Comparative efficacy of three commercial PCV2 vaccines in conventionally reared pigs

Lyoo, Kwang‐Soo; Joo, Heesoo; Caldwell, Brian; Kim, Hyeun Bum; Davies, Peter; Torrison, Jerry

doi:10.1016/j.tvjl.2010.06.015

Cited by 31 publications

(14 citation statements)

References 20 publications

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“…Furthermore, PCV2 vaccines have been highly effective in the field, and almost all pigs are seropositive to PCV2 at the time of PCV2 vaccination (9,19,21,41). In experimental PCV2 challenge models, outcomes are often similar between vaccine treatment groups (11,24), and conclusions often lack power. Passively acquired antibodies in many instances decrease PCV2 viremia and prevent the development of clinical disease under controlled experimental conditions.…”

Section: Discussionmentioning

confidence: 99%

Studies on Porcine Circovirus Type 2 Vaccination of 5-Day-Old Piglets

O'Neill

Shen

Lin

et al. 2011

Clin Vaccine Immunol

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Porcine circovirus type 2 (PCV2) vaccines have become widely used since they became available in 2006. It is not uncommon for producers to use PCV2 vaccines in pigs younger than what is approved by manufacturers. The objective of this study was to determine the efficacy of a chimeric and a subunit PCV2 vaccine administered at 5 or 21 days of age. Forty-eight PCV2-naïve piglets were randomly divided into six groups of eight pigs each. Vaccination was done at day 5 or day 21, followed by triple challenge with PCV2, porcine parvovirus (PPV), and porcine reproductive and respiratory syndrome virus (PRRSV) at day 49. Vaccinated pigs seroconverted to PCV2 approximately 14 days postvaccination and had a detectable neutralizing antibody response by 21 days postvaccination regardless of age at vaccination. At day 49, the pigs vaccinated with the chimeric vaccine had significantly higher levels of neutralizing antibodies than the pigs vaccinated with the subunit vaccine. After challenge, vaccinated pigs had significantly decreased levels of PCV2 viremia and a decreased prevalence and severity of microscopic lesions compared to the positive-control group, which had severe lymphoid lesions associated with abundant PCV2 antigen, compatible with PCV-associated disease. The results of this study indicate that, under the conditions of this study, vaccination of PCV2-naïve pigs at day 5 or day 21 resulted in development of a detectable humoral immune response and provided reduction or complete protection against PCV2 viremia and PCV2-associated lesions after triple challenge with PCV2, PPV, and PRRSV.

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Section: Discussionmentioning

confidence: 99%

Studies on Porcine Circovirus Type 2 Vaccination of 5-Day-Old Piglets

O'Neill

Shen

Lin

et al. 2011

Clin Vaccine Immunol

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“…The principal sequence differences between PCV2a and PCV2b genotypes localize to ORF2, where the nucleotide and peptide sequence identities are approximately 93%. Baculovirus-based vaccines that express PCV2 ORF2 are sufficient to offer protection from disease (4,15,19,31,42,51). ORF1 is 945 nucleotides (nt) in length and codes for two replicase proteins, Rep and RepЈ (12,34).…”

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confidence: 99%

Antibody Recognition of Porcine Circovirus Type 2 Capsid Protein Epitopes after Vaccination, Infection, and Disease

Trible

Kerrigan

Crossland

et al. 2011

Clin Vaccine Immunol

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Open reading frame 2 (ORF2) of porcine circovirus type 2 (PCV2) codes for the 233-amino-acid capsid protein (CP). Baculovirus-based vaccines that express only ORF2 are protective against clinical disease following experimental challenge or natural infection. The goal of this study was to identify regions in CP preferentially recognized by sera from experimentally infected and vaccinated pigs and to compare these responses to those of pigs diagnosed with porcine circovirus-associated disease (PCVAD), including porcine multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS). The approach was to react porcine sera with CP polypeptide fragments followed by finer mapping studies using overlapping oligopeptides that covered amino acids

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“…Studies show that vaccination against PCV2 does not necessarily stimulate capsid-specific antibodies but does seem to be involved in the increase of neutralizing antibodies ( Dvorak et al , 2018). In our study, vaccination against PCV2 using two doses in piglets results in a higher antibody response than a single dose (p<0.05), even though in terms of protection the two options have shown to be effective and control PCV2 viremia ( Lyoo et al , 2011). However, a single dose at 3 weeks of age might interfere with maternal antibodies as described before ( Fort et al , 2009; Fraile et al , 2012; Martelli et al , 2011).…”

Section: Discussionmentioning

confidence: 66%

“…Vaccination of sows seeks to reduce viremia and viral loads in piglets through neutralizing antibodies present in colostrum, and could improve the productive performance of their offspring after weaning ( Beach & Meng, 2012; Gerber et al , 2011; Pejsak et al , 2010). Moreover, vaccination of the piglet is used to induce active humoral and cellular immunity, reduce viral loads, shorten duration of viremia, and improve productive performance ( Fachinger et al , 2008; Fraile et al , 2012; Lyoo et al , 2011; Takahagi et al , 2010). Currently, it is feasible to vaccinate sows, piglets, or both ( Fraile et al , 2012; Opriessnig et al , 2010), although the interference between maternally derived antibodies and active immunity of the piglet is under debate ( Fraile et al , 2012).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal comparison of the humoral immune response and viral load of Porcine Circovirus Type 2 in pigs with different vaccination schemes under field conditions

Vargas-Bermúdez

Díaz²,

Mogollón

et al. 2018

F1000Res

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Porcine Circovirus type 2 (PCV2) infections are distributed Background: worldwide and cause Porcine Circovirus Associated Disease (PCVAD). To minimize the impact of PCV2 infection on swine health and production, different vaccination schemes have been used since 2006. However, the association between vaccination schemes, virus load and disease under field conditions are not completely understood. Therefore, the objective of this study was to compare the effect of two different PCV2 vaccination schemes on the humoral response and PCV2 load in pigs after weaning under field conditions. Two commercial pig farms (Farm A and B), endemically infected Methods: with PCV2, which were using two different PCV2 subunit vaccinations schemes for sow, gilts and piglets, were selected. We designed a longitudinal study and measured IgG levels by ELISA and virus load by quantitative PCR in pigs after weaning. Forty 3-week old piglets were randomly selected at weaning and followed for 20 weeks. IgG levels and virus loads were compared within and between farms and considered statistically different if the non-parametric Kruskal Wallis test p value was lower than 0.05.We found that low virus loads were maintained in pigs from both Results: farms regardless of the vaccination scheme used (p>0.05). However, there was significant difference in the mean IgG levels observed over time (p<0.05), suggesting that different humoral immune response are not necessarily associated with different virus loads observed over time.These results are important because they can help to prevent Conclusions: PCV2 infections using different vaccination schemes to minimize the effect of PCVAD on swine health and production.

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Comparative efficacy of three commercial PCV2 vaccines in conventionally reared pigs

Cited by 31 publications

References 20 publications

Studies on Porcine Circovirus Type 2 Vaccination of 5-Day-Old Piglets

Studies on Porcine Circovirus Type 2 Vaccination of 5-Day-Old Piglets

Antibody Recognition of Porcine Circovirus Type 2 Capsid Protein Epitopes after Vaccination, Infection, and Disease

Longitudinal comparison of the humoral immune response and viral load of Porcine Circovirus Type 2 in pigs with different vaccination schemes under field conditions

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