Comparative efficacy of fixed-dose statin and antihypertensive agent combinations: A network meta-analysis of randomized controlled trials

Bellos, Ioannis; Pergialiotis, Vasilios; Perrea, Despina

doi:10.1016/j.vph.2021.106900

Cited by 4 publications

(2 citation statements)

References 71 publications

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“…These results of article included a larger scope of patients. Besides, the addition of statin was associated with a signi cantly greater reduction of SBP compared with amlodipine monotherapy [32]. A meta-analysis conducted by Ying Wang et al [33] showed that statin group reduced the risk of cardiovascular events compared with non-statin group, similar with our relevant results.…”

Section: Discussionsupporting

confidence: 87%

Effect of Statin use on Patients with Hypertension: A Systematic Review and Meta-analysis

Ding,

Chu,

et al. 2023

Preprint

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Introduction This meta-analysis focused on the effects of statin use (either alone or in combination with antihypertensive drugs) on hypertension-related outcome measures, including systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein-cholesterol (LDL-C), low-density lipoprotein- cholesterol (HDL-C), triglyceride (TG), total cholesterol, TG and total cholesterol. Methods We searched the PubMed, EMBASE, and Cochrane databases before October1 2023.Studies designed as cohort study or randomized controlled trials and investigating the effects of statin use or combined with antihypertensive therapy versus no statin use or antihypertensive therapy alone were included. Authors extracted the data independently; differences were decided to discussion. we use random-effects models to evaluate the merged outcomes. Due to the high heterogeneity of HDL-C group, we performed subgroup analysis according to the type of statin. We use sensitivity analysis, Egger’s test and Funnel plots to evaluate the stability and publication bias of our study. Results 23 trials were included in this meta-analysis. The primary outcomes revealed that (1) administering statins did not significantly impact the SBP of hypertensive patients (MD,-1.77; 95% CI, -4.82 to 1.27). Subgroup analyses revealed a decrease in SBP in patients who received rosuvastatin (MD,-1.70; 95% CI,-2.75 to -0.65) and pravastatin (MD,-8.00; 95% CI,-10.79 to -5.21); (2) no significant effect of statin treatment on DBP in hypertensive patients (MD,-2.04; 95% CI,-4.11 to 0.02). However, subgroup analyses suggest that simvastatin (MD,-2.49; 95% CI, -4.91 to -0.07) and pravastatin (MD,-5.00; 95% CI, -6.60 to -3.40) significantly reduced DBP in hypertensive patients. The secondary outcomes revealed that (1) the use of statins resulted in a significant reduction in LDL-C in hypertensive patients (MD, -0.95; 95% CI, -1.32 to -0.65), while significantly increasing HDL-C (MD, 0.39; 95% CI, 0.15 to 0.64); (2) statins were shown to significantly reduce TG levels in hypertensive patients (MD -0.14, 95% CI -0.23 to -0.05); (3) statins significantly reduced total cholesterol in those hypertensive patients (MD, -1.75; 95% CI, -2.66 to -0.83); (4) statins significantly reduced the incidence of cardiovascular events (HR, 0.73; 95% CI, 0.62 to 0.85) and mortality (HR, 0.47; 95% CI, 0.33 to 0.60). Conclusion Statin use did not modulate SBP and DBP of patients with hypertension, but SBP was decreased in rosuvastatin or pravastatin subgroup and DBP was decreased in simvastatin or pravastatin subgroup. Statin treatment reduced LDL-C, increased HDL-C, reduced TG and total cholesterol, reduced the incidence of cardiovascular events and mortality compared to control groups.

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Section: Discussionsupporting

confidence: 87%

Effect of Statin use on Patients with Hypertension: A Systematic Review and Meta-analysis

Ding,

Chu,

et al. 2023

Preprint

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“…Abebe et al reported a mean difference of 5 mmHg in SBP and 3 mmHg in DBP in the statin group after six months of therapy[13]. Similarly, Danaoğlu et al reported a 23%FIGURE 10:References:[1,15,43,45,46,48]…”

mentioning

confidence: 99%

Statins As Anti-Hypertensive Therapy: A Systematic Review and Meta-Analysis

Khan,

Gul,

Mlawa

et al. 2024

Cureus

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Hypertension is the most prevalent condition in clinical practice. Hypertension, diabetes, and hypercholesterolaemia are major contributing factors to cardiovascular diseases. They commonly coexist in a single patient. Statins have been used as prominent medicines for the reduction of cardiovascular events. Statins have been shown to reduce blood pressure in patients with hypertension and have lipid-lowering properties in recent articles. Statins reduce blood pressure because of their impact on endothelial function, their interactions with the renin-angiotensin system, and their influence on major artery compliance. This meta-analysis aimed to ascertain the effectiveness and efficacy of statins for managing hypertension in patients with hypertension. Systematic searches were conducted on PubMed, Science Direct, Embase, Cochrane Library, and Google Scholar. Randomized controlled trials, systematic trials, and cohort studies were retrieved using keywords on statins and their use in patients with hypertension. Exclusion criteria included studies that were not in the English language, studies that did not include patients on statins with hypertension, studies that did not provide enough information, technical reports, opinions, or editorials, and studies involving patients < 18 years old. The inclusion criteria were randomized controlled trials, meta-analyses, adult patients aged > 18 years old, and studies that were freely available or through institutional login. This meta-analysis scrutinized 9361 randomized controlled trials, clinical trials, meta-analyses, and systematic reviews, of which 32 articles including 25 randomized controlled trials and seven meta-analyses were included in the final analysis. This meta-analysis of the role of statins in hypertensive patients aimed to determine the outcome of hypertension control along with antihypertensive medication. Our study showed that statins are useful in reducing both systolic and diastolic blood pressure. We used a heterogeneous model for analysis due to variations in the study characteristics. The I2 value was 0.33 (0.76, 0.10) for systolic blood pressure and 0/88 (0.86, 0.90) for diastolic blood pressure. The I2 value for the seven meta-analyses included in the study was 1.79 (2.88, 0.69).

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Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up

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D’Addato

Fogacci

et al. 2022

Nutrition, Metabolism and Cardiovascular Diseases

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Comparative efficacy of fixed-dose statin and antihypertensive agent combinations: A network meta-analysis of randomized controlled trials

Cited by 4 publications

References 71 publications

Effect of Statin use on Patients with Hypertension: A Systematic Review and Meta-analysis

Effect of Statin use on Patients with Hypertension: A Systematic Review and Meta-analysis

Statins As Anti-Hypertensive Therapy: A Systematic Review and Meta-Analysis

Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up

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