Comparative evaluation of antidiabetic potential of partially purified bioactive fractions from four medicinal plants in alloxan-induced diabetic rats

Bansode, Twinkle; Salalkar, B. K.; Dighe, Pandurang; Nirmal, S. A.; Dighe, Santosh B

doi:10.4103/ayu.ayu_18_17

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Another study carried out in an experimental model of DM2, induced by treatment with alloxan, a diabetogenic chemical agent (Awar et al, 2016), showed that treatment with Syzygium cumini seed extract promoted antidiabetic activities and antihyperglycemic effect, showing is a potent and safe ally for the treatment of T2DM (Bansode et al, 2017). Similar to what was previously observed in an in vitro study with L6 myogenic cells, where Syzygium cumini promoted increased expression of phosphoinositide 3 (PI3) kinase, an essential enzyme in insulin signaling.…”

Section: Syzygium Cumini Lsupporting

confidence: 70%

Therapeutic potential of flavonoid-rich plants in the treatment of arterial hypertension and diabetes mellitus: focus on antioxidant role

Silva

Barbosa

Rocha

et al. 2022

RSD

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Introduction: Chronic non-communicable diseases are the main causes of morbidity and mortality today, among them, Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM), which are responsible for a variety of systemic complications. Both conditions share, in their pathophysiology, the state of oxidative stress, justifying the possible use of antioxidant components, such as flavonoids. Objectives: To characterize and describe the therapeutic potential of the main medicinal plants of popular use, rich in flavonoid-type antioxidant constituents, in the treatment of hypertension and diabetes. Methodology: An integrative literature review study, developed from a survey in PubMed, MEDLINE and LILACS databases. Results: From the survey, the following plants used for hypertension stood out: Hibiscus sabdariffa, Allium sativum L., Phyllathus amarus, Ginkgo biloba and Matricaria chamomilla. As for diabetes, the following stand out: Syzygium cumini L., Caesalpinia sappan, Andrographis paniculata and Curcuma longa L. Conclusion: The results showed that the use of medicinal plants rich in flavonoids can serve as an important ally in the prevention, control and treatment. of SAH and T2DM, acting mainly against the state of oxidative stress, a common pathophysiological mechanism in both diseases, and thus preventing the occurrence of complications resulting from this state.

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Section: Syzygium Cumini Lsupporting

confidence: 70%

Therapeutic potential of flavonoid-rich plants in the treatment of arterial hypertension and diabetes mellitus: focus on antioxidant role

Silva

Barbosa

Rocha

et al. 2022

RSD

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“…Several studies reported that alloxan is a non-ideal diabetogenic agent [ 14 , 15 ]. However, many studies have successfully used this agent [ 31 , 32 ]. Various antidiabetic candidates were assessed using alloxan-induced diabetic rats [ 29 , [33] , [34] , [35] ].…”

Section: Discussionmentioning

confidence: 99%

Self-recovery in diabetic Sprague Dawley rats induced by intraperitoneal alloxan and streptozotocin

Fajarwati¹,

Solihin²,

Wresdiyati³

et al. 2023

Heliyon

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“…Acute in-vivo studies of ethanol extract (100 mg/kg p.o.) of Syzygium cumini seeds in alloxan-induced diabetic rats showed a decrease in serum glucose level by 88mg/dl as compared to Gibenclamide (97mg/dl) (Bansode et al, 2017). In another study, in-vivo antidiabetic activity of chloroform, methanol and aqueous extracts of Syzygium cumini seeds were assessed histologically in streptozotocin (STZ) induced diabetic mice and the results revealed restoration of normoglycemia, increase in G6PD, Plasma insulin and C-Peptide levels in the chloroform extract (Dusane and Joshi, 2011).…”

Section: Antidiabetic Activitymentioning

confidence: 94%

Bioactive compounds and antioxidant activitity in different extracts of sea buckthorn

Sharma

Oberoi

Sharma

et al. 2020

Ann.UDJG.FoodTechnology

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Syzygium cumini (S. cumini) is an underutilized fruit of tropical and subtropical regions with various bioactive compounds distributed in all parts of the plant. The fruit and its by-products, such as seeds, have both nutritional and medicinal value. However, fruit and seeds have not been fully considered as potential functional food ingredients to develop foods with promising health benefits. Based on the available information in the literature, fruit and seed are rich in phytochemicals, such as myricetin, oxalic acid, gallic acid, citronellol, cyanidin diglucoside, hotrienol, phytosterols, flavonoids, carotenoids and polyphenols as well as micronutrients. In addition, they were reported to possess several beneficial health properties. Further, research in this area would provide valuable information for their potential utilization as functional food ingredients. This review presents comprehensive information about the bioactive compounds and nutraceutical properties of S. cumini fruit and seeds, as well as the potential of using them as functional food ingredients

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Comparative evaluation of antidiabetic potential of partially purified bioactive fractions from four medicinal plants in alloxan-induced diabetic rats

Cited by 6 publications

References 25 publications

Therapeutic potential of flavonoid-rich plants in the treatment of arterial hypertension and diabetes mellitus: focus on antioxidant role

Therapeutic potential of flavonoid-rich plants in the treatment of arterial hypertension and diabetes mellitus: focus on antioxidant role

Self-recovery in diabetic Sprague Dawley rats induced by intraperitoneal alloxan and streptozotocin

Bioactive compounds and antioxidant activitity in different extracts of sea buckthorn

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