-host plants. In particular, the phenylpropanoid biosynthesis pathway showed significant differential regulation between C. japonica in host and non-host plants. Conclusions These results provide insights into the metabolic mechanisms of dodder–host interactions, which will facilitate future plant protection from C. japonica parasitism.

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“…The metabolic profiling of different dragon fruits has enabled the classification of accessions based on fruit size rather than fruit pulp colour [ 139 ], and also demonstrated that the red peel of Hylocereus polyrhizus contained higher amounts of metabolites compared to the green peels of Hylocereus undatus , signifying the nutritional benefits of dragon fruit peels [ 140 ]. Fruit development stages in dragon fruit exhibited signature metabolites that are stage specific and tissue specific which can serve as biomarkers for quality assessment.…”

Section: Fruit Ripeningmentioning

confidence: 99%

Genomic Approaches for Improvement of Tropical Fruits: Fruit Quality, Shelf Life and Nutrient Content

Mathiazhagan

Chidambara

Laxman

et al. 2021

Genes

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The breeding of tropical fruit trees for improving fruit traits is complicated, due to the long juvenile phase, generation cycle, parthenocarpy, polyploidy, polyembryony, heterozygosity and biotic and abiotic factors, as well as a lack of good genomic resources. Many molecular techniques have recently evolved to assist and hasten conventional breeding efforts. Molecular markers linked to fruit development and fruit quality traits such as fruit shape, size, texture, aroma, peel and pulp colour were identified in tropical fruit crops, facilitating Marker-assisted breeding (MAB). An increase in the availability of genome sequences of tropical fruits further aided in the discovery of SNP variants/Indels, QTLs and genes that can ascertain the genetic determinants of fruit characters. Through multi-omics approaches such as genomics, transcriptomics, metabolomics and proteomics, the identification and quantification of transcripts, including non-coding RNAs, involved in sugar metabolism, fruit development and ripening, shelf life, and the biotic and abiotic stress that impacts fruit quality were made possible. Utilizing genomic assisted breeding methods such as genome wide association (GWAS), genomic selection (GS) and genetic modifications using CRISPR/Cas9 and transgenics has paved the way to studying gene function and developing cultivars with desirable fruit traits by overcoming long breeding cycles. Such comprehensive multi-omics approaches related to fruit characters in tropical fruits and their applications in breeding strategies and crop improvement are reviewed, discussed and presented here.

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Comparative Metabolic Profiling in Pulp and Peel of Green and Red Pitayas (Hylocereus polyrhizus and Hylocereus undatus) Reveals Potential Valorization in the Pharmaceutical and Food Industries

Cited by 16 publications

References 73 publications

Analgesic and Antipyretic Effects of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract in White Male Rats

Analgesic and Antipyretic Effects of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract in White Male Rats

Integrated metabolomic and transcriptomic analyses of the parasitic plant Cuscuta japonica Choisy on host and non-host plants

Genomic Approaches for Improvement of Tropical Fruits: Fruit Quality, Shelf Life and Nutrient Content

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