Hemodynamic Effects of Benazeprilat in the Anesthetized Dog with Acute Left Ventricular Failure.

Abstract

ABSTRACT-To examine the hemodynamic effects of benazepril, an angiotensin con verting enzyme inhibitor, in left ventricular failure, its active metabolite benazeprilat was administered during acute ischemic left ventricular failure in anesthetized open chest dog induced by repeated injections of plastic microspheres into the left coronary artery. The coronary embolization with microspheres resulted in a moderate and stable left ventricular pump failure characterized by increased left ventricular end diastolic pressure (LVEDP) and decreased cardiac output (CO). Benazeprilat (30 ug/kg) administered intravenously after a stabilization period lowered LVEDP and maintained CO. The total peripheral resistance was reduced with benazeprilat. The oxygen consumption and the coronary blood flow were reduced with benazeprilat be cause of a decrease in wall tension and afterload. These results suggest that benazepri lat (benazepril) has beneficial effects for the treatment of acute left ventricular failure.

Efficacy of Monotherapy with Benazepril, an Angiotensin Converting Enzyme Inhibitor, in Dogs with Naturally Acquired Chronic Mitral Insufficiency.

“…Inhibition of ACE decreases arterial and ventricular filling pressures, and peripheral vascular resistance, and increases cardiac output [4,13]. The rationale for using ACE inhibitors in congestive heart failure is the facilitation of ventricular emptying by reducing the peripheral vascular resistance [6].…”

“…The rationale for using ACE inhibitors in congestive heart failure is the facilitation of ventricular emptying by reducing the peripheral vascular resistance [6]. The beneficial effect of BP on myocardial performance may be due to reduction of total peripheral resistance, which causes a decrease in the wall tension of the left ventricle and myocardial oxygen consumption [13,15]. Most dogs used in the present study belonged to mild to moderate classes of NYHA heart failure classification (classes II and III).…”