Comparative evaluation of the effects of some flavonoids on alteration of the stomach wall in reserpinized or immobilized mice

Flavonoids with Gastroprotective Activity

“…Of the flavonoids found in this study, forty-two were reportedly inactive; however, this inactivity could vary widely according to the experimental model, animal, route of administration and the dose. For example, flavonols like kaempferol, robinin and dactailin showed no gastroprotective effect in experimental models of reserpine [ 35 , 36 ] and restraint stress-induced ulcers in mouse [ 35 ], but kaempferol at doses of 50 and 100 mg/kg showed gastroprotective activity, and when the dose was increased to 250 mg/kg, it showed no activity [ 37 ]. Similar results were found for nobeletin, a flavone, where doses of 8 and 25 mg/kg protect the gastric mucosa of the rats from injuries induced by ethanol and HCl/ethanol, respectively, but it was only weakly active at a dose of 50 mg/kg in model of aspirin-induced ulcers [ 38 ].…”

In vitro antioxidant properties of rutin

“…In addition, hypolipidaemic, cytoprotective (Casa, Villegas, Alarco´n de la Lastra, Motilva, & Martı´n Calero, 2000), antispasmodic and anticarcinogenic (Webster, Gawde, & Bhattacharya, 1996) activities have also been reported. It has also been found to prevent gastric mucosal ulceration in animal models including restraint stress (Barnaulow, Machineva, & Kamissarenko, 1983). Rutin is a kind of flavonoid glycoside known as Vitamin P and has antiplatelet, antiviral and antihypertensive properties, as well as strengthing the capillaries of blood vessels, which are the results of its high radical scavenging activity and antioxidant capacity (Guo, Wei, & Liu, 2007).…”

FLAVONOIDS AND ANTI-OXIDANT ACTIVITY MEDIATED GASTROPROTECTIVE ACTION OF LEATHERY MURDAH, TERMINALIA CORIACEA (ROXB.) WIGHT & ARN. LEAF METHANOLIC EXTRACT IN RATS

“…Luteolin-7-O-glucoside (Cynaroside) at 47.4 mg/kg and Myricetin at a dose of 0.05 mL/g were found to be active anti-ulcer compounds in mice and rats on screening with reserpine induced gastric ulcers model (4,6,53) . Rutin prevents gastric mucosal ulceration in wide-range of invivo models like absolute ethanol, acidified-ethanol, and reserpine induced gastric ulcers (3,12,22) . The cytoprotective effect is mediated by dose dependent inhibition of mucosal platelet-activating factor (PAF) and anti-oxidant mechanism (22) .…”

“…The beneficial effects of Rutin do not involve effects on endogenous prostaglandins and non-protein sulfhydryls (12) . Quercetin is one of the most studied flavonoids that protects gastrointestinal mucosa from acute lesions induced by various methods like absolute ethanol (23,42,54) , acidified-ethanol (22) , aspirin (54) , indomethacin, pyloric ligation (43) , reserpine (3)(4)(5)(6) and restraint stress (22) induced gastric ulcers. Test-I (TCLME 125 mg/kg); (D) Test-II (TCLME 250 mg/kg) and (E) Test-III (TCLME 500 mg/kg).…”