Comparative evaluation of efficiency of serum IGF-1, hand-wrist radiographs, and cervical vertebrae as skeletal maturity indicator

Phogat, Ritu; Sidhu, Maninder Singh; Grover, Seema; Dabas, Ashish; Malik, Vikas; Diwakar, Rohan

doi:10.1177/0974909820150405

Cited by 1 publication

(7 citation statements)

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“…The levels of IGF-1 were evaluated in blood spot by two studies—namely Masoud (2008) and Sharmada et al (2014)—and serum by 10 studies—namely Dhoka et al (2019), Gupta et al (2012, 2015), Ishaq et al (2012), Jain et al (2013), Nancy et al (2019), Phogat et al (2015), Sadiq et al (2020) and Sinha et al (2014, 2016). Srinivasan and Premkumar (2012) and Venkatagiriappa et al (2016) assessed the DHEA levels in serum and blood spot, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The remaining four studies-namely Dhoka et al (2019), Gupta et al (2012), Phogat et al (2015) and Singh et al (2019)-evaluated skeletal maturity status using both HW radiographs and lateral cephalograms. Although all four studies applied the CS staging by Baccetti et al (2005), three of them-namely Dhoka et al (2019), Gupta et al (2012) and Singh et al (2019)-used the Rajagopal and Kansal (2002) method of assessment of HW radiographs while Phogat et al (2015) applied the Fishman staging Fishman (1982).…”

Section: General Characteristics Of Included Studiesmentioning

confidence: 99%

“…The type of sample, timing of collection, type of biomarker and the biomarker detection technique for the 19 studies are described in Table 2. Different biomarkers such as IGF-1, Gupta et al (2012Gupta et al ( , 2015, Ishaq et al (2012), Jain et al (2013), Nancy et al (2019), Phogat et al (2015), Sadiq et al (2020) and Sinha et al (2014Sinha et al ( , 2016. Srinivasan and Premkumar (2012) and Venkatagiriappa et al (2016) assessed the DHEA levels in serum and blood spot, respectively.…”

Section: Characteristics Of the Biomarkersmentioning

confidence: 99%

“…Over the years, various researchers have developed several methods to determine the individual’s skeletal maturity status. Some of the potential predictors of the growth spurt include chronologic age, sexual maturation characteristics, height and weight, or dental development (Phogat et al, 2015). However, the methods involving these changes may be unreliable (Baccetti et al, 2003; Hägg and Taranger, 1982; Hunter, 1966).…”

Section: Introductionmentioning

confidence: 99%

“…and Venkatagiriappa et al (2016); enzyme-linked immunosorbent assay by 11 studies namely Anusuya et al (2020), Dhoka et al (2019), Hussain et al (2013), Ishaq et al (2012), Jain et al (2017), Nancy et al (2019), Sadiq et al (2020), Sharmada et al (2014), Sinha et al (2016),Srinivasan and Premkumar (2012) andTripathi (2017); and chemiluminescence enzyme immunoassay by five studies, namelyGupta et al (2012Gupta et al ( , 2015;Jain et al (2013);Phogat et al (2015) andSinha et al (2014). However,Singh et al (2019) performed the histochemical assessment of serum calcium levels instead.…”

mentioning

confidence: 99%

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Serum biomarkers associated with radiographic skeletal maturity indicators: A systematic review and meta-analysis

et al. 2022

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Objective: To evaluate the relevant scientific literature to determine the association between different serum biomarker levels and radiographic skeletal maturity indicators. Data Search, Screening and Eligibility: A literature search was carried out on PubMed, Cochrane Library, Google Scholar, Semantic Scholar, Science Direct and Opengrey.eu up to November 2021 and 7466 records were retrieved via the electronic search. Study selection, data extraction and subsequent risk of bias assessment (RoB) was carried out independently by two authors. In case of any discrepancy, a third author was consulted. Results: After the exclusion of duplicates and the application of inclusion exclusion criteria, 19 studies (published in 25 articles) were included in the systematic review out of which 17 had a cross-sectional and two had a cohort study design. For the meta-analysis, based on the homogeneity, five cross-sectional studies measuring serum IGF-1 levels were incorporated. The meta-analysis revealed that the serum IGF-1 levels peak at the CS4 stage (401.77 ng/mL [333.50 – 470.05]) in the pooled group. However, in the subgroup analysis, it was found that the serum IGF-1 levels peak at CS3 in women (422.82 ng/mL [377.46–468.18]) and CS4 in men (487.04 ng/mL [391.83–582.25]). Conclusion: Among the various biomarkers evaluated, serum IGF-1 was the most associated with different stages of radiographic skeletal maturity indicators with its levels peaking at CS3 in women and CS4 in men.

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