Study of Salivary Strontium and Silver Concentrations in Primary School Children Related to Dental Caries

Shigemi, Takahiro; Tanaka, Toshiko; Hayashida, Yutaka; Maki, Kenshi

doi:10.1007/s12011-007-8085-4

Cited by 12 publications

(7 citation statements)

References 34 publications

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“…Blood concentration of strontium, phosphate and fluorine was significantly lower in patients with high carious activity in comparison with patients with low carious activity [12]. In saliva, the concentration of strontium was higher in children with caries experience in comparison to the saliva concentration of strontium in children with sound teeth and fluorine was found to inhibit strontium dissolution from teeth during carious attack [13]. Strontium and fluorine can be found in glass-ionomer cements used for bases or restorations of primary and permanent teeth.…”

Section: Introductionmentioning

confidence: 93%

Ion exchanges between glass-ionomer restorative material and primary teeth components-an in vivo study

Zilberman¹

2014

Oral Biol Dent

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Objectives: To analyze the ion exchange between conventional glass-ionomer restorative material, (Fuji IX-GC Co., Japan) and tooth components in primary molars after long periods of function in vivo. Methods: Five deciduous mandibular molars were collected after normal exfoliation. An intact deciduous molar served as control, a second deciduous molar was restored occlusaly with Fuji IX in vitro, and 3 deciduous molars with occlusal restorations were collected after 18, 24, and 48 months in vivo. The molars were sectioned bucco-lingual through the restoration and the chemical analysis was performed on enamel, dentin and restorative material along parallel lines crossing from buccal to lingual, using an energy dispersive X-ray spectrometer (EDS). The data was analyzed using SPSS program. Results: In the enamel adjacent to the glass-ionomer material, calcium and phosphate showed a significant reduction related to time (P<0.05). In both enamel and dentin strontium, silica and alumina migrated from the glass-ionomer material in significant concentrations (P<0.05), and fluorine showed an increase from zero in the intact deciduous molar to 1.2% after four years in vivo. In the glass-ionomer material fluorine was reduced in relation with time in vivo, while calcium concentration increased. Conclusions: There is a constant exchange of ions between glass-ionomer restorative material and tooth components in deciduous molars. It begins as early as two weeks in vitro and is increased in vivo. Strontium, alumina and fluorine released from the glassionomer have a bactericidal effect and may affect remineralization. Calcium may enhance the glass-ionomer mineralization and transform it into enamel like material. Clinical significance: The results showed that a continuous exchange of ions between enamel and dentin and glass-ionomer material occurs in vivo and the concentration of the ions is time related. Strontium, alumina and fluorine in enamel and dentin may cause a continuous anti bacterial and anti cariogenic effect, while calcium enhance mineralization of glass-ionomer in vivo, a factor that may increase the longevity of the restoration.

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Section: Introductionmentioning

confidence: 93%

Ion exchanges between glass-ionomer restorative material and primary teeth components-an in vivo study

Zilberman¹

2014

Oral Biol Dent

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“…Curzon [1984] was able to demonstrate a weak, negative relationship between [Sr] in saliva andon caries prevalence (r = -0.13) in 105 children aged 14 years. In contradiction, during one very recent study [Shigemi et al, 2008] on 521 children aged 6 to 12 years was able to demonstrate a positive correlation between [Sr] in saliva and using the author's terminology 'caries experience' (no DMFT/S scores were recorded) was reported. In addition, the authors showed that in groups with high 'fluoride experience rates' (due to F mouth rinsing at school), [Sr] in saliva tended to be lower.…”

Section: Epidemiological Caries Studiesmentioning

confidence: 89%

Strontium and Caries: A Long and Complicated Relationship

Lippert

Hara²

2012

Caries Res

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Investigations into the role of strontium (Sr) in caries prevention have attracted great interest in the research community in the past, with its peak in the 1970-and 80ies. To this date, no clear indication of the relative importance of Sr in caries prevention has been provided. A vast number of animal caries, epidemiological and mechanistic studies have been conducted. Albeit Although a great level ofthere is much discrepancyexists in the literature, the majority of studies suggest that Sr exhibits some cariostatic properties and, predominantly in the presence of fluoride (F). An optimum Sr concentration of 5 to 10 ppm in drinking water has been proposed as a direct result of several epidemiological caries studies. Despite these results, no direct link can be established between Sr and caries prevention as, to date, no relevant, randomized control trials have been reported. The extrapolation of potential cariostatic properties of Sr from epidemiological studies is difficult due to the co-presence of several other trace elements in the water of the study areas, with many of these elements being attributed cariostatic properties in their own right.

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“…Other studies concerning caries susceptibility with the relation to trace metal concentration in saliva of primary school children have been performed [75]. Additional field of the assessment of exposure to trace elements discussed in the literature were teeth, evaluated to reveal the relation of tooth element content of diabetics and hypertensives [76].…”

Section: Discussionmentioning

confidence: 99%

Cytocompatibility of Medical Biomaterials Containing Nickel by Osteoblasts: a Systematic Literature Review

Mikulewicz

Chojnacka

2010

Biol Trace Elem Res

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The present review is based on a survey of 21 studies on the cytocompatibility of medical biomaterials containing nickel, as assessed by cell culture of human and animal osteoblasts or osteoblast-like cells. Among the biomaterials evaluated were stainless steel, NiTi alloys, pure Ni, Ti, and other pure metals. The materials were either commercially available, prepared by the authors, or implanted by various techniques to generate a protective layer of oxides, nitrides, acetylides. The observation that the layers significantly reduced the initial release of metal ions and increased cytocompatibility was confirmed in cell culture experiments. Physical and chemical characterization of the materials was performed. This included, e.g., surface characterization (roughness, wettability, corrosion behavior, quantity of released ions, microhardness, and characterization of passivation layer). Cytocompatibility tests of the materials were conducted in the cultures of human or animal osteoblasts and osteoblast-like cells. The following assays were carried out: cell proliferation and viability test, adhesion test, morphology (by fluorescent microscopy or SEM). Also phenotypic and genotypic markers were investigated. In the majority of works, it was found that the most cytocompatible materials were stainless steel and NiTi alloy. Pure Ni was rendered and less cytocompatible. All the papers confirmed that the consequence of the formation of protective layers was in significant increase of cytocompatibility of the materials. This indicates the possible further modifications of the manufacturing process (formation of the passivation layer).

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Study of Salivary Strontium and Silver Concentrations in Primary School Children Related to Dental Caries

Cited by 12 publications

References 34 publications

Ion exchanges between glass-ionomer restorative material and primary teeth components-an in vivo study

Ion exchanges between glass-ionomer restorative material and primary teeth components-an in vivo study

Strontium and Caries: A Long and Complicated Relationship

Cytocompatibility of Medical Biomaterials Containing Nickel by Osteoblasts: a Systematic Literature Review

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