Comparative Evalution of G bone (Hydroxyapatite) and G-Graft (Hydroxyapatite with Collagen) as Bone Graft Material in Mandibular III Molar Extraction Socket

Panday, Vijayendra; Upadhyaya, Vivekananda; Berwal, Vikas; Jain, Kapil; Sah, Nupur; Sarathi, Partha; Swami, Pushp Chander

doi:10.7860/jcdr/2015/12140.5713

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…showed increased bone density at 30 and 60 days interval using an inorganic bovine bone graft. 24 Kaur and Maria 33 and Panday et al.’s 34 studies showed a significant increase of density compared to the control group at first and third month, similar to our timelines of study using G-bone as graft material. But none of these studies used nano-HA nor EnHA; so our study is unique to provide the insights of bone regeneration using EnHA in third molar extraction sockets.…”

Section: Discussionsupporting

confidence: 87%

Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute–A randomized controlled clinical study

et al. 2019

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Background Use of various bone graft substitutes are advised to prevent bone loss, periodontal problems, and enhance bone formation after surgical removal of the mandibular third molar. Choice of graft substitute depends on biological properties and the cost of the material. So, a preliminary study was planned to evaluate and compare the effectiveness of eggshell-derived nano-hydroxyapatite as an emerging graft substitute for the enhancement of bone regeneration. Materials and methods Twelve patients (out of 20 enrolled) were finally assessed for bone healing after surgical removal of bilateral mandibular third molars in a split-mouth randomized controlled clinical study. All of them were assessed and compared at baseline, first, third, and sixth month. Clinically wound healing and probing depth were assessed. Radiographically the changes in density, bone formation characteristics, and bone level were evaluated. The observers were blinded for the surgical procedure and follow-up duration. The study protocol was approved by Institutional Ethics Committee and registered with National clinical trial registry. Results Wound healing was uneventful in all 24 extraction sites of 12 patients. Trabecular bone pattern with increased bone density was observed indicating complete bone healing in the graft group at third month. Probing depth was gradually decreased over a follow-up period and remained within normal limits during the third-month follow-up. These changes in the graft group were significant compared to the control group. The grafting with eggshell-derived nano-hydroxyapatite showed better bone regeneration properties without any infection or undue reactions. Conclusion Eggshell-derived nano-hydroxyapatite showed enhancement of bone regeneration compared to the control group. Grafting maintained bone height and prevented periodontal problem emergence. Eggshell-derived nano-hydroxyapatite is a safe synthetic graft substitute because it is derived from eggshell without any diseases transfer risks, unlike allografts. The process of preparation is environment-friendly. The beneficial effects of eggshell-derived nano-hydroxyapatite may be extrapolated to develop an ideal economic graft substitute.

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Section: Discussionsupporting

confidence: 87%

Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute–A randomized controlled clinical study

et al. 2019

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“…Excellent mechanical property not only provides a mechanical support for bone formation, but also makes the materials conducive for use in clinical applications. Both HAPS and HTPS have Young's moduli similar to that of Bio-Oss Collagen, which has been widely used in clinical practice [ 58 , 59 ]. Although we were unable to attain a Young modulus equivalent to that of the natural bone, the mechanical strength achieved by using these biomaterials is stronger than that obtained by using collagen alone [ 60 ] and is enough for dental applications in which the tensile stress is relatively lower [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose‐Derived Stem Cells

Wang

Zhang

et al. 2016

Stem Cells International

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Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite scaffolds (HTPSs), which have an additional β-tricalcium phosphate, resulted in better proliferation of ADSCs and showed osteogenesis-promoting effects. Therefore, such composite scaffolds, in combination with ADSCs or on their own, would be promising for use in bone regeneration and potential clinical therapy for bone defects.

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“…nHA (G-Bone, nHA) is synthetic hydroxyapatite, derived from the bovine bone, which is available as granules and blocks. [ 11 ] Synthetic apatite demonstrates good biological properties, including biocompatibility, bioactivity, lack of toxicity and a relatively high bioresorbability. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of platelet-rich fibrin, platelet-rich fibrin + 50 wt% nanohydroxyapatite, platelet-rich fibrin + 50 wt% dentin chips on odontoblastic differentiation - An in vitro study-part 2

Kottuppallil

Kavitha

2020

J Conserv Dent

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Aim: The purpose of this study was to investigate the effects of platelet-rich fibrin (PRF) modified with bioactive radiopacifiers–nanohydroxyapatite (nHA) and dentin chips (DC) on odontoblastic differentiation in human dental pulp cells (HDPCs). Subjects and Methods: PRF was modified with 50wt% of nHA (G bone-SHAG31, Surgiwear Company) and 50 wt% of DC. HDPSCs differentiation and mineralization by the groups ([Group A - Control (Dimethyl sulfoxide), Group B - PRF, Group C – PRF + nHA, Group D – PRF + DC]) were assessed. ELISA was done to quantify the interleukin (IL)-6 and IL-8 cytokine expression. The odontoblastic differentiation was determined by the expression of odontogenesis-related genes and the extent of mineralization using alizarin red S staining. Statistical Analysis Used: One-way ANOVA with post hoc Tukey-honestly significant difference tests were applied to assess the significance among various groups. Results: The level of inflammatory cytokines (IL-6 and IL-8) expression by Group D (PRF + 50 wt% DC) was higher compared to Group B (PRF) and Group C (PRF + 50 wt% DC). Group C (PRF + 50 wt% nHA) induced more mineralization nodules compared to other groups. The integrated density value for the DSPP and DMP-1 protein expression by Group C (PRF + 50 wt% nHA) and Group D (PRF + 50 wt% DC) was higher compared to Group B (PRF). Conclusions: The results suggest that the addition of bioactive radiopacifiers into PRF has a synergistic effect on the stimulation of odontoblastic differentiation of HDPCs, hence inducing mineralization.

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Comparative Evalution of G bone (Hydroxyapatite) and G-Graft (Hydroxyapatite with Collagen) as Bone Graft Material in Mandibular III Molar Extraction Socket

Cited by 12 publications

References 9 publications

Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute–A randomized controlled clinical study

Use of eggshell-derived nano-hydroxyapatite as novel bone graft substitute–A randomized controlled clinical study

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose‐Derived Stem Cells

Comparative evaluation of platelet-rich fibrin, platelet-rich fibrin + 50 wt% nanohydroxyapatite, platelet-rich fibrin + 50 wt% dentin chips on odontoblastic differentiation - An in vitro study-part 2

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