Comparative evaluation of the physicochemical properties of nano-hydroxyapatite/collagen and natural bone ceramic/collagen scaffolds and their osteogenesis-promoting effect on MC3T3-E1 cells

Lei, Xiongxin; Gao, Jianping; Xing, Fangyu; Yang, Zhang; Ma, Ye; Zhang, Guifeng

doi:10.1093/rb/rbz026

Cited by 34 publications

(26 citation statements)

References 59 publications

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“…In addition, the nano-sized particles have an affinity and can induce deposition on irregular spaces (22) . This was also confirmed by researches as Lei X et al (23) who reported that Nano-hydroxyapatite is the most similar compound to the dental tissue having characteristics such as biological compatibility, remineralization potential, antimicrobial growth and nanoparticles size.…”

Section: Discussionsupporting

confidence: 65%

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

Wakwak

Elkady

Basha

2021

Egyptian Dental Journal

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This study was designed to evaluate the effect of four remineralizing agents on surface topography of dentin.Materials and methods: 75 Teeth were divided according to the remineralizing agents into five treatment groups (Control C, CPP-ACP A, NovaMin V, n-HA N & NaF F) 15 teeth each. Time of pH cycling periods were divided to (one week (W1), two weeks (W2) and five weeks (W5)Results: Regarding all of pH cycle periods (W1, W2&W5); there was statistically significant difference between mean dentinal tubules diameter values of the control group on one hand and each of A, V, N and F groups on the other hand. However, there was no statistically significance difference between all those remineralizing agents. The N groups showed the lowest mean value of dentinal tubules diameter while the F groups showed the highest mean value of dentinal tubules diameter.Conclusions: Surface topography of dentin is positively affected by the application of remineralizing agents. Increasing the application rate (pH cycling periods) of the remineralizing agents significantly affect the surface topography of dentin.

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Section: Discussionsupporting

confidence: 65%

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

Wakwak

Elkady

Basha

2021

Egyptian Dental Journal

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“…Previous studies have shown that heparinized β-tricalcium phosphate (β-TCP) supports the adhesion and proliferation of rat MSC and is expected to differentiate into osteoblast lineage compared with β-TCP and control [21] . In another study, natural bone ceramics/type I collagen could promote the expression of early osteogenic genes, while nano-hydroxyapatite (nHA)/COl could up-regulate the expression of late osteogenic genes [22] . Liu Through cell-level research, LGR6 is highly expressed in osteoblast progenitor cells and enhances the Wnt signalling pathway by enhancing the stability of β-Catenin to promote osteogenesis [23] .…”

Section: Discussionmentioning

confidence: 99%

Systematic Analysis of Plasma Exosome MiRNA in Patients with Postmenopausal Osteoporosis

Zhu

Cao

et al. 2021

Preprint

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Background: More and more studies have shown that exosomes are involved in many aspects of bone metabolism. As the content of exosomes, miRNA plays an important role in the early diagnosis, treatment and prognosis evaluation of osteoporosis.Objective: To determine the potential molecular markers of osteoporosis by analyzing the differences of plasma exosome miRNA expression between postmenopausal women with osteoporosis and healthy controls.Methods: Serum samples of postmenopausal osteoporosis (PMOP) patients over 65 years old (n = 12) and healthy controls (n = 12) were collected. The exosomes were separated by molecular size exclusion chromatography(SEC).The differentially expressed miRNAs were analyzed by cluster analysis. The target genes of miRNAs were predicted and annotated by relevant software.The target genes were classified by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The appropriate biomarkers were screened out.Results: The miRNA spectrum of the patients was significantly different from that of the control group. Validation studies showed that 14 up-regulated miRNAs had a high probability of prediction, which could distinguish osteoporosis patients from healthy controls. Thirty-one genes were predicted to be targets for these miRNAs. GO enrichment analysis showed that miRNAs were mainly concentrated in protein binding, carbohydrate-binding, chromatin binding and protein kinase binding. KEGG enrichment analysis showed that miRNAs were mainly concentrated in the p53 signalling pathway, mineral absorption, glycerin metabolism, insulin secretion, glycosaminoglycan biosynthesis heparin sulfate /heparin pathway. This study identified a large number of differentially expressed miRNAs in plasma samples from postmenopausal women with osteoporosis. It may help to obtain new diagnosis and treatment strategies for PMOP.Conclusion: Our study identified the characteristics of plasma miRNAs in patients with osteoporosis and identified 14 candidate miRNAs, which may be useful biomarkers of osteoporosis. We speculate that these differentially expressed miRNAs may play a key role in the process of bone marrow mesenchymal stem cells osteogenic metabolism and transformation.

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“…This is a natural piezoelectric material with a piezoelectric coefficient in the range from 0.2 to 2.0 pC/N [260]. Research has been reported on the application of collagen scaffolds in bone healing [261][262][263][264]. Furthermore, collagen-calcium phosphate composites have been reported for cartilage tissue engineering [265].…”

Section: Collagenmentioning

confidence: 99%

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

2020

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Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities, which still lacks an effective treatment. Tissue engineering in the post-injury brain represents a promising option for cellular replacement and rescue, providing a cell scaffold for either transplanted or resident cells. Tissue engineering relies on scaffolds for supporting cell differentiation and growth with recent emphasis on stimuli responsive scaffolds, sometimes called smart scaffolds. One of the representatives of this material group is piezoelectric scaffolds, being able to generate electrical charges under mechanical stimulation, which creates a real prospect for using such scaffolds in non-invasive therapy of neural tissue. This paper summarizes the recent knowledge on piezoelectric materials used for tissue engineering, especially neural tissue engineering. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges, and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and serves as a starting point for novel research pathways in the most relevant and challenging open questions.

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Comparative evaluation of the physicochemical properties of nano-hydroxyapatite/collagen and natural bone ceramic/collagen scaffolds and their osteogenesis-promoting effect on MC3T3-E1 cells

Cited by 34 publications

References 59 publications

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

Systematic Analysis of Plasma Exosome MiRNA in Patients with Postmenopausal Osteoporosis

Piezoelectric Scaffolds as Smart Materials for Neural Tissue Engineering

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