Comparative Electrolyte Composition of Parotid, Submandibular, and Sublingual Secretions

Chauncey, Howard H.; Feller, Ralph P.; Henriques, Basil L.

doi:10.1177/00220345660450044001

Cited by 24 publications

(44 citation statements)

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“…Although the composition of human sublingual saliva has not been studied in the same detail as has saliva from the other major glands, it has been found that sublingual saliva has a higher concentration of sodium than would be expected on the basis of secretion rate alone (Chauncey et al, 1966). Based on micropuncture studies of experimental animals and on the morphological resemblance of striated ducts to proximal convoluted tubules, it has been suggested that these ducts play an important role in the resorption of electrolytes, principally sodium, from the initial saliva.…”

Section: Figmentioning

confidence: 99%

Ultrastructural observations on human sublingual gland

1988

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That part of the human sublingual gland that corresponds in morphology to the conventional description of this organ presented in most histology texts (probably the major sublingual gland, in contradistinction to the aggregated small glands that compose the minor sublingual glands) was studied by electron microscopy. The gland is mixed, with slightly more mucous elements than seromucous ones. The mucous cells are arranged in tubules that usually are capped by seromucous demilunes. Seromucous cells also form occasional acini or may be scattered in the walls of the mucous tubules. The appearance of the mucous cells varies with the stage of the secretory cycle that they may be in. Their secretory droplets increase in number and progressively compress cytoplasmic organelles. Filamentous bodies also may be present. Based on secretory-granule substructure, four different kinds of seromucous cells can be recognized; these may be a morphological expression of asynchronous synthesis of different secretory proteins. The duct system is an abbreviated one compared to the other major salivary glands. The first duct segments, into which the mucous tubules drain, are similar to intercalated ducts. Larger ducts contain mitochondria-rich cells but lack the basal striations that characterize striated ducts. The paucity of typical striated ducts may be correlated with the elaboration of sodium-rich saliva by the human sublingual gland.

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Section: Figmentioning

confidence: 99%

Ultrastructural observations on human sublingual gland

1988

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“…However, there are some differences in the pH i regulatory mechanisms among species and gland types. In salivary acinar cells, the initial response to a fluid secretion stimulus is an acidification of the cytosol resulting from a HCO 3 Ϫ efflux into the lumen (10,13,19,37), and the secreted HCO 3 Ϫ plays a role in buffering the acid produced by oral bacteria and in providing an optimal pH for salivary amylase activity (6).…”

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confidence: 99%

“…It is known that intracellular HCO 3 Ϫ is generated by carbonic anhydrase, which converts the CO 2 that has freely diffused into the cells from the blood into H ϩ and HCO 3 Ϫ (21). The H ϩ generated during this HCO 3 Ϫ production is then extruded outside the cells by the Na ϩ /H ϩ exchanger (NHE) (19,22,35).…”

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confidence: 99%

Expression of the Na⁺-HCO₃⁻cotransporter and its role in pH_iregulation in guinea pig salivary glands

Jingchao

Koo²,

Cho³

et al. 2006

American Journal of Physiology-Gastrointestinal and Liver Physi

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Patterns of salivary HCO(3)(-) secretion vary and depend on species and gland types. However, the identities of the transporters involved in HCO(3)(-) transport and the underlying mechanism of intracellular pH (pH(i)) regulation in salivary glands still remain unclear. In this study, we examined the expression of the Na(+)-HCO(3)(-) cotransporter (NBC) and its role in pH(i) regulation in guinea pig salivary glands, which can serve as an experimental model to study HCO(3)(-) transport in human salivary glands. RT-PCR, immunohistochemistry, and pH(i) measurements from BCECF-AM-loaded cells were performed. The amiloride-sensitive Na(+)/H(+) exchanger (NHE) played a putative role in pH(i) regulation in salivary acinar cells and also appeared to be involved in regulation in salivary ducts. In addition to NHE, NBC also played a role in pH(i) regulation in both acini and ducts. In the parotid gland, NBC1 was functionally expressed in the basolateral membrane (BLM) of acinar cells and the luminal membrane (LM) of ducts. In the submandibular gland, NBC1 was expressed only in the BLM of ducts. NBC1 expressed in these two types of salivary glands takes up HCO(3)(-) and is involved in pH(i) regulation. Although NBC3 immunoreactivity was also detected in submandibular gland acinar cells and in the ducts of both glands, it is unlikely that NBC3 plays any role in pH(i) regulation. We conclude that NBC1 is functionally expressed and plays a role in pH(i) regulation in guinea pig salivary glands but that its localization and role are different depending on the type of salivary glands.

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“…Saliva is composed of more than 99% water and contains various substances, such as protein, bacteria, enzymes, organic acids, and inorganic substances [1]. Salivary inorganic components comprise mainly Na, K, P, Ca, and bicarbonate ions [2]. Bicarbonate ions can prevent the demineralization of enamel by a buffering action, which maintains a constant salivary pH.…”

Section: Introductionmentioning

confidence: 99%

Study of Salivary Strontium and Silver Concentrations in Primary School Children Related to Dental Caries

Shigemi

Tanaka

Hayashida

et al. 2008

Biol Trace Elem Res

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To investigate the relationship between the salivary Sr and Ag concentrations and tooth conditions, saliva was collected from 521 primary school children in Kitakyushu. The salivary Sr and Ag levels were determined using an atomic absorption spectrophotometry. The salivary Sr and Ag levels were 7.73 +/- 3.62 and 0.03 +/- 0.15 ng/ml, respectively, in the sound teeth group. No sex differences were noted in either element level, nor were there differences between the lower and upper grade groups. In the caries teeth group, the Sr and Ag levels were significantly higher than those in the sound teeth group. The Sr level was significantly increased by caries experience regardless caries being treated or untreated. In second to third grade children, in whom the fluoride experience rate was high, the Sr level tended to be lower than that in the other grades. The salivary Ag level increased as the number of teeth treated with silver alloy rose. These findings suggested that the salivary Sr level increases because of caries susceptibility, and F inhibits Sr dissolution from the teeth. The salivary Ag level varied depending on the type of dental filling and was dependent on the amount of silver alloy in children treated with low-fusing silver alloy.

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Comparative Electrolyte Composition of Parotid, Submandibular, and Sublingual Secretions

Cited by 24 publications

References 0 publications

Ultrastructural observations on human sublingual gland

Ultrastructural observations on human sublingual gland

Expression of the Na⁺-HCO₃⁻cotransporter and its role in pH_iregulation in guinea pig salivary glands

Study of Salivary Strontium and Silver Concentrations in Primary School Children Related to Dental Caries

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Comparative Electrolyte Composition of Parotid, Submandibular, and Sublingual Secretions

Cited by 24 publications

References 0 publications

Ultrastructural observations on human sublingual gland

Ultrastructural observations on human sublingual gland

Expression of the Na+-HCO3−cotransporter and its role in pHiregulation in guinea pig salivary glands

Study of Salivary Strontium and Silver Concentrations in Primary School Children Related to Dental Caries

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Expression of the Na⁺-HCO₃⁻cotransporter and its role in pH_iregulation in guinea pig salivary glands