Comparative Investigation Effects On Nervous And Immune Systems Of Bioactive Water Naftussya Spa Truskavets’ And Stable Water Solution Of Boryslav’S Ozokerite

et al. 2019

J Educ Health Sport

Background. Earlier have been shown that the immune responses to course of drinking of Naftussya bioactive water from Truskavet's spa are ambiguous and individual. However, at Truskavets' spa water monotherapy is a rare exception for specific contingents, whereas the vast majority of patients use a balneotherapy complex: drinking of Naftussya, application of ozokerite and mineral baths. The immune responses to balneotherapeutic complex are also ambiguous which is a separate manifestation of the multivariate effects of balneological agents as well stressors on the body. Therefore, the purpose of this study is to analyze variants of immune responses to balneotherapeutic complex of Truskavets' spa. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The survey was conducted twice, before and after balneotherapy (drinking Naftussya bioactive water three times a day, ozokerite applications, mineral baths every other day for 7-10 days). Immune status evaluated on a set of I and II levels recommended by the WHO. In portion of capillary blood we counted up Leukocytogram and calculated two variants of Adaptation Index as well as two variants of Strain Index by IL Popovych. We calculated also the Entropy of Immunocytogram and Leukocytogram. The condition of Microbiota is evaluated on the results of sowing of feces and urine. Results. Four variants of the immune responses to balneotherapeutic complex have been identified. In 40,9% of patients, initially normal immune status did not change significantly. In 31,8%, the lower boundary level of immunity is completely normalized. In 22,7% moderate immunosuppression is reduced, but not up to normal. However, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. Discriminant analysis was conducted to identify exactly the parameters of the immunity and microbiota, in which the four immune response clusters differ significantly from each other. 24 parameters were characteristic, 12 of them related to the immune parameters of the blood, one of the saliva, 5 of the feces microbiota and 3 related to urinary syndrome as well as 4 parameters are information. The other 25 parameters were outside the discriminatory model. Conclusion.

The diversity of immune reactions to balneotherapy and their accompaniments

Struk

Melnyk

et al. 2019

J Educ Health Sport

Vegetative, endocrine and metabolic accompaniments of individual immune responses to adaptogenic balneotherapy

Melnyk

Struk

et al. 2019

J Educ Health Sport

Background. Earlier in clinical observations four variants of the immune responses to adaptogenic balneotherapy at the Truskavets' spa have been identified. In 40,9% of patients, initially normal immune status did not change significantly; in 31,8%, the lower boundary level of immunity is completely normalized; in 22,7% moderate immunosuppression is reduced, but not up to normal; however, in 4,5% of people, initially normal level of immunity are transformed into moderate immunosuppression. All four variants of immune responses are virtually unmistakably predicted by a set of 20 predictors. The purpose of this study is to analyze vegetative, endocrine and metabolic accompaniments of individual immune responses to balneofactors of Truskavets' spa. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets' spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. The survey was conducted twice, before and after balneotherapy (drinking bioactive water Naftussya three times a day, ozokerite applications, mineral baths every other day for 7-10 days). Immune status evaluated on a set of I and II levels recommended by the WHO. The state of the autonomic nervous system is estimated by HRV ("CardioLab+HRV"). To assess endocrine status we determined plasma levels of principal adaptation Hormones: Cortisol, Testosterone and Triiodothyronine (ELISA). We determined also the plasma and daily urine levels of the electrolytes: calcium, phosphates, sodium, potassium, magnesium and chloride as well as nitrous metabolites creatinine, urea and uric acid. According to the parameters of electrolyte exchange, parathyroid, calcitonin and mineralocorticoid hormonal activities was evaluated. We estimated also plasma lipide spectrum. Results. 13 immunosuppressive and 6 immuneenhancing neuro-endocrine and metabolic parameters identified. Discriminant analysis conducted to identify parameters, in which the four immune response clusters differ significantly from each other. 25 parameters are characteristic, 12 of them related to the HRV, 5 to endocrine, 5 to electrolytes and 3 to nitrous metabolites exchange. Conclusion. 208 Individual immune responses to adaptogenic balneofactors are accompanied by characteristic changes in the parameters of the autonomic nervous and endocrine systems, as well as the exchange of electrolytes, nitrogen metabolites and lipids.

Polivariant change of step-test under the influence of natural adaptogens and their accompaniments

Flyunt

Ponomarenko

et al. 2020

PPS

Background. Typically, the step test is used to assess the physical performance that is determined by the condition of the cardio-respiratory system. The latter, in turn, is associated with the nervous, endocrine and immune systems, which collectively determine the level of adaptation of the body. The purpose of this study is to analyze the effect on the step test of natural adaptogens and associated changes in a number of parameters of cardio-respiratory, autonomic nervous and immune systems and metabolism. Material and methods. The target was 80 children of both sexes, ages 10-17, arriving at the clinical sanatorium "Dzherelo" of Truskavets spa from radionuclide contaminated territories. The main subject of the study was the Popovych's step test. State of autonomous nervous and immune systems was assessed as well as others functional and metabolic tests. Results. The contingent surveyed was retrospectively divided into three qualitatively distinct groups. The largest group (53,7%) was the group of children with initially reduced or normal levels of Popovych's Step Test Index (PSI), in which it increased. However, in 28,8% of children PSI remained stable at different initial levels, and in 17,5% even decreased, without falling below the lower limit of normal. Discriminant analysis was subsequently applied to identify constellations of parameters that change are characteristic of each cluster. The program selected as characteristic changes in 2 parameters of autonomous nervous system, 2 functional, 4 metabolic and 3 immune parameters as well as blood trombocytes level. The correct classification of the positive actotropic effect is 93,0%; neutral 65,2%; negative 64,3%, and total correctness is 80,0%. Conclusion. Balneotherapy causes multivariate changes in Popopvych's step test, which accompanied by characteristic changes in certain parameters of autonomous nervous and immune systems as well as others functional and metabolic tests.