Comparative immunomodulatory effects of jelly royal and 10-H2DA on experimental autoimmune encephalomyelitis

Shahla, Jalili; Haghmorad, Dariush; Bijan, Sedighi Moghadam; Eslami, Majid; Zahra, Amiri; Yousefi, Bahman

doi:10.1016/j.genrep.2021.101217

Cited by 3 publications

(1 citation statement)

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“…10‐H2DA, SA, and 10‐HDAA exhibit anti‐inflammatory actions by controlling many proteins implicated in nuclear factor kappa‐B and MAPK signaling (Chen et al., 2016). Several reports have shown the immunomodulatory effects of 10‐H2DA, including a reduction in the growth of T cells, suppression of the formation of interleukin‐12 by spleen dendritic cells, and shut obstruction of LPS‐ and IFN‐β‐induced nitric oxide generation in macrophages (Chen et al., 2016; Shahla et al., 2021). Long life expectancy and enhanced immunity are inextricably linked.…”

Section: Sa 10‐h2da and 10‐hdaamentioning

confidence: 99%

10‐hydroxy decanoic acid, trans‐10‐hydroxy‐2‐decanoic acid, and sebacic acid: Source, metabolism, and potential health functionalities and nutraceutical applications

Liao,

Alrosan,

Alu'datt

et al. 2024

Journal of Food Science

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The popularity of royal jelly (RJ) as a functional food has attracted attention from various industries, especially nutraceuticals, due to the increasing demand from health enthusiasts. Sebacic acid, 10‐hydroxy decanoic acid, and trans‐10‐hydroxy‐2‐decanoic acid are the primary medium‐chain fatty acids (MCFAs) within RJ responsible for their health benefits. This review aims to consolidate information on these MCFAs’ metabolic relationship and health functionalities in nutraceutical applications. We also investigated the natural characteristics mediated by these MCFAs and their metabolism in organisms. Finally, the production of these MCFAs using conventional (from castor oil) and alternative (from RJ) pathways was also discussed. This review can be a reference for using them as functional ingredients in nutraceutical industries.

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Section: Sa 10‐h2da and 10‐hdaamentioning

confidence: 99%