Comparative Evaluation of 3-Dimensional Pseudocontinuous Arterial Spin Labeling With Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Human Glioma

Roy, Bhaswati; Awasthi, Rishi; Bindal, Amit Kumar; Sahoo, Prativa; Kumar, Rajan; Behari, Sanjay; Ojha, Bal Krishna; Husain, Nuzhat; Pandey, Chandra M.; Rathore, Ram K.S.; Gupta, Rakesh K.

doi:10.1097/rct.0b013e318282d7e2

Cited by 44 publications

(42 citation statements)

References 28 publications

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“…Our finding was consistent with the previous study reported by Roy et al [16], which showed that 3D pCASL MRI could not be regarded as a reliable technique in the grading of gliomas. The CBF value quantified by pCASL method was influenced by a number of factors such as arterial transit time, inversion efficiency and the magnitude of the error [16]. These unsatisfied results may be caused by the inaccurate quantifications of CBF values [16].…”

Section: Discussionsupporting

confidence: 92%

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Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

et al. 2016

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Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas.

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Section: Discussionsupporting

confidence: 92%

“…Currently, the pCASL tagging method provides the best signal-to-noise ratio [15]. The previous study has been used the 3D pCASL MRI method to evaluate the grading of gliomas [16]. …”

Section: Introductionmentioning

confidence: 99%

Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

et al. 2016

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“…10,11 If our imaging findings are considered, the diagnostic performance of ASL is better than that indicated by these previous studies.…”

Section: Discussionmentioning

confidence: 47%

Clinical Significance of Discrepancy between Arterial Spin Labeling Images and Contrast-enhanced Images in the Diagnosis of Brain Tumors

et al. 2015

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Purpose: In the imaging of intra-axial brain tumors, we sometimes found areas of high signal intensity around the enhanced tumor lesions on arterial spin labeling (ASL) magnetic resonance (MR) imaging. We undertook this study to investigate the relationship between high signal intensity on ASL imaging outside the area of contrast enhancement (CE) and histological diagnosis of intra-axial brain tumors.Methods: We examined images from 28 consecutive patients with intra-axial brain tumors who underwent ASL and CE MR imaging-three with low grade glioma (LGG), 13 with high grade glioma (HGG), six with metastasis, and six with primary central nervous system lymphoma (PCNSL)-and divided imaging findings into an "ASL dominant" group when hyperintensity on ASL was found outside the CE area and a "CE dominant" group when hyperintensity on ASL was not found outside the area of enhancement. We then analyzed the relationship between imaging findings and the histological diagnosis of the tumors.Results: Four cases were excluded because of poor quality of ASL images, 7 cases were classified as ASL dominant, and 17 cases were classified as CE dominant. The histological diagnoses of ASL dominant cases were LGG in 3 cases, HGG in 3 cases, and PCNSL in one case. Those of CE dominant cases were HGG in 10 cases, metastasis in 5 cases, and PCNSL in 2 cases. All cases with brain metastasis were classified as CE dominant.Conclusion: The high signal intensity outside the area of contrast enhancement is probably caused by increased perfusion or vascular proliferation, which indicates the presence of glioma or PCNSL and not metastasis. This finding indicates a new utility for ASL images in the diagnosis of brain tumors as a supplement to the conventional measurement of perfusion obtained from ASL images.

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“…However, a previous study indicated that pCASL-derived CBF maps were unable to grade gliomas, in contradiction to our results. 21 In that study, compared with relative CBF derived from the dynamic contrast-enhanced MR imaging, the ASL-derived relative CBF was found to be relatively higher in…”

Section: Discussionmentioning

confidence: 99%

“…9,16,17 However, although pseudocontinuous ASL (pCASL) is considered an improved method over pulsed ASL and CASL, [18][19][20] a recent study reported that pCASL-derived CBF maps failed to accurately grade gliomas. 21 On the other hand, according to many previous studies, gliomas with higher tumor blood flow are commonly more malignant. [8][9][10][11][12][13][14][15][16][17] However, a recent study found a positive correlation between proliferation activity and levels of a hypoxia biomarker in glioblastoma (GBM), 22 suggesting that GBM with a lower blood flow might be more aggressive.…”

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confidence: 99%

3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas

Zeng¹,

Jiang²,

Shi

et al. 2017

AJNR Am J Neuroradiol

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Comparative Evaluation of 3-Dimensional Pseudocontinuous Arterial Spin Labeling With Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Human Glioma

Abstract: Three-dimensional pseudocontinuous arterial spin labeling does not appear to be a reliable technique in the current form and may not be a suitable replacement for DCE in grading of glioma.

Cited by 44 publications

References 28 publications

Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

Clinical Significance of Discrepancy between Arterial Spin Labeling Images and Contrast-enhanced Images in the Diagnosis of Brain Tumors

3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas

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