Comparative Experimental Study of the Serum Prostate Specific Antigen and Prostatic Acid Phosphatase in Serially Transplantable Human Prostatic Carcinoma Lines in Nude Mice

Epirubicin combined with estramustine phosphate in hormone-resistant prostate cancer: a phase II study

“…Admittedly only nine patients were evaluable. These clinical data are consistent with in vitro observations: PSA production and secretion are androgen dependent, and androgen deprivation may lead to decrease of PSA production without corresponding cell death (Csapo et al, 1988;Rocca et al, 1991;Gleave et al, 1993). Despite the lack of relationship between biochemical and objective response in our and other studies, a relation between treatment-associated PSA reduction and favourable survival in patients with HRPC has been demonstrated (Kelly et al, 1993;Thibault et al, 1993).…”

Human prostate cancer heterotransplants: a review on this experimental model

“…Therefore, the heterotransplanted tumor, in the first passage, always showed a histopathological pattern typical of human prostate carcinoma. This fidelity has been demonstrated for well-differentiated, moderately differentiated and poorly differentiated carcinomas, as well as metastatic tumors that are moderately to poorly differentiated [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Similar results were obtained with poorly differentiated primary carcinomas when the implantation site was the renal subcapsule [29].…”

Effects of 3 Months' Neoadjuvant Hormonal Treatment with a GnRH Analogue (Triptorelin) prior to Radical Retropubic Prostatectomy on Prostate-Specific Antigen and Tumour Volume in Prostate Cancer

“…Similar results were noted by Morgan et al [10], who found female PSA levels after adjuvant endocrine treat ment in patients with D1 tumours. A difference between patients treated hormonally and untreated patients was also found in patients with bone métastasés despite a sim ilar metastatic burden [11], The only other study where the tumour volume was accurately measured was done by Csapo et al [16], who found that mice under hormonal deprivation had 5 times lower PSA levels compared with controls although their tumour volumes were twice as large as those of the controls. Thus, it seems as if the decreased PSA after endocrine treatment is not predomi nantly an effect of decreased tumour volume.…”