Comparative Gastro-Protective Effects of Nigella sativa (Kalojira) and Omeprazole against Aspirin Induced Gastric Ulcer in Albino Rats

Sultana, Nashid; Khan, Ismail; Ahmed, Nasim; Akhter, Shakil; Momtaz, Azmary

doi:10.3329/dmcj.v4i2.29371

Cited by 2 publications

(7 citation statements)

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“…In omeprazole-treated group, the mean length of gastric ulcer was 6.7±2.8 mm and this result was significantly decreased compared with that in the aspirin group. Similar results were found that efficacy of omeprazole in gastro-protection of gastric ulcer enhanced by aspirin in experimental rats [6] .…”

Section: Discussionsupporting

confidence: 86%

“…The gastric gland showed highly sloughing of its cells, degenerated cells with absent nucleus, with marked inflammatory cell infiltration and some hemorrhage. Similar observations were concluded that aspirin is a potent ulcerogenic agent in rats [6,20] .…”

Section: Discussionsupporting

confidence: 82%

“…The rats were fasted for 24 hours, before given the acetylsalicylic acid: the latter was given in a single dose (200 mg/kg body weight acetylsalicylic acid) orally by a gastric tube. Then, rats were sacrificed after four hours [6] .…”

Section: -Aspirin Groupmentioning

confidence: 99%

“…The latter was given in a single dose (200 mg/kg body weight acetylsalicylic acid) orally by a gastric tube. After four hours, the rats had received the omeprazole suspension in a dose of 20 mg/kg omeprazole orally by a gastric tube daily for five days then the rats were sacrificed [6] .…”

Section: -Omeprazole-treated Groupmentioning

confidence: 99%

“…It is prescribed for treatment of peptic ulcer and its complications. But Omeprazole like any drug has some side effects [6] .…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Study Between The Therapeutic Role of Adipose Derived Mesenchymal Stem Cells and Omeprazole in Regeneration of Gastric Ulcer Induced by Aspirin in Albino Rats : Histological and Immunohistochemical Study

Elkerdasy

Mousa

2020

Egyptian Journal of Histology

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Background: Aspirin induced gastric mucosal injury, which leads to gastric ulcer. Adipose Derived Mesenchymal Stem Cells (ADMSC) can be used for treatment of gastric ulcer as they can differentiate into many cell types. Omeprazole is used for treatment of gastric acid-related disorders. The Aim of the Work: Was to compare between the therapeutic role of ADSMC and omeprazole in treatment of gastric ulcer Material and Methods: Forty male albino rats were divided into four equal groups: 1-Control group. 2-Aspirin group in which rats were fasted for 24 hours, then given acetylsalicylic acid (200 mg/kg) once orally for induction of ulcer. 3-ADMSCtreated group in which rats were treated by (3 × 10⁶) ADMSCs/ rat once by intravenous injection four hours after induction of ulcer. 4-Omeprazole-treated group in which rats were treated by omeprazole suspension (20 mg/kg) orally, four hours after induction of ulcer, and for five days. Gastric juice volume and acidity, length of gastric ulcer, and histopathological and immunohistochemical changes of the stomach were all evaluated. Results: Aspirin induced erosion and loss of architecture of gastric mucosal epithelium, ADMSC treatment reduced the length of gastric ulcer, ameliorate histopathological changes and reduced the PCNA-LI also the omeprazole treatment promoted healing of the gastric ulcer induced by aspirin but the therapeutic role of ADMSC was significantly lower in ulcer index and PCNA-LI and better in PAS reaction and histopathological healing of gastric ulcer than the therapeutic role of omeprazole. Conclusion:The therapeutic role of ADMSC was found to be superior to omeprazole in treatment of gastric ulcer.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 82%

Section: -Aspirin Groupmentioning

confidence: 99%

Section: -Omeprazole-treated Groupmentioning

confidence: 99%

“…It is prescribed for treatment of peptic ulcer and its complications. But Omeprazole like any drug has some side effects [6] .…”

Section: Introductionmentioning

confidence: 99%

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A Comparative Study Between The Therapeutic Role of Adipose Derived Mesenchymal Stem Cells and Omeprazole in Regeneration of Gastric Ulcer Induced by Aspirin in Albino Rats : Histological and Immunohistochemical Study

Elkerdasy

Mousa

2020

Egyptian Journal of Histology

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Experimental evaluation of anti-ulcer potential of Nigella sativa oil in gastric ulcers in Albino rats

Khan¹,

Subhani²,

Vaseem³

et al. 2023

J Pre Clin Clin Res.

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Introduction andObjective. Peptic ulcer is a gastrointestinal disease that is characterized by mucosal damage. Nigella sativa (NS) is a medicinal plant increasingly used in practice for treating gastrointestinal diseases. The aim of the study was to evaluate the antiulcer potential of Nigella sativa oil in Albino rats. Materials and method. The study utilized two methods of gastric ulcer induction in Albino rats. The Aspirin-induced gastric ulcer method consisted of 3 groups, with 6 rats in each group, which received pre-treatment once a day orally for 5 days. Group-1 (Control) animals received distilled water. Group-2 (Standard) animals received the standard drug, Ranitidine. Group-3 (Expermintal) animals received the test drug -Nigella sativa oil. The forced swim induced acute gastric ulceration method consisted of 3 groups i.e., control, standard, and test group with 6 rats in each group. After 5 days of respective pre-treatment, the animals were subject to a forced swim test. On day 7, 4 hours after Aspirin ingestion, the animals were sacrificed by stunning. The stomachs of the sacrificed animals was dissected for ulcer scoring. Results. In the Aspirin-induced ulcer method, the percentage protection from ulcer formation was 47.5% in the Nigella sativa group and 52.9% in the standard group. The effect of Nigella sativa oil in comparison to control was statistically significant (p value=0.03). In the forced swim induced acute gastric ulceration method, the percentage protection offered by Nigella sativa oil was 73%, whereas it was 69.6% in the Ranitidine group, and the effect of Nigella sativa oil in comparison to the effect of control was statistically significant (p value=0.03). Conclusions. The study demonstrated that NS oil has significant anti-ulcer potential in rats, which is comparable to the standard drug.

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Comparative Gastro-Protective Effects of Nigella sativa (Kalojira) and Omeprazole against Aspirin Induced Gastric Ulcer in Albino Rats

Cited by 2 publications

References 0 publications

A Comparative Study Between The Therapeutic Role of Adipose Derived Mesenchymal Stem Cells and Omeprazole in Regeneration of Gastric Ulcer Induced by Aspirin in Albino Rats : Histological and Immunohistochemical Study

A Comparative Study Between The Therapeutic Role of Adipose Derived Mesenchymal Stem Cells and Omeprazole in Regeneration of Gastric Ulcer Induced by Aspirin in Albino Rats : Histological and Immunohistochemical Study

Experimental evaluation of anti-ulcer potential of Nigella sativa oil in gastric ulcers in Albino rats

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