Comparative evaluation of the antioxidant capacity of smoke flavouring phenols by crocin bleaching inhibition, DPPH radical scavenging and oxidation potential

Bortolomeazzi, Renzo; Sebastianutto, Nerina; Toniolo, Rosanna; Pizzariello, Andrea

doi:10.1016/j.foodchem.2005.11.039

Cited by 160 publications

(112 citation statements)

References 52 publications

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“…Is not commonly isolated from the leaves, and is isolated from Mikania (Sharp et al, 2001) for the fi rst time here. Little research has been conducted in order to verify its bioactivity, and only weak antioxidant activity has previously been found (Bortolomeazzi et al, 2007).…”

Section: Resultsmentioning

confidence: 99%

Isolation of syringaldehyde from Mikania laevigata medicinal extract and its influence on the fatty acid profile of mice

Pedroso¹,

Santos²,

Steil³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Extrato medicinal de Mikania laevigata: infl uência no perfi l de ácidos graxos em camundongos e isolamento de siringaldeído por CLAE semipreparativa". O gênero Mikania é popularmente conhecido como "guaco" e é utilizado para tratar febre, reumatismo, resfriados e afecções respiratórias. Em trabalho prévio demonstramos sinergismo entre os componentes do extrato de M. laevigata para produzir os efeitos farmacológicos esperados, incluindo a cumarina e seu precursor ácido o-cumárico como marcadores. Muitas espécies de Mikania são produtoras de diterpenos ent-caurenos que apresentam atividade antispasmódica e relaxante da musculatura lisa. Buscando a padronização do extrato medicinal de guaco (preparado segundo a farmacopéia brasileira 1ª edição), este trabalho visou determinar a presença de ácido caurenóico através de CLAE-DAD e isolou siringaldeído através de CLAE semipreparativa, sendo que o primeiro não foi encontrado no extrato e o siringaldeído é um dos seus componentes majoritários. Camundongos isogênicos Balb-C portadores de pneumonite alérgica foram tratados com este extrato, e amostras de pulmão e fígado foram analisadas por CG-DIC quanto ao seu conteúdo de ácidos graxos. A quantidade de ácido araquidônico (ARA) e de ácido docosahexaenóico (DHA) encontrada demonstrou que a composição é distinta em ambos tecidos, e apenas a concentração de DHA hepático foi alterado em função do tratamento, o qual não foi encontrado no pulmão. Não foi detectada diferença signifi cativa na produção de ARA. Tanto o extrato aquoso, quanto a cumarina e o ácido o-cumárico, estimularam a síntese de DHA no fígado (p < 0.05). Unitermos:Mikania laevigata, Asteraceae, ácido caurenóico, siringaldeído, ácido araquidônico, ácido docosahexaenóico. ABSTRACT:The Mikania genus is widely known as "guaco" and is used to treat fever, rheumatism, fl u and respiratory diseases. Our previous work evidenced the synergism among M. laevigata extract components to produce desirable effects, and included the coumarin precursor, o-coumaric acid as marker. Many Mikania species are producers of ent-kaurene diterpenes which presented antiespasmodic and relaxant activities on smooth muscle. Seeking to standardize the guaco extract, which is registered in the Brazilian Pharmacopoea, this paper deals with the determination of kaurenoic acid through LC-PDA and the isolation through LC of syringaldehyde. Kaurenoic acid was not found in the extract, and syringaldehyde is one of the major compounds of pharmacopoeal extract, together with coumarin and o-coumaric acid. Samples from the lung and liver of Balb-C isogenic allergic pneumonitis bearing mice, treated with the same extract, were analyzed through GC-FID, and the fatty acid content was determined and analyzed. The results obtained by measuring the arachidonic acid (ARA) and docosahexaenoic acid (DHA) in the liver and lung of treated animals demonstrated that the fatty acid composition is distinct in both tissues, and that in the liver, only the DHA was altered as a result of the treatments. DHA is ...

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Section: Resultsmentioning

confidence: 99%

Isolation of syringaldehyde from Mikania laevigata medicinal extract and its influence on the fatty acid profile of mice

Pedroso¹,

Santos²,

Steil³

et al. 2008

Rev. bras. farmacogn.

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“…As the potential is scanned, the analytical peaks (signals) present on the intensity -potential dependence are the result of the antioxidant molecules' oxidative depletion at the electrode as the specific values of the formal potentials are attained [45]. Especially in recent decades, the oxidation potentials determined by cyclic voltammetry (CV), enable a comparative investigation of the antioxidant potency of phenolics like benzoic acids, hydroxycinnamic acids, and flavonoids, with distinction between substrate types [45][46][47][48][49]. Low oxidation potentials values reflect the propensity of a given molecule for electron donation and thus, for exhibiting significant antioxidant (antiradical) activity.…”

Section: Cyclic Voltammetrymentioning

confidence: 99%

“…Even though, cyclic voltammetry enabled with good results, the analysis of phenolic standards [46], of antioxidants found in wine [52], plant extracts [53][54][55] and biological fluids [48,[56][57][58][59][60]. Cyclic voltammetry also proved reliable with respect to the determination of total antioxidant capacity of plasma, other body fluids and animal tissue homogenates, imparted mainly by the contribution of low molecular weight antioxidants [49,[58][59][60][61][62].…”

Section: Cyclic Voltammetrymentioning

confidence: 99%

Electrochemical Methods for Total Antioxidant Capacity and its Main Contributors Determination: A review

2015

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Abstract:Backround: The present review focuses on electrochemical methods for antioxidant capacity and its main contributors assessment. The main reactive oxygen species, responsible for low density lipoprotein oxidation, and their reactivity are reminded. The role of antioxidants in counteracting the factors leading to oxidative stress-related degenerative diseases occurence, is then discussed. Antioxidants can scavenge free radicals, can chelate pro-oxidative metal ions, or quench singlet oxygen. When endogenous factors (uric acid, bilirubin, albumin, metallothioneins, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-

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“…Anti-inflammatory and antioxidant properties have been described for dihydrocoumarin, reported to be one of the major compounds in hydroalcoholic extracts. Syringaldehyde has been shown to have a moderate antioxidant activity (Bortolomeazzi et al, 2007) and a dose-dependent inhibition of cyclooxygenase-2 (COX-2) activity (IC 50 = 3.5 μg/mL), thereby contributing to the anti-inflammatory properties of guaco extracts (Farah & Samuelsson, 1992;Stanikunaite et al, 2009). Kaurenoic acid (ent-kaur-16-en-19-oic acid) has lately been of considerable interest relating to the pharmacological activities of guaco species.…”

Section: Mikania Glomerata and M Laevigata: Clinical And Toxicologicmentioning

confidence: 99%

Mikania glomerata and M. laevigata: Clinical and Toxicological Advances

Gasparetto¹,

Pontarolo²,

Francisco³

et al. 2012

Toxicity and Drug Testing

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Comparative evaluation of the antioxidant capacity of smoke flavouring phenols by crocin bleaching inhibition, DPPH radical scavenging and oxidation potential

Cited by 160 publications

References 52 publications

Isolation of syringaldehyde from Mikania laevigata medicinal extract and its influence on the fatty acid profile of mice

Isolation of syringaldehyde from Mikania laevigata medicinal extract and its influence on the fatty acid profile of mice

Electrochemical Methods for Total Antioxidant Capacity and its Main Contributors Determination: A review

Mikania glomerata and M. laevigata: Clinical and Toxicological Advances

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