Comparative hypocholesterolemic effects of six vegetable oils in cholesterol‐fed rat

Fukushima, Michihiro; Akiba, Shiori; Nakano, Masahiro

doi:10.1007/bf02522928

Cited by 25 publications

(21 citation statements)

References 20 publications

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“…Other studies have revealed that high-fat diets promote hyperlipidemia [10] and hyperglycemia [11], and numerous researchers have examined their effects on muscle and liver physiology as well as endothelial function [12-14]. From this experience, it is generally accepted that high-fat diets can be used to generate a valid rodent model for the analysis of the pathophysiology of dyslipidemia [15-17]. Therefore, in this study, high fat diet-induced dyslipidemia rat model was used to examine the combined effects of allicin and fenofibrate on dietary induced lipoprotein changes and liver damage.…”

Section: Discussionmentioning

confidence: 99%

The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats

Wang

Song

et al. 2010

Lipids Health Dis

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BackgroundIt is designed to investigate the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats with hyperlipidemia.MethodsThe healthy male Wistar rats fed high fat diet were treated with fenofibrate (80 mg/kg per day) alone, allicin (60 mg/kg per day) alone and a lower dasage of combined therapy (allicin 20 mg/kg per day and fenofibrate 30 mg/kg per day) respectively for 8 weeks. The serum levels of cholesterol, triglyceride, nitrogen oxidative, alanine transferase (ALT) and aspartate transferase (AST) were determined. Acetylcholine-induced endothelium-dependent vascular relaxation (EDVR) of aorta rings was tested, and the morphologic changes of liver tissue were observed.ResultsCompared with high fat diet control, fenofibrate alone or the combined therapy increased remarkably the levels of high density lipoprotein respectively (P < 0.05). Both single and combined therapy of fenofibrate and allicin significantly enhanced the levels of NO (P < 0.01 or P < 0.05), but the combined therapy had greatest high EDVR responses (P < 0.01). Furthermore, the reduced levels of ALT and AST were significantly obvious in the combined therapy groups (P < 0.01 or P < 0.05). In addition, the lower dosage of combined therapy significantly ameliorated severe fatty degeneration of liver cells occurred in the high fat diet fed rat although the single fenofibrate treatment showed spotty necrosis of liver cells and bile duct expansion.ConclusionCombination therapy with allicin and fenofibrate can effectively enhance the protective effects on endothelial function and reduce the hepatic damage in rats with hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats

Wang

Song

et al. 2010

Lipids Health Dis

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“…Recent studies showed that linolenic acid derivatives, particularly gammalinolenic acid, were found to be even more potent in reducing blood cholesterol in humans and rats [7]. Those studies revealed that vegetable oil rich in polyunsaturated fatty acids are able to decrease the plasmatic levels of verylow-density lipoprotein (VLDL) and low-density lipoprotein cholesterol (LDL-C) and to increase the plasmatic level of high-density lipoprotein cholesterol (HDL-C) [8,9].…”

Section: Introductionmentioning

confidence: 98%

Comparative study of hypocholesterolemic and hypolipidemic effects of conjugated linolenic acid isomers against induced biochemical perturbations and aberration in erythrocyte membrane fluidity

Saha¹,

Chakraborty

Ghosh³

et al. 2011

Eur J Nutr

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“…This observation may reflect only an in vivo response to the lowering of the substrate pool in liver effected by the inhibition of the biosynthetic activities . These effects were accompanied by significant decreases in plasma cholesterol concentrations (18% to 28%), when compared to the control in normal dietfed rats (Table 3) These data indicated that the decrease in TC and LDL-C concentrations in response to CD intake could be caused by changes of some parameters in cholesterol metabolism including fecal excretions of neutral and acidic steroids (Fukushima et al, 1996). There were significant differences in the fecal steroid excretions between the control and CD-fed groups (Table 5).…”

Section: Fecal Steroid Excretionmentioning

confidence: 76%

The Biological Effects of β-Cyclodextrin on Antithrombotic Activity and Plasma Lipid Metabolism in Rats

2003

Journal of Animal Science and Technology

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The effect of feeding a cyclic oligosaccharide, -cyclodextrin( CD) on plasma cholesterol and triacylglyceride concentrations and on antithrombotic activity were investigated in rats fed a control chow diet, or one either high in cholesterol or in saturated fat. The bleeding time of CD-fed groups was significantly prolonged by 293%, 157% and 218% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The whole blood clotting time was significantly increased by 202%, 168% and 211% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The CD diet caused a marked decrease in plasma total lipid (TL), triacylglyceride (TAG), total cholesterol (TC) and low density lipoproteincholesterol (LDL-C) concentrations. The plasma TL concentration was significantly decreased by 70%, 82% and 87% in normal, high cholesterol and high fat diet fed groups as compared to the control group, respectively(p<0.05). The plasma TAG concentration was significantly decreased by 89%, 43% and 59% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The plasma TC concentration was significantly decreased by 28%, 62% and 36% in normal, high cholesterol and high fat diet fed groups, respectively, as compared to the control group(p<0.05). The LDL-C concentration was significantly decreased by 39%, 54% and 25% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The plasma total bile acids contents of CD group was significantly increased by 66%, 95% and 97% in normal, high cholesterol and high fat diet fed groups as compared to control group, respectively(p<0.05). The hepatic HMG-CoA reductase activity was significantly lowered by 41% in the CD-fed group compared to normal diet fed rats(p<0.05). The fecal steroid excretions of the CD groups was significantly increased by 167% in normal diet fed rats(p<0.05). These results suggest that the CD has a biological active function on antithrombotic activity and is hypolipidemic, hypotriglyceridemic and hypocholesterolimic agents. These are all effects that can help to prevent obesity and coronary heart disease in humans.

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Comparative hypocholesterolemic effects of six vegetable oils in cholesterol‐fed rat

Cited by 25 publications

References 20 publications

The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats

The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats

Comparative study of hypocholesterolemic and hypolipidemic effects of conjugated linolenic acid isomers against induced biochemical perturbations and aberration in erythrocyte membrane fluidity

The Biological Effects of β-Cyclodextrin on Antithrombotic Activity and Plasma Lipid Metabolism in Rats

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