Comparative Efficiency of Plasma NGAL (Neutrophil Gelatinase-Associated Lipocalin) in Off-pump and On-pump Cardiac Surgery in the Early Dıagnosis of Acute Renal Injury

Karadeniz, Zafer; Tuncel, Zeliha; Yapıcı, Nihan; Kudsioğlu, Türkan; Coşkun, Fi̇li̇z; Nurac, Hakan; Karaci, Ali Rıza; Karabulut, Sezer; Ukil, Fatma; Ogutmen, Betul; Aykaç, Zuhal

doi:10.5222/gkdad.2013.168

Cited by 1 publication

(1 citation statement)

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“…Animal models of NGAL protein have been shown to increase in renal tubule cells in ischemic and nephrotoxic akute kidney injury, as well as in plasma and urine levels. Protein carbonyl content is the most general and wellused biomarker of severe oxidative protein damage [11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

Gentamisinin İndüklediği Nefrotoksisitede Ozonun Koruyucu Etkisi ve Neutrophil Gelatinase-Associated Lipocalin (NGAL) Düzeyleri: Deneysel Çalışma

Üstebay¹,

Üstebay²,

Öztürk³

et al. 2019

Kafkas Univ Vet Fak Derg

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Our aim was to investigate the protective role of ozone treatment against gentamicin-induced nephrotoxicity in an experimental rat model. In this study, a total of 30 rats were allocated in 5 groups (n=6 in each group). The control group (Group 1) received isotonic saline only, while Groups 2 and 3 received gentamicin at doses of 15 mg/kg/day and 50 mg/kg/day, respectively. In Group 4, intraperitoneal ozone treatment (1 mg/kg, 5% O3-95% O2) was performed after administration of gentamicin at a dose of 15 mg/kg/day. Group 5 underwent ozone treatment intraperitoneally following the application of gentamicin (50 mg/kg/day). Nephrotoxicity was formed by administration of glycerol. Serum levels of urea, creatinine, neutrophil-gelatinase-associated lipocalin (NGAL), lactate dehydrogenase (LDH), total antioxidant capacity (TAC) and protein carbonyl were measured, and kidneys were histopathologically examined after the sacrifice of animals on the 5 th day. Group 4 displayed more favorable outcomes regarding biochemical markers of oxidative stress such as NGAL, LDH, creatinine, urea, TAC and protein carbonyl. Similarly, histopathological alterations indicating gentamicin-induced nephrotoxicity such as hemorrhage, the presence of protein casts and epithelial injury in renal tubules were less evident in Groups 4 and 5 which received ozone treatment. To conclude, results of this experimental study demonstrated that ozone treatment might ameliorate biochemical disturbances and histopathological alterations linked with gentamicininduced nephrotoxicity. However, further trials are warranted to document the actual therapeutic potential of ozone treatment in the clinical setting.

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