Comparative evaluation of antihypertensive drugs in the management of pregnancy-induced hypertension

Patel, Nita; Gadhavi, Mansi K.; Gorasia, Dhaval; Pandya, Manish R

doi:10.5455/2319-2003.ijbcp003412

Cited by 8 publications

(8 citation statements)

References 19 publications

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“…Our review also found that women consuming a balanced diet, including enough energy based on their individual requirements, had lower BP, paralleling current lifestyle recommendations for individuals with high BP (National Institutes of Health 2003).The effect size of 1-3 mmHg was very small compared with using antihypertensive agents (Patel et al 2012). However, the effect was evident in normotensive rather than hypertensive women.…”

Section: Discussionsupporting

confidence: 75%

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Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Gresham

Bisquera

Byles

et al. 2014

Maternal & Child Nutrition

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Dietary intake during pregnancy influences maternal health. Poor dietary practices during pregnancy have been linked to maternal complications. The objective was to determine the effect of dietary intervention before or during pregnancy on pregnancy outcomes. A systematic review was conducted without date restrictions. Randomised controlled trials (RCTs) evaluating whole diet or dietary components and pregnancy outcomes were included. Two authors independently identified papers for inclusion and assessed methodological quality. Meta-analysis was conducted separately for each outcome using random effects models. Results were reported by type of dietary intervention: (1) counselling; (2) food and fortified food products; or (3) combination (counseling + food); and collectively for all dietary interventions. Results were further grouped by trimester when the intervention commenced, nutrient of interest, country income and body mass index. Of 2326 screened abstracts, a total of 28 RCTs were included in this review. Dietary counselling during pregnancy was effective in reducing systolic [standardised mean difference (SMD) -0.26, 95% confidence interval (CI) -0.45 to -0.07; P < 0.001] and diastolic blood pressure (SMD -0.57, 95% CI -0.75 to -0.38; P < 0.001). Macronutrient dietary interventions were effective in reducing the incidence of preterm delivery (SMD -0.19, 95% CI -0.34 to -0.04; P = 0.01). No effects were seen for other outcomes. Dietary interventions showed some small, but significant differences in pregnancy outcomes including a reduction in the incidence of preterm birth. Further high-quality RCTs, investigating micronutrient provision from food, and combination dietary intervention, are required to identify maternal diet intakes that optimise pregnancy outcomes.

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Section: Discussionsupporting

confidence: 75%

“…The effect size of 1–3 mmHg was very small compared with using antihypertensive agents (Patel et al . ). However, the effect was evident in normotensive rather than hypertensive women.…”

Section: Discussionmentioning

confidence: 97%

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Gresham

Bisquera

Byles

et al. 2014

Maternal & Child Nutrition

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“…7,8 In contrary to this study, Patel NK et al, have proved that labetalol has better efficacy than nifedipine in nonsevere preeclampsia. 9 In the same study by Bharathi et al both the drugs had side effects but they were higher in nifedipine group. Similar to our study the most common side effect with nifedipine was headache.…”

Section: Discussionmentioning

confidence: 86%

Comparative study of labetalol and nifedipine in management of non- severe preeclampsia and its fetomaternal outcome

Rose¹,

Jeyarani²

2019

Int J Reprod Contracept Obstet Gynecol

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Background: In developed countries, 16 percent of maternal deaths were attributed to hypertensive disorders. Of hypertensive disorders, the preeclampsia syndrome, either alone or superimposed on chronic hypertension, is the most dangerous. The incidence of preeclampsia in nulliparous populations ranged from 3 to 10 percent.Methods: The present study was conducted at Government Raja Mirasudhar Hospital, Thanjavur Medical College, Thanjavur, Tamil Nadu, India from October 2017 to October 2018. The study consisted of 100 antenatal women with non-severe preeclampsia. The efficacy of labetalol verses nifedipine in its management was studied along with the fetomaternal outcome.Results: In this study, in the labetalol and in the nifedipine groups adequate control of blood pressure was achieved. However, labetalol was well tolerated by our women without much side effects.Conclusions: The present study indicates both labetalol and nifedipine are equally efficacious in the control of hypertension in non-severe preeclampsia. Pathology of the disease was not altered significantly in both the groups. There was no significant difference in the neonatal outcome between the two groups.

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“…15 In the present study, only one (3.33%) patient developed severe hypertension in labetalol group, while 2 (6.66%) patients in the methyldopa group developed severe hypertension, but there was no statistically significant difference between two groups (p value=1). In the present study, none of the patients developed other complications like eclampsia, abruption and severe pre-eclampsia.…”

Section: Discussionmentioning

confidence: 52%

Safety and efficacy of methyldopa and labetalol in controlling blood pressure in hypertensive disorders of pregnancy

Pentareddy

Shailendra

Prasuna

et al. 2017

Int J Basic Clin Pharmacol

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Background: Hypertensive disorders represent the most common medical complication of pregnancy, with a reported incidence of 6-10% and accounts for 15% of maternal mortality. Effective management of pregnancy induced hypertension is vital to improve maternal and foetal outcomes. As data are scarce on comparison of labetolol and methyldopa this study was undertaken. The objective of present study is compare the efficacy and safety of Labetalol versus Methyldopa in the management of Mild to Moderate pregnancy induced hypertension. To evaluate effect of both drugs on maternal and foetal outcomes.Methods: A comparative observational study is designed. 30 patients who received methyldopa and 30 patients who received labetalol were included in the study. Methyldopa was started at a dose of 250-500 mg thrice daily while labetalol was started at a dose of 100-400 mg twice daily. Patients were followed up during antenatal, intrapartum and postpartum period for efficacy, safety, maternal, and perinatal outcomes.Results: Methyldopa and Labetalol reduced mean systolic and mean diastolic blood pressures significantly. safety profile of both drugs was similar. Spontaneous vaginal deliveries were observed more with labetolol significantly.Conclusions: Labetalol is equally efficacious as methyldopa and well tolerated in the treatment of new onset hypertension during pregnancy.

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Comparative evaluation of antihypertensive drugs in the management of pregnancy-induced hypertension

Cited by 8 publications

References 19 publications

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Effects of dietary interventions on pregnancy outcomes: a systematic review and meta‐analysis

Comparative study of labetalol and nifedipine in management of non- severe preeclampsia and its fetomaternal outcome

Safety and efficacy of methyldopa and labetalol in controlling blood pressure in hypertensive disorders of pregnancy

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