Damaged Skin

Burgher, François; Mathieu, Laurence; Blomet, Joël; Gilpin, Sarah; Maibach, Howard I.; Whaby, Aziza; Hall, Alan H.; Rhavar, Maral; Hui, Xiaoying; Jacquemin, Dominique; Cavallini, Maurizio; Yoshimura, Carlos Alberto; Chan, Heidi P.

doi:10.1007/978-3-642-39779-0_4

Cited by 2 publications

(3 citation statements)

References 305 publications

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“…The patients in our current series had the following features: ( a ) definite history of DCP exposure; ( b ) a shared workshop; ( c ) rapid onset of ICD after single DCP exposure; ( d ) clinical manifestations including edematous erythema and vesicles on exposed skin, along with a burning sensation and pruritus; and ( e ) histopathologic manifestations of ICD. 6 Therefore, our series met the diagnostic criteria of DCP-induced acute ICD, 7 which is cutaneous inflammation without the production of specific antibodies. We think that the DCP caused the skin irritation via a mechanism unrelated to its pH of 6.2.…”

Section: Discussionmentioning

confidence: 92%

Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine

Fan

Zhang²,

Zhang

2021

Dermatitis

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Background There are no reported cases of 2,4-dichloro-5-methylpyrimidine (DCP)–induced irritant contact dermatitis (ICD). Objective The aim of the study was to summarize the clinical features, treatment, and protective measures for DCP-induced ICD. Methods We retrospectively reviewed the clinical data from 64 patients with DCP-induced ICD and the protective measures in a DCP manufacturing factory. Results Disease onset occurred 1 to 10 minutes after DCP single exposure in all 64 patients. The contact site developed edematous erythematous skin lesions with clear boundaries. Other symptoms included a burning sensation (n = 48), pruritus (n = 16), headache (n = 4), nausea/vomiting (n = 3), and syncope (n = 1). Ten patients developed pruritic rash over the whole body 1 to 4 days after contacting DCP. Histopathologic examination of the lesions was performed in 8 patients; all 8 showed manifestations of ICD. A patch test with 1% DCP ethanol solution was performed in 7 patients. One patient withdrew because of pruritus and massive erythema over the whole body. Four patients had a strong reaction, and 2 patients had a very strong reaction. All patients were cured. Positive-pressure inflatable protective clothing protected workers from the outside environment to prevent DCP-induced ICD. Conclusions 2,4-Dichloro-5-methylpyrimidine exposure induces acute ICD and a delayed allergic reaction in some patients (15.6%). Positive-pressure inflatable protective clothing prevents DCP-induced ICD.

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Section: Discussionmentioning

confidence: 92%

Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine

Fan

Zhang²,

Zhang

2021

Dermatitis

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“…Chemical burn is an uncommon cause of burn injuries in the paediatric population and accounts for less than 10 % of burns treated in the emergency department [ 8 ].…”

Section: Casementioning

confidence: 99%

“…If the clothing is strongly adherent to the skin after spillage, pulling the clothing off should be avoided and soaking the affected area with tap water is often helpful. Monitoring the pH of the wound, although it is impractical outside a hospital setting, may help to determine the adequacy of the irrigation [ 8 ].…”

Section: Casementioning

confidence: 99%

Paediatric burns secondary to nail adhesives: a case series

et al. 2016

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BackgroundNail adhesives are widely available beauty products that are used in the cosmetic industry and households to attach false nails. Nail adhesive burns are uncommon, and it is crucial that healthcare providers and the public are aware of its potential to cause chemical burn.Case PresentationCase series of accidental burns secondary to cyanoacrylate nail glue treated at the Welsh Centre for Burns and Plastic Surgery (WCBPS) in Swansea, United Kingdom.ConclusionAll of the burns were observed in children and occurred due to accidental spillage. Therefore, it is important for the public to be aware that nail glue is a chemical agent which should be stored safely away from the reaches of young children. The case series highlights the importance of first aid in reducing the severity of chemical burns secondary to the nail adhesives, and its early recognition and treatment are emphasised.

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Damaged Skin

Cited by 2 publications

References 305 publications

Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine

Clinical Manifestations, Treatment, and Prevention of Acute Irritant Contact Dermatitis Caused by 2,4-Dichloro-5-Methylpyrimidine

Paediatric burns secondary to nail adhesives: a case series

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