Comparative evaluation of therapeutic efficacy and safety of 40% hydrogen peroxide versus 80% of trichloroacetic acid in genital warts

Kaur, Narvinderjeet; Boparai, Amarbir; Kumar, Sumir; Brar, Balvinder Kaur; Singh, O. N.; Bano, Rubeena

doi:10.5455/njppp.2022.12.02059202202052022

Cited by 3 publications

(6 citation statements)

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“…Similarly, in a trial conducted by Smith et al, patients had a twice-weekly application of 45% H 2 O 2 , and statistically significant target wart clearance was achieved in 37.3% out of 76 patients in eight weeks [11]. A study by Kaur et al, in which 40% H 2 O 2 was applied in three sessions at two weeks intervals, revealed a more than 75% reduction in wart size in 30% of twenty patients with genital warts, similarly to our study [5]. TCA has been a time-tested modality for the treatment of warts.…”

Section: Discussionsupporting

confidence: 89%

“…50% H 2 O 2 stands ahead of 100% TCA and 5-FU, with a 65% significant improvement vs. 55% (100% TCA) and 40% (5-FU). Meanwhile, the 80% TCA group had a 70% improvement when compared to 40% H 2 O 2 ( 63% improvement) according to Kaur et al [5]. 50% H 2 O 2 treated patients (group A) had less discomfort and minimal side effects.…”

Section: Discussionmentioning

confidence: 89%

“…peroxidation causing apoptosis. It has been used as a peeling agent and as a chemical cautery agent [5]. Trichloroacetic acid (TCA) causes cellular protein hydrolysis causing tissue damage owing to its caustic property [6].…”

mentioning

confidence: 99%

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Evaluation of the therapeutic efficacy of topical 50% hydrogen peroxide vs. 100% trichloroacetic acid vs. 5% 5-fluorouracil in the treatment of warts

Salecha,

Annamreddy,

Sridevi

et al. 2023

Our Dermatol Online

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Background: Warts (verruca) are caused by human papilloma virus (HPV), which is known to affect the skin and mucosae. Over two hundred strains of HPV have been identified to date, among which few strains cause cutaneous lesions. Various treatment modalities have been elucidated in treating verruca lesions, yet the best therapeutic option is yet to be determined. Objectives: To evaluate the efficacy and safety of topical 50% hydrogen peroxide (H2O2), 100% trichloroacetic acid (TCA), and 5% 5-fluorouracil (5-FU) as a topical application in the treatment of warts. Methods: This was a prospective, interventional, clinical trial that included sixty patients with warts randomly allotted into three groups. Group A and group B were treated every week with topical 50% H2O2 and 100% TCA, respectively, and group C with 5% 5-FU under tape occlusion twice a day. The treatment was executed for a maximum period of eight weeks. The patients were evaluated with the Physician Wart Assessment (PWA) every two weeks of treatment and at three months after treatment completion. Results: At the end of the eight weeks of treatment, 13 patients (65%) in the H2O2 group, 11 patients (55%) in the TCA group, and 8 patients (40%) in the 5% 5-FU group displayed complete clearance of warts (PWA grade 0). In our study, side effects were significantly higher in the TCA group (70%) and in the 5% 5-FU group (60%), notably lower in the H2O2 group (30%) (p = 0.011). The most frequent side effect was irritation (25%), which was reported in all groups. No relapse was encountered at three months of treatment completion. Conclusion: According to our study, H2O2 and TCA have the advantage of earlier action over 5% 5-FU. However, H2O2 remarkably stands as a safer therapeutic option concerning the clearance of lesions, patient tolerability, and side effects. Key words: Warts, H2O2, TCA, 5%, 5-FU

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 89%

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Evaluation of the therapeutic efficacy of topical 50% hydrogen peroxide vs. 100% trichloroacetic acid vs. 5% 5-fluorouracil in the treatment of warts

Salecha,

Annamreddy,

Sridevi

et al. 2023

Our Dermatol Online

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“…A research by Mahran et al, [15] showed that the number and size of warts may be utilized as a predictive indicator to predict treatment response. Kaur et al, [11] showed that, about 30% of the patients in both the groups reported Grade 4 improvement (> 75% reduction in size), 35% versus 25% patients had Grade 3 improvement, 25% versus 20% patients had Grade 2 improvement, and 0 versus 20% had Grade 1 improvement in hydrogen peroxide group versus TCA group, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…In agreement Kaur et al, [11] sought to assess and contrast the treatment effectiveness and safety of a solution of 40% hydrogen peroxide and a solution of 80% TCA for genital warts. Forty patients of more than 18 years of age with clinically diagnosed genital warts were divided into two groups of 20 each, all the 40 patients completed the study, about 42% of the patients were females and 68% were males.…”

Section: Resultsmentioning

confidence: 99%

Topical hydrogen peroxide solution 40%in the treatment of genital warts

Mohamed

Aboelwafa

Saleh

2023

Preprint

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Background; The visible result of a human papillomavirus (HPV) infection caused by one or more of the roughly 100 known strains is genital warts. The most prevalent STD in the world is HPV, and infections with it are strongly linked to major morbidity and death. Numerous malignancies and lesions of the mucosa and epithelium are caused by HPV. Women under the age of 25 are most typically affected by HPV infections, Aim and objectives; to evaluate the efficacy and safety of topical hydrogen peroxide solution 40% in treatment of genital warts, Subjects and methods; this study was a randomized controlled trial that was conducted on 52 patients attending the Dermatology outpatient clinic at Damietta Faculty of Medicine, Al-Azhar University. The selected subjects were divided into 26 patients treated with topical H2O2 as Hydrogen peroxide group and 26 patients treated with saline as control group. Result; There is statistically significant positive correlation between Size of wart after ttt and number of wart after ttt. There is statistically significant reduction in the number of warts with decrease its number after ttt. However, there is no statistically significant correlation between the size and number of warts after ttt with other clinical variables, Conclusion; One possible course of therapy for genital warts may be hydrogen peroxide solution, particularly the 40% concentration. As a novel topical therapy for genital warts, it is very efficient, secure, affordable, and simple to apply,

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Is there any difference in hearing function between surgical and natural menopause?

2022

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Comparative evaluation of therapeutic efficacy and safety of 40% hydrogen peroxide versus 80% of trichloroacetic acid in genital warts

Cited by 3 publications

References 0 publications

Evaluation of the therapeutic efficacy of topical 50% hydrogen peroxide vs. 100% trichloroacetic acid vs. 5% 5-fluorouracil in the treatment of warts

Evaluation of the therapeutic efficacy of topical 50% hydrogen peroxide vs. 100% trichloroacetic acid vs. 5% 5-fluorouracil in the treatment of warts

Topical hydrogen peroxide solution 40%in the treatment of genital warts

Is there any difference in hearing function between surgical and natural menopause?

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