ComparativeIn VitroCytotoxic Effects of Ornidazole, Metronidazole and Ciprofloxacin againstTrichomonas vaginalisTrophozoites

Abstract

A strain of Trichomonas vaginalis, isolated from a patient complaining of vaginal discharge, was incubated and cultivated to compare the in vitro effects of ornidazole, metronidazole and ciprofloxacin on T. vaginalis trophozoites in terms of minimal inhibition concentrations (MICs) and minimal lethal concentrations (MLCs). MIC levels at 24 hours for ornidazole, metronidazole and ciprofloxacin were 50 mg/mL, 50 mg/mL, and 750 mg/mL. Corresponding MLC levels were the same. In this in vitro study, ornidazole was found to be the most effective drug among 3 drugs tested against T. vaginalis trophozoites in terms of MIC and MLC levels. It is interesting to note that ciprofloxacin, although not as effective as the others, also had some cytotoxic effect on T. vaginalis trophozoites.

In Vitro Effect of 5-Nitroimidazole Drugs against Trichomonas vaginalis Clinical Isolates

“…Ornidazole was the only compound against which no resistance was observed. This supports the finding of others that ornidazole is the superior drug for the treatment of trichomoniasis ( 19 , 20 ). Single-dose treatment with ornidazole resulted in 100% trophozoite eradication after 1 week, compared to 95% eradication for the same dose of tinidazole ( 19 ).…”

In vitro Susceptibility of Trichomonas vaginalis to Metronidazole, Ornidazole and Proton Pump Inhibitors Pantoprazole and Esomeprazole

“…Metronidazol, ucuz, güvenilir ve anaerobik mikroorganizmalara ve protozoonlara karşı çok etkili olmasına rağmen, bazı T.vaginalis suşlarının metronidazole karşı direnç kazandığı 1962'den beri gösterilmiştir 5 . Bugüne kadar metronidazole dirençli yaklaşık 100 farklı T.vaginalis suşu bildirilmiştir 6,7 . Nitroimidazoller azomisin (2-nitroimidazol) kimyasal yapısına sahip bileşikler olup, Streptomyces suşundan elde edilmektedir.…”

Pharmacological profile of preparation Оfor in the aspect of rational antimicrobial therapy for mixed infections

“…По данным исследования, проведенного T. Inceboz и соавторами, было доказано, что орнидазол оказался более эффективным, чем метронидазол, в отношении трофозоитов Trichomonas vaginalis по показателям минимальных ингибирующей и ле тальной концентраций. Авторы продемонстрировали, что при одинаковой концентрации препаратов (50 мкг/мл) сущест венно бoльшая доля трофозоитов утрачивает подвижность или погибает после применения орнидазола [25].…”