Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model

Abstract

Two antimicrobial agents, a fixed combination of essential oils (EOs) and 0.07% cetylpyridinium chloride (CPC) are found in commercially available mouthrinses, Listerine  Antiseptic and Crest  Pro Health  , respectively. Both mouthrinses have been shown to control dental plaque and gingivitis in short and longer term studies. The aim of this study was to determine the comparative effectiveness of these two mouthrinses using a 2-week experimental gingivitis model. Qualified subjects were randomly assigned to one of three mouthrinse groups: a fixed combination of EOs, 0.07% CPC, or negative control (C) rinse. Following baseline clinical assessments and a dental prophylaxis, subjects began a two-week period in which they rinsed twice daily with their assigned rinse and abstained from any mechanical oral hygiene procedures or other oral care products. Subjects were reassessed at the end of the two-week period. One hundred and forty-seven subjects were randomized and 142 completed this study. After two weeks use, the EOs rinse was superior (p ≤ 0.011) to the CPC rinse in inhibiting the development of gingivitis, plaque, and bleeding, with 9.4% and 6.6% reductions compared to CPC for gingivitis and plaque, respectively. Both rinses were superior to the negative control rinse (p < 0.001). This study demonstrates that the essential oil-containing mouthrinse has superior antiplaque/antigingivitis effectiveness compared to the 0.07% CPC-containing mouthrinse without mechanical oral hygiene influence.

Comparison of Effect of Hiora Mouthwash Versus Chlorhexidine Mouthwash in Gingivitis Patients: A Clinical Trial

“…The reduction in amount of plaque found to be statistically significant (p=0.000) well corroborates with the results obtained in the previous studies carried out by Loe [18], and Lang et al [19], and Sharma et al also found significant amount of plaque reduction in the children who used 0.2% chlorhexidine mouthwash [20]. Chlorhexidine has an excellent antiplaque activity and substantivity property [21]. Haq et al [22,23] reported that Cetylpyridinium chloride mouthwash in combination According to an in vitro comparative study on the evaluation of the efficacy of chlorhexidine and a herbal mouthwash on dental plaque, 20 plaque samples were collected from periodontitis patients, and healthy patients were streaked on blood agar.…”

The effect of an essential‐oils mouthrinse as compared to a vehicle solution on plaque and gingival inflammation: a systematic review and meta‐analysis

“…The screening of titles and abstracts initially identified 25 full‐text articles. Fifteen papers were excluded because the alcohol‐containing control rinse had a low hydro‐alcohol concentration of 0.02% or 5% , and in one study, the concentration of the hydro‐alcohol was not provided . In addition, in one study, the control rinse was either a chlorhexidine or sanguinarine rinse , and in two another, a water‐based control was used .…”

Commercial antimicrobials mouthrinses on caries and periodontitis-related biofilm control: a review of literature

“…EO demonstrated significant reduction in MGI (9.4%), PI (6.6%) and BI (29%) compared to CPC. EO presented clinical superiority compared to CPC in the short-term management of plaque and gingivitis [38].…”