Comparative Evaluation of GR 69153, a Catechol-Substituted Cephalosporin

Abstract

The in vitro activity of GR 69153, a new catechol-containing cephalosporin, was compared with other commonly used antibacterial agents against 651 isolates of Enterobacteriaceae, 204 isolates of other Gram-negative bacilli, and 435 isolates of Gram-positive cocci. The minimum inhibitory concentrations of GR 69153 against 90% of tested strains (MIC90S) of Enterobacteriaceae, including the notoriously resistant Serratia marcescens, were between < 0.03 and 1.0 mg/L. It was the most effective of the drugs tested against Pseudomonas aeruginosa. All 170 isolates of methicillin-susceptible Staphylococcus aureus were inhibited at a GR 69153 concentration of 1.0 mg/L. Like other members of its class, it had little or no activity against Xanthomonas, methicillin-resistant S. au reus and enterococci.