Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries

Subramanyam, Divya; Gurunathan, Deepa; Gaayathri, R.; Priya, V. Vishnu

doi:10.4103/ejd.ejd_266_17

Cited by 127 publications

(119 citation statements)

References 27 publications

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“…In addition, multivariate linear regression shows that caries severity is the variable associated with salivary oxidative damage. Taken together, our data demonstrate that carious lesion progression reduces salivary oxidative damage [39,40].…”

supporting

confidence: 69%

“…Our results corroborate previously obtained data showing that the TBARS concentration in saliva of children with E-SCC (0.0019 μmol/L/mg of protein) is lower than in saliva of caries-free children (0.0039 μmol/L/mg of protein). However, recent studies [39,40] have reported controversial results: salivary TBARS concentrations in children aged six years and in patients aged 15-19 years with caries lesions (0.26 μmol/L and 0.71 nmol/mL, respectively) are increased as compared to caries-free patients. Methodological differences may account for the discrepancies between our results and literature data.…”

Section: Discussionmentioning

confidence: 97%

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Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Araujo

Nakamune

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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Oxidative stress biomarkers can be found at detectable concentrations in saliva. These salivary biomarkers reflect specific oxidation pathways associated with caries and periodontitis. Our study evaluated the influence of dental caries severity (assessed using the ICCMS™ criteria) on the levels of oxidative stress biomarkers in saliva from children. Unstimulated saliva samples were collected from patients (from one to three years old) in a day care center in Birigui, SP, Brazil, two hours after fasting. Children were divided into four groups (n=30/group), according to caries severity: caries free (group A), early carious lesions (group B), moderate carious lesions (group C), and advanced carious lesions (group D). The following salivary biomarkers were determined: total proteins (TP), measured by the Lowry method; oxidative damage, measured by the TBARS method; total antioxidant capacity (TAC); superoxide dismutase (SOD) enzymatic antioxidant activity; and uric acid (UA) non-enzymatic antioxidant activity. Data were analyzed by ANOVA, followed by the Student-Newman-Keuls test, Pearson and Spearman correlation coefficients, and multivariable linear regression (p<0.05). TP, TAC, SOD enzymatic antioxidant activity, and UA non-enzymatic antioxidant activity increased with caries severity, consequently reducing salivary oxidative damage. It was concluded that higher caries severity increases salivary antioxidant system activity, with consequent reduction in salivary oxidative damage.

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supporting

confidence: 69%

Section: Discussionmentioning

confidence: 97%

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Araujo

Nakamune

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Fluoridated toothpaste should be used which removes dental plaque effectively thereby decreasing the incidence of oral disease (Ramakrishnan and Shukri, 2018;Somasundaram, 2015;Subramanyam et al, 2018). A chewable toothbrush can be used instead of the manual toothbrush for effective removal of dental plaque (Packiri, 2017;Christabel, 2015;Govindaraju, 2017).…”

Section: Resultsmentioning

confidence: 99%

Gingival health status in patients with and without anterior open bite: A case-control study

Kuzhalvaimozhi

Ravindran

Subhashini

2020

ijrps

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Open bite is the absence of vertical overlap of lower incisors by upper incisors when posterior teeth are in occlusion. An anterior open bite can cause periodontal damage which leads to gingivitis and periodontitis. To assess the gingival health status in patients with anterior open bite and also compares with patients without an anterior open bite. Retrospective data collected from 89,000 case records from June 2019 to March 2020. The present study consisted of 76 patients divided into two groups: patients with anterior open bite and patients without an anterior open bite. In both groups, the following parameters were recorded - Oral Hygiene Index - Simplified (OHI-S) and Plaque Index (Silness and Loe). OHI-S index and plaque index was similar in patients with and without an anterior open bite. Mean Plaque Index for case group (patients with anterior open bite) is 0.76, and Mean Plaque Index for control group (patients without the anterior open bite) is 0.78. Mean OHI-S Index for case group (patients with anterior open bite) is 0.51, and Mean OHI-S Index for the control group (patients without the anterior open bite) is 0.53. The difference was not statistically significant (P-value > 0.05). In this study, gingival health status in patients with and without an anterior open bite is low.

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“…When pediatric dental patients do not comply with conventional dental treatment, to provide comprehensive and high quality dental treatment, dental practitioners resort to general anesthesia as an aid to the existing treatment modalities (Somasundaram, 2015;Jeevanandan and Govindaraju, 2018;Subramanyam et al, 2018). Physical/mental disability, developmental delay, and acute or chronic disease are potential reasons for noncompliance during the dental appointment.…”

Section: Introductionmentioning

confidence: 99%

Assessment of factors affecting parent’s preference of general anesthesia for performing pedodontic procedures in a university hospital set up

Jessy

Manjari

2020

ijrps

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Dental practitioners should use their knowledge and skills and be able to identify and effectively treat dental diseases in children. The child’s and family’s response should be taken into account for providing safe and effective treatment for the paediatric patients. The present study aims to analyse the preference of GA by parents for children under 5 years of age. This retrospective study was conducted among the paediatric dental patients under 5 years of age visiting Saveetha Dental College and Hospitals. The data of the 154 patients who were indicated for GA procedure were collected. The collected data was statistically analysed using IBM SPSS Software (20.0). The results proved that the majority (72.08%) of the parents did not accept the GA procedure. Parents of 3 year old children were the most accepting (44.2%) of GA procedure. Among gender,parents of female children show a slightly higher percentage of acceptance (51.2%) when compared to the parents of the male children (48.8%). Most common reason for acceptance was parents of children undergoing full mouth rehabilitation procedures(55.8%). Majority of the parents who accepted the GA procedure were educated (83.7%) which shows that educational qualification plays an important role. Therefore it is important to bring the positive attitude among parents for delivering safe and quality dental treatment.

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Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries

Cited by 127 publications

References 27 publications

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children’s Saliva

Gingival health status in patients with and without anterior open bite: A case-control study

Assessment of factors affecting parent’s preference of general anesthesia for performing pedodontic procedures in a university hospital set up

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