Comparative evaluation of the hypolipidemic effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in high fat-fed mice

Antihyperlipidemic effects of hydroxyethyl methylcellulose with varying viscosity in mice fed with high fat diet

“…A study conducted by Ban et al (2011) provided the first evidence of the hypolipidemic action of HEMC. It was suggested that the lipidaltering effect of HEMC might be likely associated with its viscosity, similar to that of HPMC and other soluble fibers.…”

“…It was reported to reduce body weight and normalized metabolic abnormalities in obese mice (Hung, Anderson, Albers, Langhorst, & Young, 2011) and lower serum cholesterol level in human subjects (Maki, Carson, Miller, et al, 2009;Reppas, Swidan, Tobey, Turowski, & Dressman, 2009). Recently, HEMC was found to have a hypolipidemic action similar to HPMC (Ban, Rico, Um, & Kang, 2011). The study provided the first evidence that HEMC might also be useful as a functional biomaterial against high fat-induced hyperlipidemia.…”

Systematic review of the mechanisms and evidence behind the hypocholesterolaemic effects of HPMC, pectin and chitosan in animal trials

“…Conversely, HDL-C is considered 'good' cholesterol that protects against cardiovascular diseases (Ban, Rico, Um, & Kang, 2012;Bokura & Kobayashi, 2003;Gunness & Gidley, 2010;Rader & Hovingh, 2014;Yao & Chiang, 2002), and helps scavenge LDL-C from the arteries and carry it back to the liver, where it is broken down (Ban et al, 2012;Hossain et al, 2007;Zong et al, 2012).…”

Antihyperglycemic and Antioxidative Effects of Hydroxyethyl Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose (HPMC) in Mice Fed with a High Fat Diet

“…Our recent investigation on HPMC and HEMC revealed that both of these dietary fibers were similarly effective in suppressing high fat-induced hyperlipidemia in mice [12]. Since HPMC has been previously reported to have an antihyperglycemic effect, it may be possible that HEMC also exhibits the same property.…”