Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis

Jiang, Xiumin; Luo, Yongxin; Chen, Yiwen; Yan, Jun; Xia, Yucen; Yao, Lin; Wang, Xiaotong; He, Shuangba; Wang, Feixue; Wang, Taiyi; Chen, Yongjun

doi:10.3389/fnbeh.2021.755547

Cited by 11 publications

(14 citation statements)

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“…The primary outcome of efficacy will be defined as mean overall change on continuous depression severity scales. Included systematic reviews or meta-analyses will be required to report at least one of the following indicators: Scores of HRSD, CDRS, CDRS-R, CES-D, BDI, the 9-item patient health questionnaire (PHQ-9), or the Kessler screening scale for psychological distress (K-6) (25). The secondary indicators of this study are as follows.…”

Section: Discussionmentioning

confidence: 99%

“…Pharmacotherapy for SD is mainly with antidepressants such as tricyclics, 5-hydroxytryptamine, reuptake inhibitors, etc. ( 25 ). The effectiveness of pharmacotherapy for SD is varied ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

“…According to different studies, psychotherapy is usually categorized as follows: psychodynamic therapies, cognitive and behavioral therapies (CBT), humanistic therapies, systemic therapies ( 35 ) and interpersonal psychotherapy (IPT) ( 36 ). Each category can also be divided into different types, such as cognitive and behavioral therapies, which contain web-based, bibliotherapy-based and telephone-based cognitive behavioral therapy, and so on ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

“…Several instrumental scales can be used to assess the effect of psychotherapy on SD. Generally speaking, Hamilton Rating Scale for Depression (HRSD) ( 42 ), the Kessler Screening Scale for Psychological Distress (K-6), Beck Depression Inventory scale (BDI), the Patient Health Questionnaire-9 (PHQ-9) and Center for Epidemiologic Studies Depression Scale (CES-D) can often be used as efficacy outcomes for SD ( 25 ). Moreover, Children's Depression Inventory (CDI), Children's Depression Rating Scale (CDRS) or Children's Depression Rating Scale-Revised (CDRS-R) can be used to measure the intervention effect in children ( 34 , 43 ).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of psychotherapy in subthreshold depression patients: A protocol for an overview of systematic reviews and meta-analyses

Han

Yang

et al. 2022

Front. Public Health

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BackgroundSubthreshold depression is a risk factor for major depression. Psychotherapy is a kind of intervention for subthreshold depression. There have been many systematic reviews synthesized the evidence for its effectiveness toward subthreshold depression. However, there is currently no overview of these systematic reviews.ObjectiveTo undertake an overview of meta-analyses and systematic reviews to identify the efficacy of psychotherapy in subthreshold depression patients.MethodsWe will search several databases such as PubMed, Embase, the Cochrane Library, Web of Science, PsycINFO, CNKI, WanFang and VIP database, for systematic reviews and meta-analyses on psychotherapy in subthreshold depression patients. The search timeline will be from inception up to August 2022. Two researchers will screen related studies back-to-back. We will include studies that evaluate the efficacy of psychotherapy in subthreshold depression patients. We will evaluate the methodological quality, the reporting quality and the quality of evidence for outcomes by AMSTAR-2, the PRISMA 2020 checklist and the GRADE grading system. We will present the results of the overview in alignment with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The anticipated start and completion dates for this overview are 1 August 2022 and 30 December 2022, respectively.ResultsFrom this study, we will evaluate the methodological quality and the level of evidence of the included systematic reviews and meta-analyses, and evaluate the efficacy of psychotherapy in patients with subthreshold depression.ImplicationsWe will ascertain the efficacy of psychotherapy in subthreshold depression patients, to provide evidence to guide the treatment of subthreshold depression in the future.Registration numberOur research protocol has been registered with PROSPERO. The registration number of the protocol is CRD42021278871.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of psychotherapy in subthreshold depression patients: A protocol for an overview of systematic reviews and meta-analyses

Han

Yang

et al. 2022

Front. Public Health

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“…The combination of three scales to determine the inclusion criteria of SD has been used in our previous study and other studies ( Jiang et al. , 2020 , 2021 ). All participants were right-handed and had normal or corrected-to-normal vision.…”

Section: Methodsmentioning

confidence: 99%

Neural correlates of negative emotion processing in subthreshold depression

Zhang

et al. 2022

Social Cognitive and Affective Neuroscience

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Subthreshold depression (SD) is regarded as a major risk factor for major depression. However, little is known about the neural mechanism of negative emotion processing in SD. The study aimed to examine the differentiate neural correlates for negative emotion processing in SD and health controls (HC) and to investigate changes in functional connectivity in SD compared with HC. BOLD responses of SD and HC were captured while performing a passive viewing task, which comprised a negative condition and a masked condition. A total of 42 SD and 32 HC adolescents participated the study. Between-group comparisons revealed significant reduced activations in the superior frontal gyrus (SFG), middle frontal gyrus (MFG), and middle cingulate gyrus. Region of interest (ROI) analyses did not find correlations between contrast values of the ROIs and depressive symptoms. In addition, we found significant increased functional connectivity between the SFG and caudate, pallidum, and insula, which were significantly correlated with depressive symptoms in the SD group (P < 0.05). Altered functional connectivity between the SFG and caudate, pallidum, and insula may underlie the pathology of SD. This is the first study to investigate neural mechanisms of negative emotion processing in SD using task-based fMRI.

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Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

Li,

Kuang,

Liu

et al. 2024

Human Brain Mapping

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Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta‐analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate‐based meta‐analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future.

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Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis

Cited by 11 publications

References 72 publications

Efficacy of psychotherapy in subthreshold depression patients: A protocol for an overview of systematic reviews and meta-analyses

Efficacy of psychotherapy in subthreshold depression patients: A protocol for an overview of systematic reviews and meta-analyses

Neural correlates of negative emotion processing in subthreshold depression

Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

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