Comparative Evaluation of Two Antibiotic Pastes for Root Canal Disinfection

Sharma, Sadhna; Bhushan, Urvashi; Goswami, Mridula; Baveja, C.P.

doi:10.5005/jp-journals-10005-1898

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…TAP consists of metronidazole, ciprofloxacin, and minocycline combination, which has been less preferred now primarily due to its crown discoloration. 17 Therefore, such limitations are overcome by DAP as it not only eradicates endodontic pathogens, it does not discolor the crown. 17 …”

Section: Introductionmentioning

confidence: 99%

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The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

Abbasi,

Saqib,

Maqsood

et al. 2023

SAGE Open Medicine

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Objective: The present research evaluated and compared effectiveness between nitrofurantoin and double antibiotic paste in alleviating post-operative pain in patients suffering from symptomatic irreversible pulpitis. Methods: There were 60 subjects enrolled who were allotted among three groups: Group 1 – Nitrofurantoin, Group 2 – double antibiotic paste, and Group 3 – Control. Succeeding access opening and chemo mechanical preparation, intracanal medicament was placed in the root canals. Using a numerical pain scale, pain scores were measured at the following time intervals: preoperative, 12, 24, 48, and 72 h. One-way ANOVA and post hoc statistical analysis were conducted, with a p-value of ⩽ considered as statistically significant. Results: Preoperatively, most patients experienced moderate to severe pain. The patients in groups 1 and 2 reported considerable reduction in their pain scores ( p ⩽ 0.001) on each time interval. However, patients in group 3 experienced a higher level of pain even at 72 h. No considerable distinction was found among participant’s pain scores of groups 1 and 2 ( p = 0.193). Conclusion: For effective pain-relieving, both nitrofurantoin and double antibiotic paste can be successfully used in patients suffering from symptomatic irreversible pulpitis. However, when calcium hydroxide was used, patients experience high levels of pain.

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Section: Introductionmentioning

confidence: 99%

“… 17 Therefore, such limitations are overcome by DAP as it not only eradicates endodontic pathogens, it does not discolor the crown. 17 …”

Section: Introductionmentioning

confidence: 99%

The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

Abbasi,

Saqib,

Maqsood

et al. 2023

SAGE Open Medicine

View full text Add to dashboard Cite

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The antimicrobial efficacy of graphene oxide, double antibiotic paste, and their combination against Enterococcus faecalis in the root canal treatment

et al. 2023

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Background Inter-appointment medication of the root canals with appropriate intracanal medicaments has been advocated to improve root canal disinfection. Graphene oxide (GO) has shown promising antimicrobial activity against a wide range of microorganisms, besides the capability of carrying antibiotics. The current study aimed to compare the antibacterial activity of double antibiotic paste (DAP) and GO per se and in combination (GO-DAP) against Enterococcus faecalis (E. faecalis). Methods A total of 108 extracted human mandibular premolars were contaminated with three-week-old E. faecalis and subjected to a primary microbial assessment. The samples were categorized into 15 groups concerning the intracanal medicament (DAP, GO, GO-DAP, and control) and contact time (1, 7, and 14 days). Then, the root canals were medicated, incubated, and resubjected to a secondary antimicrobial evaluation. The colony-forming units (CFU) were counted to calculate the antimicrobial efficacy. The data were analyzed via the Kruskal–Wallis test (α = 0.05). Results GO-DAP was the only medicament that completely eradicated E. faecalis in 1 day. The percentage reduction of CFU/ml in the GO-DAP and DAP groups was higher than that in the GO group at all allocated contact times. Furthermore, a significant decrease of the CFU/ml was seen in the GO and DAP groups after 7 and 14 days of being medicated (P < 0.05). Conclusion Since GO-DAP improved root canal disinfection, this novel material can be introduced as a promising intracanal medicament against E. faecalis even in the short run.

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Comparative Evaluation of Two Antibiotic Pastes for Root Canal Disinfection

Cited by 2 publications

References 22 publications

The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

The effectiveness of single antibiotic paste nitrofurantoin V/S double antibiotic paste in alleviation of post-operative pain of patients suffering from symptomatic irreversible pulpitis—A randomized controlled trial

The antimicrobial efficacy of graphene oxide, double antibiotic paste, and their combination against Enterococcus faecalis in the root canal treatment

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