Comparative Evaluation of Quantitative Glomerular Filtration Rate Measured by Isotopic and Nonisotopic Methods

Balachandran, Suppiah; Toguri, Allan G.; T, Petrusick

doi:10.1097/00003072-198104000-00003

Cited by 28 publications

(14 citation statements)

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“…Another method that is accepted for GFR measurement with 99m Tc-DTPA is plasma sampling. In a study by Balachandran et al, 15 a suspicious correlation was identified between 24 h CrCl and GFR measured with 99m Tc-DTPA with multiple plasma sampling, and when inulin clearance was compared with GFR calculated with 99m Tc-DTPA with multiple plasma sampling, this correlation was significant.…”

Section: Discussionmentioning

confidence: 93%

Comparison of Different Glomerular Filtration Methods in the Elderly: Which Formula Provides Better Estimates?

et al. 2012

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Objectives: Technetium-99m diethylenetriaminepentaacetic acid ( 99m Tc-DTPA) is an ideal radioisotopic method having a high correlation with inulin clearance for the determination of glomerular filtration rate (GFR). Different formulas like creatinine clearance (CrCl) in 24 h urine samples, Cockroft-Gault formula (CGF), and modification of diet in renal disease (MDRD) are being used to come up with an estimate. In this study, we compared 99m Tc-DTPA with the formulas mentioned above in an attempt to best identify the method that would yield the nearly ideal GFR estimates in the elderly. Materials and methods:In 76 patients who were admitted to our clinic, we measured 24 h urine volume (V), urine creatinine (Ucr), and serum creatinine (Scr) levels together with CrCl, Scr, serum urea (Su), and albumin (Alb) levels. By using coefficients identified for age, gender, and race, we calculated modification of diet in renal disease 1 (MDRD1). Different from MDRD1, we calculated modification of diet in renal disease 2 (MDRD2) that does not include Su and Alb parameters and formulas like CGF that include Scr, age, gender, and weight parameters to come up with GFR levels. All patients underwent 99m Tc-DTPA procedure. Results: The mean of the GFR values measured by 99m Tc-DTPA was 54.3 ± 19.9. The means of GFR values calculated by CrCl, MDRD1, MDRD2, and CGF were 58.0 ± 30.5, 60.9 ± 22.1, 54.4 ± 20.1, and 57.9 ± 22.4, respectively. GFR as measured by 99m Tc-DTPA showed statistically significant correlations with the results of other methods (p < 0.001 for all methods). The most significant correlation was with MDRD1. Conclusion: MDRD1 can be used for next to ideal and accurate predictions of GFR in the elderly in the daily practice.

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Section: Discussionmentioning

confidence: 93%

Comparison of Different Glomerular Filtration Methods in the Elderly: Which Formula Provides Better Estimates?

et al. 2012

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“…The use of 99mTc-DTPA to determine the GFR in kid ney transplant recipients has been shown to be an accu rate method to assess the transplant function and corre lates well with the inulin clearance [4], Edward et al [1] demonstrated that the measured creatinine clearance (short-term in hospital) overestimated 99mTc-DTPA GFR by a mean of 38%. In the 48 patients we studied, the mea sured creatinine clearance (short-term in hospital) overes timated the 99mTc-DTPA GFR by 19.7 ml/min/1.73 m2 ( fig.…”

Section: Discussionmentioning

confidence: 98%

Comparison of Three Different Methods of Estimating the Glomerular Filtration Rate in Children after Renal Transplantation

Al-Harbi

Lireman

1997

Am J Nephrol

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In 48 children (aged 3-19 years; 33 males and 15 females), who underwent renal transplantation, the glomerular filtration rates (GFR) estimated from creatinine clearance involving urine collection over 4 h in the hospital under direct supervision and creatinine clearance predicted from plasma creatinine concentrations and height (formula) were compared with the GFR estimated by ^99mTc-diethylenediamine penta-acetate (^99mTc-DTPA) clearance. There was a good correlation between the three methods (r = 0.8). Measured and formula creatinine clearances overestimated the GFR as determined by ^99mTc-DTPA by an average of 19.7 ± (SD) 21.2 and 21.9 ± 22.9 ml/min/1.73 m², respectively. So they should be used with caution to estimate the true GFR. In trying to assess the influence of ciclosporin on creatinine secretion by renal tubules, we compared creatinine clearance in two groups of patients with similar GFR as measured by ^99mTc-DTPA, and there was no significant difference in the mean values (p < 0.54) among patients on ciclosporin and azathioprine and on azathioprine alone. It seems, therefore, that ciclosporin did not cause an increased tubular secretion of creatinine leading to an overestimation of the GFR.

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“…While the major source of inaccuracy with scintigraphic methods is due to errors in estimating renal depth [14], this has been eliminated in our study as we compared GFRs of the native kidney twice in the same individual. This method was earlier compared with the GFR obtained by plasma clearance of " mTc-DTPA and was found to correlate significantly (r = 0.75) [15], When compared with inulin clearance, the correlation was bet ter (r = 0.912) [ 16], In a study where a varying amount of protein was used to measure renal functional reserve, it was found that the maximal increase of GFR is around 20% [ 17], This is in agreement with our observation.…”

Section: Discussionmentioning

confidence: 99%

Renal Functional Reserve in Kidney Donors Assessed in Different Settings Using Scintigraphy

George

John²,

Oommen³

et al. 1996

Nephron

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Glomerular filtration rate (GFR) was measured in 9 voluntary male kidney donors by scintigraphy. In the basal state, the mean GFR was 96.1 ± 22 ml/ min/1.73 m². Four weeks after donor nephrectomy, the GFR of the remaining kidney had increased by 22.8 ± 20.7% (p < 0.05). A protein meal given at this time failed to significantly augment the GFR. The GFR of the grafted kidney increased by 59.7 ± 24.4% after 6 months (p < 0.01). Renal functional reserve was thus demonstrated in the remaining kidney and the allograft, though a further reserve could not be elicited in the remaining kidney.

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Comparative Evaluation of Quantitative Glomerular Filtration Rate Measured by Isotopic and Nonisotopic Methods

Cited by 28 publications

References 0 publications

Comparison of Different Glomerular Filtration Methods in the Elderly: Which Formula Provides Better Estimates?

Comparison of Different Glomerular Filtration Methods in the Elderly: Which Formula Provides Better Estimates?

Comparison of Three Different Methods of Estimating the Glomerular Filtration Rate in Children after Renal Transplantation

Renal Functional Reserve in Kidney Donors Assessed in Different Settings Using Scintigraphy

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