Comparative evaluation of bioactive cements on biomimetic remineralization of dentin

Abstract

Background: This study was designed to quantitatively compare the presence of apatite peaks on demineralized dentin to induced bio-mimetically by bioactive commercial materials. Material and Methods: Dentin slice specimens (n=6) were prepared and demineralized by by17% EDTA for 2 hours. Each disks materials (Theracal, Biodentine, CPP-ACP) were freshly prepared and was maintained in close contact with a demineralized dentin specimen immersed in PBS solution during one week. To evaluation of bioactivity, cements disks (n=6) were prepared from each material and immersed in PBS solution for one week. The bioactivity and remineralization ability was evaluated using FTIR spectroscopy and Scanning Electron Microscopy. The Ca/P ratio of the surface of dentin and cements disks were compared with one -way ANOVA, independent T test and Duncan test (α=0.05). Results: Ca/P weight ratio of Biodentine (187.5) was significantly higher than Theracal (10.10) and Theracal higher than CPP-ACP (0.37) (P=0.008). Demineralized dentin in contact with Test materials, indicated Ca and P peak after 7 days, but not showed statistically differences between the groups (P=0.08). Conclusions: The outcome revealed that bioactive cements and CPP-ACP had bioactivity capability during one week. Biodentine had higher bioactivity between others. Demineralized dentin could be remineralized with bioactive materials.

TheraCal as the material of choice for direct pulp treatment compared to two other materials: MTA and biodentine

“…The result revealed that the bioactive cements and CPP-ACP had bioactivity capability for one week [8] . TheraCal LC and Activa exhibited a low degree of conversion, low calcium ion release, acceptable biocompatibility and moderate antibacterial activity [9] .…”

Comparative evaluation of four different remineralizing agents on dentin surface topography: an invitro study

“…Demineralization of enamel is the first sign of white spot lesion and progression of mineral loss and disintegration by acids lead to dentin involvement. Various agents with different forms to overcome the demineralization challenge (2) .…”

Efficacy of cavity liners with/without atmospheric cold helium plasma jet for dentin remineralization

“…This procedure is performed aiming to be enhanced by the use of ion-releasing cavity liners [6]. The key to success in this approach is to use remineralizing agents during indirect pulp capping [7]. Dentin remineralization is more complex than enamel remineralization due to the presence of higher amounts of organic matrix [7].…”

“…The key to success in this approach is to use remineralizing agents during indirect pulp capping [7]. Dentin remineralization is more complex than enamel remineralization due to the presence of higher amounts of organic matrix [7]. The remineralization process occurs by the growth of the remaining hydroxyapatite crystals in the affected dentin [7].…”

“…Dentin remineralization is more complex than enamel remineralization due to the presence of higher amounts of organic matrix [7]. The remineralization process occurs by the growth of the remaining hydroxyapatite crystals in the affected dentin [7]. Bioactive materials are applied close to the pulp or over the pulpal exposure site as liners for induction and progression of remineralization.…”