Comparative Hemodynamic Effects of MK-422, a Converting Enzyme Inhibitor, and a Renin Inhibitor in Dogs with Acute Left Ventricular Failure

Sweet, Charles S.; Ludden, C. T.; Frederick, C. M.; Bush, Larry R.; Ribeiro, Lair G.T.

doi:10.1097/00005344-198406060-00012

Cited by 24 publications

(7 citation statements)

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“…The early compounds were peptide inhibitors, such as isovaleryl-His-Pro-Phe-HisSta-Leu-Phe-NH 2 (SCRIP), that contained the amino acid statine (34). SCRIP was as effective as the ACE inhibitor enalaprilat in alleviating acute left ventricular failure (35). Similarly, Neisius et al (36) studied a synthetic peptide renin inhibitor, an antirenin antibody, and enalaprilat in the marmoset.…”

Section: Direct Renin Inhibitionmentioning

confidence: 99%

Direct Renin Inhibition with Aliskiren in Hypertension and Target Organ Damage

Müller

Luft

2006

Clinical Journal of the American Society of Nephrology

120

107

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The Joint National Committee and the World Health Organization are in agreement that hypertension in most patients who are treated is controlled inadequately and that rates of cardiovascular morbidity remain high. Additional pharmacologic treatments could ameliorate this situation. The renin-angiotensin-aldosterone system has been a highly successful pharmacologic target, as the system is strongly implicated in the development of hypertension-related target organ damage. However, compensatory increases in plasma renin levels that lead to adjustments in angiotensin production and conversion present limitations for existing renin-angiotensin-aldosterone system inhibitors. A once-daily, orally effective, small-molecule renin inhibitor, aliskiren, is now available to address angiotensin production directly at its rate-limiting step. Studies in humans attest to an effective BP-lowering effect, a side effect profile no different from AT 1 receptor blockers, and the option of combination therapies. A novel animal model of high human renin hypertension in the rat attest to target organ protection. Because angiotensin receptor blockade, angiotensin-converting enzyme inhibition, calcium channel blockade, and diuretic therapy all lead to sharp increases in plasma renin activity, aliskiren offers a novel circumvention.

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Section: Direct Renin Inhibitionmentioning

confidence: 99%

Direct Renin Inhibition with Aliskiren in Hypertension and Target Organ Damage

Müller

Luft

2006

Clinical Journal of the American Society of Nephrology

120

107

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Section: Effects Of Direct Renin Inhibitors On Cardiac Hemodynamic Pamentioning

confidence: 82%

“…In dogs, rats and sheep with heart failure or myocardial infarction (MI), the experimental DRIs EMD 52296, CP71362 and statine-containing renin inhibitory peptide (SCRIP) decreased hemodynamic parameters such as total peripheral resistance and LV end-diastolic pressure compared with baseline/ control [86][87][88]. Similar changes were observed with the ACE inhibitors enalapril and captopril [86,88]. Likewise, LV hypertrophy and LV mass were significantly reduced in spontaneously hypertensive rats and double transgenic mice following treatment with a rat renin inhibitor or a nonpeptide piperidine renin inhibitor, respectively [70,89].…”

Section: Effects Of Direct Renin Inhibitors On Cardiac Hemodynamic Pamentioning

confidence: 99%

Renal and cardio-protective effects of direct renin inhibition: a systematic literature review

Heerspink

Perkovic

Zeeuw

2009

Journal of Hypertension

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“…According to Cohn et al (15), vasodilators are effective not only in chronic heart failure but also in acute heart failure following myocardial infarc tion. Moreover, it was demonstrated that several ACE inhibitors were effective in ALVF induced in experimental animals by coronary embolization (4)(5)(6). Therefore, us ing a similar animal model of ALVF, we eval uated the action of benazeprilat, a new potent and long acting ACE inhibitor with no direct inotropic effect (7,11,16), on acute heart fail ure.…”

Section: Discussionmentioning

confidence: 99%

“…An acute left ventricular failure (ALVF) in duced by repeated injections of plastic micro spheres into the coronary artery has been used for evaluating the effects of ACE inhibitors on heart failure (5-7). ACE inhibitors were found to produce a significant improvement of hemodynamic parameters, especially the left ventricular end-diastolic pressure (LVEDP) (5,7).…”

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confidence: 99%

Hemodynamic Effects of Benazeprilat in the Anesthetized Dog with Acute Left Ventricular Failure.

et al. 1991

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ABSTRACT-To examine the hemodynamic effects of benazepril, an angiotensin con verting enzyme inhibitor, in left ventricular failure, its active metabolite benazeprilat was administered during acute ischemic left ventricular failure in anesthetized open chest dog induced by repeated injections of plastic microspheres into the left coronary artery. The coronary embolization with microspheres resulted in a moderate and stable left ventricular pump failure characterized by increased left ventricular end diastolic pressure (LVEDP) and decreased cardiac output (CO). Benazeprilat (30 ug/kg) administered intravenously after a stabilization period lowered LVEDP and maintained CO. The total peripheral resistance was reduced with benazeprilat. The oxygen consumption and the coronary blood flow were reduced with benazeprilat be cause of a decrease in wall tension and afterload. These results suggest that benazepri lat (benazepril) has beneficial effects for the treatment of acute left ventricular failure.

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Comparative Hemodynamic Effects of MK-422, a Converting Enzyme Inhibitor, and a Renin Inhibitor in Dogs with Acute Left Ventricular Failure

Cited by 24 publications

References 0 publications

Direct Renin Inhibition with Aliskiren in Hypertension and Target Organ Damage

Direct Renin Inhibition with Aliskiren in Hypertension and Target Organ Damage

Renal and cardio-protective effects of direct renin inhibition: a systematic literature review

Hemodynamic Effects of Benazeprilat in the Anesthetized Dog with Acute Left Ventricular Failure.

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