Renal Functional Reserve in Kidney Donors Assessed in Different Settings Using Scintigraphy

Abstract

Glomerular filtration rate (GFR) was measured in 9 voluntary male kidney donors by scintigraphy. In the basal state, the mean GFR was 96.1 ± 22 ml/ min/1.73 m². Four weeks after donor nephrectomy, the GFR of the remaining kidney had increased by 22.8 ± 20.7% (p < 0.05). A protein meal given at this time failed to significantly augment the GFR. The GFR of the grafted kidney increased by 59.7 ± 24.4% after 6 months (p < 0.01). Renal functional reserve was thus demonstrated in the remaining kidney and the allograft, though a further reserve could not be elicited in the remaining kidney.

Bone broth ingestion and acute kidney injury following kidney transplant: a role for cystatin C

“…When six healthy volunteers were given a meat broth (creatinine 4334 µmol/L), and creatinine clearance was measured 4 hours later, it was supraphysiological, with a mean of 267±198 mL/min 8. The same phenomenon occurred in donors and recipients when GFR was measured by radionucleotide scintigraphy 9. Fasting for 12 hours has been demonstrated to decrease GFR when measured via isotope glomerular filtration testing from 97 to 88 10.…”