Comparative genetics of the major histocompatibility complex in humans and nonhuman primates

Heijmans, Corrine M. C.; Groot, Natasja G. de; Bontrop, Ronald E.

doi:10.1111/iji.12490

Cited by 32 publications

(29 citation statements)

References 142 publications

(209 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previous studies, five DQA alleles and six DQB alleles were reported from just one Saguinus oedipus individual [ 40 ] and five DQB alleles in an Aotus nancymaae individual were confirmed [ 20 ]. Thus, the presence of a third set of DQ genes has now been demonstrated in three platyrrhine families despite the continued emphasis of two DQ copies that are orthologous with hominids [ 60 , 61 ]. Understanding whether these additional DQ gene copies are functional or pseudogenes will require more genetics research.…”

Section: Resultsmentioning

confidence: 99%

Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae)

et al. 2021

View full text Add to dashboard Cite

The major histocompatibility complex (MHC) is an important gene complex contributing to adaptive immunity. Studies of platyrrhine MHC have focused on identifying experimental models of immune system function in the equivalent Human Leukocyte Antigen (HLA). These genes have thus been explored primarily in captive platyrrhine individuals from research colonies. However, investigations of standing MHC variation and evolution in wild populations are essential to understanding its role in immunity, sociality and ecology. Capuchins are a promising model group exhibiting the greatest habitat diversity, widest diet breadth and arguably the most social complexity among platyrrhines, together likely resulting in varied immunological challenges. We use high-throughput sequencing to characterize polymorphism in four Class II DR and DQ exons for the first time in seven capuchin species. We find evidence for at least three copies for DQ genes and at least five for DRB, with possible additional unrecovered diversity. Our data also reveal common genotypes that are inherited across our most widely sampled population, Cebus imitator in Sector Santa Rosa, Costa Rica. Notably, phylogenetic analyses reveal that platyrrhine DQA sequences form a monophyletic group to the exclusion of all Catarrhini sequences examined. This result is inconsistent with the trans-species hypothesis for MHC evolution across infraorders in Primates and provides further evidence for the independent origin of current MHC genetic diversity in Platyrrhini. Identical allele sharing across cebid species, and more rarely genera, however, does underscore the complexity of MHC gene evolution and the need for more comprehensive assessments of allelic diversity and genome structure.

show abstract

Section: Resultsmentioning

confidence: 99%

Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae)

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Each animal facility has different environmental stressors/stimuli, where certain containments or facilities are maintained under germ-free conditions. Genetic variations in major histocompatibility complex exist among different NHP species or sub-populations (Viray, Rolfs & Smith, 2001;Heijmans, De Groot & Bontrop, 2020). This would potentially generate species or population-specific immune responses even when exposed to the same antigenic/environmental stimuli.…”

Section: Discussionmentioning

confidence: 99%

Exposure-related, global alterations in innate and adaptive immunity; a consideration for re-use of non-human primates in research

Bates

Duncan

Simmons

et al. 2021

PeerJ

View full text Add to dashboard Cite

Background Non-human primates (NHPs) play an important role in biomedical research, where they are often being re-used in multiple research studies over the course of their life-time. Researchers employ various study-specific screening criteria to reduce potential variables associated with subsequent re-use of NHPs. However, criteria set for NHP re-assignments largely neglect the impact of previous exposures on overall biology. Since the immune system is a key determinant of overall biological outcome, an altered biological state could be predicted by monitoring global changes in the immune profile. We postulate that every different exposure or a condition can generate a unique global immune profile in NHPs. Methods Changes in the global immune profile were evaluated in three different groups of rhesus macaques previously enrolled in dengue or malaria vaccine studies over six months after their last exposure. Naïve animals served as the baseline. Fresh blood samples were stained with various immune cell surface markers and analyzed by multi-color flow-cytometry to study immune cell dynamics in the peripheral blood. Serum cytokine profile in the pre-exposed animals were analyzed by mesoscale assay using a customized U-PLEX NHP biomarker panel of 12 cytokines/chemokines. Results Pre-exposed macaques showed altered dynamics in circulating cytokines and certain innate and adaptive immune cell subsets such as monocytes, HLA-DR+NKT cells, B cells and T cells. Some of these changes were transient, while some lasted for more than six months. Each group seemed to develop a global immune profile unique to their particular exposure. Conclusion Our data strongly suggest that re-used NHPs should be evaluated for long-term, overall immunological changes and randomly assigned to new studies to avoid study bias.

show abstract

“…Тем не менее следует учитывать, что выраженность молекулярной мимикрии между белками вируса и хозяина для обезьян может отличаться от проявления данного феномена у человека. Так, разнообразие генов белков MHC у этих животных шире, чем у людей [50]. Совпадение белковых последовательностей вируса и организма хозяина может существенно влиять на выраженность иммунного ответа и степень риска развития осложнений аутоиммунного характера.…”

Section: макак-резусыunclassified

Susceptibility of animal species to experimental SARS-CoV-2 (<i>Coronaviridae: Coronavirinae: Betacoronavirus; Sarbecovirus</i>) infection

Petrova

Ganina

Тарасов

2021

Problems of Virology

View full text Add to dashboard Cite

Due to the new coronavirus infection pandemic, the global scientific community has been forced to change the direction of the most research, focusing on vaccine development as well as the search for new antiviral drugs to treat COVID-19. The choice of experimental models, timeframe and approaches for evaluating drugs and vaccines under development is crucial for the development of effective measures to prevent and control this disease.The purpose of this review was to summarize the relevant data concerning the susceptibility of laboratory animals to SARS-CoV-2. This paper describes the most virus-susceptible animal species that can be used to reproduce coronavirus infection, stressing the main advantages and disadvantages of each of them.According to the latest data, small rodents (Rodentia) and non-human primates (Strepsirrhini) are commonly used in the scientific community to model coronavirus infection. The viral load in the upper and lower parts of the respiratory system, clinical symptoms of infection (weight loss, body temperature and general health status), pathomorphological picture in target organs and the production of antibodies after infection are considered to the main markers of pathology. Despite the vast amount of data, none of the described models of SARS-CoV-2 infection may be considered a gold standard, since they do not reproduce all spectrum of morphological and pathogenetic mechanisms of infection, and do not fully reflect the clinical picture observed in patients in human population.Based on the analyzed literature data, we suppose that Syrian hamster (Mesocricetus auratus) and mice (Muridae) expressing the angiotensin converting enzyme receptor 2 (ACE2) are the most suitable animal species for their use in experiments with SARS-CoV-2 infection. The development of neutralizing antibodies makes it possible to evaluate the efficacy of vaccines, while the course and severity of symptoms infection makes the use of mice and hamsters especially popular for screening pharmacological substances with antiviral mechanism of action, when their administration can prevent or slow the disease progression.

show abstract

Comparative genetics of the major histocompatibility complex in humans and nonhuman primates

Cited by 32 publications

References 142 publications

Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae)

Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae)

Exposure-related, global alterations in innate and adaptive immunity; a consideration for re-use of non-human primates in research

Susceptibility of animal species to experimental SARS-CoV-2 (<i>Coronaviridae: Coronavirinae: Betacoronavirus; Sarbecovirus</i>) infection

Contact Info

Product

Resources

About