Comparative Macroscopic Study of Osteochondral Defects Produced in Femurs of Rabbits Repaired With Biopolymer Gel Cane Sugar

Abstract

Objective: To study the surface, coloring, consistency, continuity and healing of osteochondral defects produced in the femoral condyles of rabbits and filled with sugar cane biopolymer gel (SCBG), after 90, 120 and 180 days, and in comparison with a control group. Method: Sixteen adult New Zealand white rabbits aged 6 to 7 months, weighing between 2 and 2.5 kg and without locomotor system abnormalities were studied. In all the animals, a defect was made in the femoral condyles of the right and left knees, measuring 3.2 mm in diameter and 4 mm in depth, using a trephine. The animals were divided into two groups: study group formed by the right knees, in which the medial and lateral condyles received implants of SCBG; and control group formed by the left knees, in which the medial and lateral condyles were allowed to heal naturally. The knees were assessed 90, 120 and 180 days after the operation. After the animals had been sacrificed, the anatomical specimens were resected and placed in Bouin's solution. They were then photographed with a Nikon Coolpix 5400® coupled to a Nikon SM2800® stereoscopic loupe, to analyze the surface, coloring, consistency, continuity and healing. Results: The results were evaluated using the chi-square test. There were no significant differences in the macroscopic assessments of healing between the study and control groups. Conclusion: With regard to the surface, coloring, consistency, continuity and healing of the defects, the macroscopic appearance of the tissue repaired with SCBG was similar to that of the control group.

The biopolymer sugarcane as filling material of critical defects in rats

“…In critical bone defects on calvaria of Wistar rats, SCB gel preparations associated with bone morphogenetic protein (BMP) showed to be a suitable scaffold for the BMP, presumably facilitating the controlled release of BMP during bone repair 11 . Although some studies proposed SCB as a promising material for grafting and other medical procedures, none of those researches aimed bone grafting with granulated SCB to this date [12][13][14][15][16][17] . Therefore, this paper focused on the effects of particulate (granule-shaped) SCB on bone repair relating it to its biocompatibility and bone neoformation.…”

Analysis of Biomechanical Parameters in Colonic Anastomosis

“…The SGP gel and tape are exopolysaccharides, biocompatible, of water-based constitution, and low toxicity 11 . The sugarcane molasses polysaccharide has been used in various areas of experimental surgery 1 , 10 , 13 , 14 , 16 , 17 ,29 . This is the first study investigating the effect of the SGP gel and tape on their roles in the biomechanical alterations of the colon.…”

Bacterial cellulose an effective material in the treatment of chronic venous ulcers of the lower limbs

“…In this scenario, bioengineering gains space by associating the use of biomaterials, cell culture and growth factors in the production of instruments aimed at curing skin lesions [8]. Recently, Bacterial Cellulose (BC), a biomaterial produced from biotechnological synthesis, has gained prominence by achieving promising results when used as a dressing and biological graft [9,10].…”

“…BC is produced from the action of the bacterium Zoogloea SP on the substrate of sugarcane molasses [9], manufactured by POLISA, Biopolymers for Health, a startup hosted by the Federal Rural University of Pernambuco (UFRPE). It is an exopolysaccharide and composed of several monosaccharides, glucose (87.57%), xylose (8.58%), ribose (1.68), mannose (0.82%), arabinose (0.37), galactose (0.13%), raminose (0.01%), fructose (0.01) and glucuronic acid (0.83) [11,12].…”