Comparative evaluation of the anti-inflammatory and antinociceptive activity of Turkish Eryngium species

Küpeli, Esra; Kartal, Murat; Aslan, Sinem; Yeşilada, Erdem

doi:10.1016/j.jep.2006.02.005

Cited by 102 publications

(91 citation statements)

References 16 publications

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“…Antinociceptive and anti-inflammatory [31], human erythrocyte and leukocyte protective [32], antispasmodic [33], antimicrobial [34] and antioxidant activities [30,35,36] of different Achillea species growing in Turkey were previously reported. A. latiloba extracts in acetone, ethyl acetate, ethanol, methanol and dimethyl sulfoxide (DMSO) affected bacteria and fungal growth because they probably contain tannins, essential oils, flavonoids and organic acids or other similar substances.…”

Section: Resultsmentioning

confidence: 92%

Screening of various solvents and extracts of Achillea latiloba Ledeb. ex Nordm for antibacterial and antifungal activities

Ertürk

2014

Herba Polonica

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S u m m a r yIn this study the antibacterial and antifungal activities of extracted Achillea latiloba Ledeb. ex Nordm (Asteraceae) samples in acetone, ethyl acetate, ethanol, methanol and dimethyl sulfoxide (DMSO) from Trabzon Province (Turkey) were investigated. Antimicrobial activity of A. latiloba varied depending on the extract of samples, dosage of extracts, and the extraction solvents for all test microorganisms. Staphylococcus aureus, Streptococcus salivarius, Klebsiella pneumoniae, Escherichia coli, Salmonella enteritidis, Streptococcus pneumoniae, Bacillus cereus, Listeria monocytogenes, Streptococcus mutans, Pseudomonas aeruginosa, Bacillus licheniformis, Micrococcus luteus, Bacillus subtillis, Proteus vulgaris andCandida albicans were studied with use of disc diffusion and agar dilution method. The results indicated that each of the crude extracts of Achillea latiloba exhibited a more or less pronounced antibacterial and antifungal potency both in Gram-positive and Gram-negative bacteria and fungi. While in the Gram-negative group, the most sensitive microorganism to Achillea latiloba were S. enteritidis and Streptococcus mutans which is Gram-positive. In the Gram-positive group, the microorganisms most sensitive to Achillea latiloba were Streptococcus mutans and L. monocytogenes. However, the least sensitive microorganism was P. vulgaris. The results presented in this paper suggest that Achillea latiloba possesses additional antimicrobial activities that has an effect against some Gram-negative, Grampositive bacteria and fungi.

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Section: Resultsmentioning

confidence: 92%

Screening of various solvents and extracts of Achillea latiloba Ledeb. ex Nordm for antibacterial and antifungal activities

Ertürk

2014

Herba Polonica

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“…E. billarderi roots have been used for maturation abscess (Ozcelik et al, 2004). Other studies have also indicated that ethanol extract Eryngium species showed anti-inflammatory activity (Kupeli et al, 2006). E. bungei Boiss is locally called Anarigeh.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of plant extracts against oral and skin pathogens

Alipour¹,

Khanmohammadi²

2011

Afr. J. Microbiol. Res.

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The aim of this study is to examine the antibacterial activity of plant extracts. Both broth dilution and disc diffusion methods were used to assess the antibacterial activity of these extracts against skin and oral pathogens. Eryngium caucaseum Trautv, Eryngium bungei Boiss and Adiantum capillus-veneris have shown antibacterial activity against Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus and Streptococcus sanguis. E. caucaseum Trautv showed the highest inhibition zone (> 30 mm) against S. pyogenes. The growth of S. pyogenes was remarkably inhibited by the ethanolic extract of the three plant extracts.

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“…In Turkish folk medicine, various species of the plant are used for a wide range of ailments; particularly, roots are used against various inflammatory disorders, edema, sinusitis, urinary infections or inflammations etc., and snake or scorpion bites or goiter; roots and leaves for infertility and herbs for wound healing as well as food while fresh (Küpeli et al, 2006). Eryngium extracts or isolates have shown in vitro bioactivities such as cytotoxicity aganist various human tumor cell lines, anti-inflammatory, anti-snake, and scorpion venoms, antibacterial, antifungal, antimalarial, antioxidant and antihyperglycemic effects.…”

Section: Introductionmentioning

confidence: 99%

“…The aerial and root parts of Eryngium maritimum L. and Eryngium kotschyi Boiss. were found to possess the most promising antiinflammatory and the antinociceptive activity without including any apparent gastric damage in rats (Küpeli et al, 2006). Aslan-Erdem et al (2011) studied the antinociceptive activity of E. kotschyi root (EKR) extracts and isolated a triterpene saponin related to this activity.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic effects ofEryngium kotschyiandEryngium maritimumon Hep2, HepG2, Vero and U138 MG cell lines

Yurdakok¹,

Baydan²

2013

Pharmaceutical Biology

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Context: Eryngium maritimum L. and the endemic Eryngium kotschyi Boiss. of the Apiaceae family are used for antiinflammatory, antivenom, antinociceptive and diuretic purposes in folk medicine in Turkey.Objective: This study investigated the cytotoxic effects of the plant extracts belonging to Eryngium L. genus on various cell lines. Materials and methods: Cytotoxic activites of the lyophilized aqueous aereal and root parts of the plant extracts on human hepatocellular carcinoma (HepG2), human laryngeal epidermoid carcinoma (Hep2), human glioma (U138-MG) and African green monkey kidney epithelial (Vero) cell lines at 8.33-266.62 mg/ml concentrations were analyzed by lactate dehydrogenase (LDH) leakage and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) cell viability assays. Results: Inhibitory concentration 50 (IC 50 ) values were found 5100 mg/ml in most cases varying around 16.33-125.66 mg/ml. IC 50 values for E. kostchyi and E. maritimum root parts on Hep2 cells (32.86 and 30.25 mg/ml, respectively), E. kotschyi aereal, E. maritimum aereal and root parts on HepG2 cells (31.75, 32.42 and 35.01 mg/ml, respectively) by MTT assay were found to be close to the US National Cancer Institute (NCI) recommendations (IC 50 530 mg/ml) to define the antivity aganist cancer cells. The lowest IC 50 values according to the LDH method were observed in Hep2 cells and the highest in U138-MG cells. Root parts were found to be more toxic than aereal parts for both plants in both methods in general. Discussion and conclusion: Both plant extracts exerted cytotoxic activity aganist Hep2 and HepG2 cells, with low IC 50 values defining their promising anticancer property according to NCI; however, further analysis are needed to confirm their activity.

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Comparative evaluation of the anti-inflammatory and antinociceptive activity of Turkish Eryngium species

Cited by 102 publications

References 16 publications

Screening of various solvents and extracts of Achillea latiloba Ledeb. ex Nordm for antibacterial and antifungal activities

Screening of various solvents and extracts of Achillea latiloba Ledeb. ex Nordm for antibacterial and antifungal activities

Antibacterial activity of plant extracts against oral and skin pathogens

Cytotoxic effects ofEryngium kotschyiandEryngium maritimumon Hep2, HepG2, Vero and U138 MG cell lines

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