Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Mathieu, Laurence; Burgher, François; Blomet, Joël

doi:10.1016/j.jchas.2007.02.001

Cited by 15 publications

(9 citation statements)

References 14 publications

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“…31,32 Hexafluorine is an active decontamination solution. 14,24,33,34 It is not irritating to the eyes and skin and is nonsensitizing and nontoxic. Hexafluorine is water soluble, supplied as a sterile solution, and would be expected to have the same dilutional and mechanical rinsing action as a similar volume of water.…”

Section: Discussionmentioning

confidence: 99%

Seventy Per Cent Hydrofluoric Acid Burns: Delayed Decontamination With Hexafluorine® and Treatment With Calcium Gluconate

Yoshimura¹,

Mathieu²,

Hall

et al. 2011

Journal of Burn Care & Research

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This is a case report of decontamination and treatment of a 70% hydrofluoric acid (HF) dermal splash injury. A worker was splashed with 70% HF, sustaining approximately 10% TBSA first- to third-degree chemical skin burns of the face, trunk, and left thigh and leg. Initial decontamination involved water rinsing, removal of contaminated clothing, more water rinsing, topical application of magnesium oxide, and administration of intravenous narcotics for management of severe pain. After a delay of approximately 3 hours, active skin washing with Hexafluorine®, 5 L, was performed, followed by intravenous, intradermal perilesional, and topical inunction administration of calcium gluconate. Pain relief and a cooling sensation were quite prompt after Hexafluorine® decontamination. Surgical debridement and skin grafting of the more severe burns were required. No significant systemic toxicity developed, although this has occurred in previously reported similar concentrated HF dermal splash exposure cases, some of which resulted in fatality. While burns did develop, the patient was released from the intensive care service after 2 days and, after skin grafting, had a good outcome at 90-day follow-up. Even after a long delay, decontamination with Hexafluorine® appeared to be beneficial in this case.

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Section: Discussionmentioning

confidence: 99%

Seventy Per Cent Hydrofluoric Acid Burns: Delayed Decontamination With Hexafluorine® and Treatment With Calcium Gluconate

Yoshimura¹,

Mathieu²,

Hall

et al. 2011

Journal of Burn Care & Research

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“…The efficacy of traditional water rinsing for skin chemical splashes has been questioned in recent years [155,[200][201][202]. Andrews et al [203] note that in a rat skin injury model with 2 N sodium hydroxide, a 5 % acetic acid solution was superior to water decontamination [203].…”

Section: Efficacy Of Water Rinsing: Evidence or Lack Of Evidencementioning

confidence: 99%

“…Following extensive literature searches, the evidence for the efficacy or limits thereof of water rinsing of chemical skin splashes was reviewed [115,[200][201][202]. Various types of information were retrieved: (1) occupational chemical skin injury information collected by or assembled from governmental or regional sources, (2) burn center/unit data, (3) in vitro and experimental animal data, and (4) case reports, small case series, and epidemiological studies.…”

Section: Efficacy Of Water Rinsing: Evidence or Lack Of Evidencementioning

confidence: 99%

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Damaged Skin

Burgher¹,

Mathieu²,

Blomet

et al. 2014

Chemical Skin Injury

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“…En Europa se han desarrollado productos que por su naturaleza anfótera, logran neutralizar los agentes químicos de forma más rápida que el lavado con agua logrando así evitar la progresión de la quemadura y favoreciendo la recuperación tisular, sin embargo no se cuenta con acceso a éstos en Colombia (4,(14)(15)(16)(17)(18)(19).…”

Section: Introductionunclassified

Evaluación de extractos vegetales para manejo de quemaduras cáusticas: irritación/corrosión dérmica aguda. Bogotá/2018

Céspedes

Ospina

Vargas³

et al. 2018

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Londoño Valero10, Laura del Mar Lozada Cruz10 Licencia creative commons ResumenIntroducción: Aunque las quemaduras cáusticas representan un bajo porcentaje de las quemaduras, dadas las complicaciones que asocian, son un problema de salud pública que exige nuevas opciones terapéuticas como son el uso de productos derivados de plantas, entre ellos, Calendula offinalis, Aloe vera y Cannabis sativa, cuyo uso está condicionado, inicialmente a pruebas como la evaluación de su efecto irritativo/corrosivo agudo en piel. Materiales y métodos:Estudio experimental en animales, aleatorizado. El material vegetal se obtuvo del Jardín Medicinal Jorge Piñeros Corpas; los aceites y extractos de las plantas se obtuvieron por métodos clásicos de extracción; la base de excipientes fue provista por el Laboratorio de Farmacología Vegetal (LABFARVE). Se emplearon 8 Ratas wistar macho alojadas bajo condiciones controladas y parámetros de ética y bienestar animal. La prueba de irritación/corrosión dérmica aguda se hizo siguiendo la norma OECD 404, tras previa anestesia de los animales y siguiendo los criterios de dolor y punto final.Resultados: De Calendula officinalis se obtuvieron dos aceites esenciales y tres extractos; el gel de Aloe vera y un extracto de Cannabis sativa. Ninguno de los extractos generó escara, eritema o edema en los animales, siendo negativa la prueba de irritación/corrosión aguda en piel.Discusión: Los resultados obtenidos desde esta investigación básica en medicina traslacional, brindan evidencia que complementa la información reportada en la literatura acerca del uso tradicional y los estudios in vitro e in vivo de estas plantas para el manejo de diversas enfermedades. La ausencia de efecto irritativo o corrosivo en piel es coherente con el conocimiento del tipo de metabolitos secundarios activos que se han identificado en ellas con actividad antiinflamatoria, antioxidante, antimicrobiana y cicatrizante. Los resultados aseguran su inocuidad química al contemplarlas para investigar su potencial uso terapéutico en lesiones dérmicas, tipo quemaduras cáusticas, garantizando su seguridad . AbstractIntroduction: Considering that caustic burns represent a low percentage of burns, given the complications they could associate, they are a public health problem that requires new therapeutic options such as the use of plant-derived products, including Calendula offinalis, Aloe vera and Cannabis sativa, whose use is conditioned, initially to tests such as the evaluation of its acute irritative / corrosive effect on skin.

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Comparative evaluation of the active eye and skin chemical splash decontamination solutions Diphoterine and Hexafluorine with water and other rinsing solutions: Effects on burn severity and healing

Cited by 15 publications

References 14 publications

Seventy Per Cent Hydrofluoric Acid Burns: Delayed Decontamination With Hexafluorine® and Treatment With Calcium Gluconate

Seventy Per Cent Hydrofluoric Acid Burns: Delayed Decontamination With Hexafluorine® and Treatment With Calcium Gluconate

Damaged Skin

Evaluación de extractos vegetales para manejo de quemaduras cáusticas: irritación/corrosión dérmica aguda. Bogotá/2018

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