Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats

Abstract

Background Anogeissus latifolia Wall. (A. latifolia) bark has been traditionally used in the treatment of various diseases which includes diabetes and general debility. The present study was aimed to investigate the comparative hypoglycemic and hypolipidemic activity of various extracts of A. latifolia bark in streptozotocin-induced type 1 diabetic rats. Methods Acute toxicity was carried out at 2 g/kg dose of petroleum ether extract of A. latifolia bark (PEALB), chloroform extract of A. latifolia bark (CEALB) and methanol extract of A. latifolia bark (MEALB) in rats. Diabetes was induced by streptozotocin (STZ, 60 mg/kg, i.p.) and it was confirmed at 72 h. Diabetic rats received above extracts at 100 and 200 mg/kg doses for 28 days. Body weight and blood glucose level were determined at every week after the treatment schedule. Serum biochemical parameters and lipid profile levels were estimated at the end of the study. Results PEALB, CEALB and MEALB were non-toxic and no death was observed at 2 g/kg dose. Administration of MEALB at 100 and 200 mg/kg showed significant (p< 0.01, p< 0.05) improvement in body weight and reduction in blood glucose at third and fourth week of treatment. Altered serum biochemical parameters and lipid profiles level were brought to near normal level significantly (p<0.001) compared to diabetic control rats after the administration of both doses of MEALB. However, PEALB and CEALB did not exhibit significant hypoglycemic and hypolipidemic activity. Conclusions Our findings revealed that long-term (28 days) treatment of MEALB possesses significant hypoglycemic and hypolipidemic activity compared to PEALB and CEALB in type 1 diabetic rats and given evidence to the traditional use of A. latifolia bark in diabetes.

Analysis of Job Satisfaction on Employee Engagement Impacted on Turnover Intentions at PT Hilti Nusantara’s Account Manager

“…Research conducted by Affini and Surip [6] showed that job satisfaction directly affects employee engagement. The study results are consistent with research conducted by Kattili et al [7] that showed that job satisfaction positively affects employee engagement (Fig. 1).…”

Antidiabetic and Antihyperlipidaemic Activity of Nelumbo Nucifera Gaertn Ethanol Seed Extract in Streptozotocin Induced Diabetic Rats

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<p>The Effect of Chilgoza Pine Nut (<em>Pinus gerardiana</em> Wall.) on Blood Glucose and Oxidative Stress in Diabetic Rats</p>

“…18 Previous studies have demonstrated that STZ injection significantly reduces body weight, which is associated with an increase in serum glucose level and impaired insulin and lipid profiles. 19 In this study, SOD activity levels in the serum and liver of diabetic rats were decreased significantly compared to the control group, but a significant dosage-dependent increase was observed in the diabetic rats treated with PG compared to the control group. STZ-induced diabetes exacerbated tissue damage by reducing the activity of endogenous antioxidant enzymes.…”