Comparative evaluation of a novel herbal anesthetic gel and 2% lignocaine gel as an intraoral topical anesthetic agent in children: Bilateral split-mouth, single-blind, crossover in vivo study

Mohite, Vedangi; Baliga, Sudhindra; Thosar, Nilima; Rathi, Nilesh; Khobragade, Pramod; Srivastava, Rashi

doi:10.4103/jisppd.jisppd_226_20

Cited by 7 publications

(12 citation statements)

References 21 publications

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“…Fear and anxiety are the most prevalent problems in pediatric dentistry. Needle phobias most precisely, fear of pain due to needle prick is most frequently encountered in a child, which compromises their dental health [ 9 ]. Hence, various pharmacological and non-pharmacological methods have been developed to overcome this problem.…”

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6–10 years: a randomized control study

Havale¹,

Rao²,

Shrutha³

et al. 2021

J Dent Anesth Pain Med

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Background In the field of dentistry, topical anesthetics play an important role in reducing pain during needle pricks. The anesthetic property of betel leaves remain unexplored, even though they have been widely used for the treatment of various ailments. The purpose of this study was to compare and evaluate pain perception following topical application of lignocaine gel, clove gel, ice, and newly developed betel leaf extract gel during intraoral injection in children. Methods Sixty children aged 6–10 years who met the inclusion criteria were divided into four groups. Topical anesthetic agents, 2% lignocaine (Lox-2% Jelly, Neon, Mumbai, India), 4.7% clove gel (Pain Out Dental Gel, Colgate Palmolive India Ltd, Solan, India), 10% betel leaf extract gel, and ice were applied to each group for one min, followed by administration of infiltration anesthesia. Pain perception was analyzed during needle insertion. The Wong Bakers FACES pain rating scale (WBFPRS) was used for subjective assessment and the Sound, Eye, Motor (SEM) scale for objective assessment. Recorded values were tabulated and subjected to appropriate statistical analysis using SPSS software with a P value set at 0.05. Results The clove oil and betel leaf groups demonstrated the highest WBFPRS scores, followed by the ice and lignocaine groups. The clove, betel leaf extract, and ice groups showed equal and highest SEM scores, followed by the lignocaine group. The mean WBFPRS and mean SEM scores were statistically significant. Conclusion Betel leaf extract gel is effective in reducing pain and can act as an alternative topical anesthetic agent.

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Section: Discussionmentioning

confidence: 99%

“…The WBFPRS and SEM scales used in the present study were previously evaluated in many studies [ 2 3 9 ]. WBFPRS was used because it is simple to understand and can be used easily in younger age groups.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6–10 years: a randomized control study

Havale¹,

Rao²,

Shrutha³

et al. 2021

J Dent Anesth Pain Med

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“…Fear and anxiety are the most prevalent problems in pediatric dentistry; fear of pain due to a needle stick is most often found in a child, which compromises their dental health [1,2,3] . It is psychologically and clinically beneficial to apply some topical anesthetic agent before injecting any type of intraoral anesthesia [4] .…”

Section: Introductionmentioning

confidence: 99%

Topical anesthetics in pediatric dentistry: A literature review

Alvarez¹,

Romero²,

Gonzalez³

et al. 2022

Int. J. Appl. Dent. Sci.

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Introduction: Topical anesthetics are of great interest in pediatric dentistry because they act on the peripheral nerves reducing the sensation of pain when applying local anesthetics. Objective: To analyze the most recent literature on topical anesthetics: benzocaine, lidocaine, eutectic mixture of local anesthetics (EMLA), generalities, doses and presentations, uses and adverse effects. Methodology: Articles on topical anesthetics in pediatric dentistry were analyzed in the databases PubMed, SCOPUS and Google academic with emphasis on the last 5 years. This was done with the words: "dental anesthetic", "benzocaine", "lidocaine", "Pediatric dentistry", "EMLA". Results: It has been found that 20% benzocaine is the most used anesthetic, its main use is before local anesthetic puncture, it has a pleasant taste, however, high rates of allergies have been reported. As for lidocaine, it is effective when applied in 1 minute, its 10% aerosol presentation has presented the best results, its toxicity levels are low but it has an unpleasant taste. EMLA is a mixture of lidocaine 2.5% and prilocaine 2.5%, it is used before puncture, when placing orthodontic separators and in small biopsies, its application time is 2 to 10 minutes and it can cause numbness in unwanted areas. Conclusion: Currently there is no topical formulation that completely eliminates the pain caused by needle puncture, therefore, products with greater efficacy are awaited.

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“…Animal fat‐based creams containing A. pyrethrum as a main ingredient were being used to treat sciatica and gout 12 . The gel of root of Anacyclus pyrethrum showed the same activity as the 2% lignocaine gel in reduction of pain 13 . In a study conducted in mice to assess the anti‐inflammatory properties of Anacyclus pyrethrum revealed that the methanolic extracts and aqueous extracts (62%) of roots shows greater anti‐inflammatory activity than that of indomethacin (49%) 14 …”

Section: Introductionmentioning

confidence: 99%

Formulation and characterization of Anacyclus Pyrethrum Emulgels and its in vitro and in vivo evaluation as cosmeceutical product

Qureshi

Jamil

Akhtar

et al. 2022

J of Cosmetic Dermatology

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Background Plants containing high phenolic and flavonoids contents used widely as antioxidant agent by reducing skin photo damaging effects and play important role in skin rejuvenating. Aims This study was performed to explore the cosmetic effects of Anacyclus Pyrethrum extract and to develop stable oil in water (O/W) emulsion base gel loaded with Anacyclus Pyrethrum 10% extract. Objective To explore and quantify phenols and flavonoids present in Anacyclus Pyrethrum extract and determine its cosmetic effects on human skin. Method Emulgel formulation were developed by mixing o/w emulsion with carbopol gelling agent loaded with Anacyclus Pyrethrum (AP) extract and base gel without AP extract. In vitro study was done for the evaluation of color change, liquefaction, hardness, and pH change at different storage condition for the duration of 12 weeks. For in vivo study, emulgel applied on 13 healthy human volunteer's cheeks to evaluate its cosmetics effects and compared with placebo (base). Facial parameters including skin melanin, redness, sebum, moisture content, and skin elasticity were determined by using mexameter, sebumeter, corneometer, elastometer for the study duration of 12 weeks. Results Total phenolic content in Anacyclus Pyrethrum extract was 80.04 ± 0.0043 mg GAE/g, and flavonoids were 54.64 ± 0.0076 mg QE/g. Anacyclus Pyrethrum extract found significantly effective in reducing skin photo‐damage effects (p ≤ 0.05) as compared base gel. Conclusion Anacyclus Pyrethrum extract being rich source of flavonoid and phenolic content, acts as strong antioxidant to protect skin against photo‐damaging effect and improve skin conditions.

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Comparative evaluation of a novel herbal anesthetic gel and 2% lignocaine gel as an intraoral topical anesthetic agent in children: Bilateral split-mouth, single-blind, crossover in vivo study

Cited by 7 publications

References 21 publications

Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6–10 years: a randomized control study

Comparative evaluation of pain perception following topical application of clove oil, betel leaf extract, lignocaine gel, and ice prior to intraoral injection in children aged 6–10 years: a randomized control study

Topical anesthetics in pediatric dentistry: A literature review

Formulation and characterization of Anacyclus Pyrethrum Emulgels and its in vitro and in vivo evaluation as cosmeceutical product

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