Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up

Cicero, Arrigo F G; D’Addato, Sergio; Fogacci, Federica; Giovannini, Marina; Borghi, Claudio; Rizzoli, Elisabetta; Ventura, Fulvio; Coppola, Paolo Elia; Ianniello, Eugenia; Soldati, Mario; Piani, Federica Mariasole; Iamino, Ilaria Ricci; Palmisano, Silvia; Landolfo, Matteo; Bacchelli, Stefano; Borghi, Claudio

doi:10.1016/j.numecd.2022.06.017

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…A Cicero et al evaluated added statins to ACE inhibitors on CVD outcomes in Brisighella Heart Study (8-year follow-up). Authors concluded that combined treatment with ACE inhibitors and atorvastatin in hypertensive patients significantly reduce the risk of developing CVD in compared with treatment with ACE inhibitors alone [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“The impact of statins addind to the fixed combination antihypertensive therapy on the arterial stiffness in patients with moderate and severe hypertension"

Sіrenko

Rekovets

2023

International Journal of Cardiology Cardiovascular Risk and Pre

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Section: Discussionmentioning

confidence: 99%

“The impact of statins addind to the fixed combination antihypertensive therapy on the arterial stiffness in patients with moderate and severe hypertension"

Sіrenko

Rekovets

2023

International Journal of Cardiology Cardiovascular Risk and Pre

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“…Kandungan mineral pada penelitian ini masih tergolong rendah dibandingkan dengan penelitian-penelitian sebelumnya pada spesies Archachatina marginata (Djikeng et al, 2022), Laevistrombus turturella (867,81 mg/100g) berat kering dan Hemifusus colosseus (639,4 mg/100g) (Rasyid & Dody, 2018;Thu et al, 2020). Selain itu, makro mineral yang penting untuk pemenuhan nutrisi pada manusia seperti selenium (Se), tembaga (Cu), dan seng (Zn) juga dapat diakumulasi dengan jumlah banyak dalam tubuh gastropoda (Ziomek et al, 2018;Vukašinović-Pešić et al, 2020;Cicero et al, 2022). Gastropoda laut Monetaria dan Lambis juga dilaporkan mengandung mikro mineral seperti Mn, Fe, Cu, dan Zn (Warsidah et al, 2022).…”

Section: Kandungan Nutrisi Gastropoda DI Kawasan Mangrove Desa Bakauunclassified

Proximate and Macromineral Content of Gastropods in the Mangrove Area of Desa Bakau Sambas Regency

Warsidah,

Safitri,

Sofiana

et al. 2024

JIP

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Gastropods are the largest class of the phylum mollusks, with 75,000 identified species. Gastropods are widely distributed in freshwater, marine waters, and mangrove ecosystems. Gastropods are a fishery commodity with an important economic value containing high protein (36-70.8%) and low fat (0.02-1.50%). This biota has vitamins, essential minerals, omega-3, and omega-6. This research aimed to determine the proximate content (protein, fat, water, ash, and carbohydrates) and macrominerals (Na, K, Mg, Ca, and P) in gastropods found in Bakau Village, Sambas Regency, West Kalimantan. The gastropods found were Ellobium, Cerithidea, and Pirenella. Fifty individuals were taken for proximate analysis. Moisture and ash content were determined by the gravimetric method. Total protein levels were analyzed by the Kjedahl method. The fat content was determined by the Soxhlet method, and the carbohydrate content by the by difference method. Atomic Absorption Spectrophotometer determined mineral macro. The proximate content of mangrove gastropods in Bakau Village is high in protein (48.06–54.62%) and low in fat (1.31–7.40%). The most elevated protein was 54.62 in Ellobium and Pirenella, with the lowest fat being 1.31%. The macro mineral content in gastropods is Ca (14.91-91.48 mg/kg), Mg (13.16-21.74 mg/kg), Na (8.19-20.62 mg/kg), K (13.07-17.33 mg/kg), and P (0.66-0.71 mg/kg). The highest mineral content was shown by the genus Pirenella (91.48 mg/kg) Ca. Keywords: gastropod, macromineral, mangrove, proximate. Abstrak Gastropoda adalah kelas terbesar dari filum moluska dengan 75.000 jenis yang telah teridentifikasi. Gastropoda terdistribusi luas di perairan tawar, perairan laut, dan ekosistem mangrove. Gastropoda merupakan salah satu komoditas perikanan dengan nilai ekonomis penting yang mengandung protein tinggi (36-70,8%) dan lemak yang rendah (0,02-1,50%). Biota ini juga memiliki vitamin, mineral esensial, omega-3 dan omega-6. Penelitian ini bertujuan untuk mengetahui kandungan proksimat (protein, lemak, air, abu, dan karbohidrat) serta makromineral (Na, K, Mg, Ca, dan P) pada gastropoda yang ditemukan di Desa Bakau, Kabupaten Sambas, Kalimantan Barat. Gastropoda yang ditemukan pada penelitian ini adalah Ellobium, Cerithidea, dan Pirenella. Setiap jenis dari gastropoda, masing-masing diambil sebanyak 50 individu untuk dilakukan analisis. Kadar air dan abu ditentukan dengan metode gravimetri. Kadar total protein dianalisis dengan metode Kjedahl. Kadar lemak ditentukan dengan metode soxhlet dan kadar karbohidrat dengan metode by difference. Makro mineral ditentukan dengan Spektrofotometer Serapan Atom. Kandungan proksimat dari jenis gastropoda mangrove Desa Bakau adalah tinggi protein (48,06–54,62%), rendah lemak (1,31–7,40%). Protein tertinggi 54,62 pada Ellobium dan Pirenella dengan lemak terendah 1,31%. Kandungan makro mineral pada gastropoda adalah Ca (14,91-91,48 mg/kg), Mg (13,16-21,74 mg/kg), Na (8,19-20,62 mg/kg), K (13,07-17,33 mg/kg), dan P (0,66-0,71 mg/kg). Kandungan mineral tertinggi ditunjukkan oleh genus Pirenella (91,48 mg/kg) Ca. Kata kunci: gastropoda, makromineral, mangrove, proksimat.

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“…Рациональность, эффективность и безопасность комбинаторики трёх пролонгированных, умеренно Российский кардиологический журнал 2024; 29 (3) липофильных и органопротекторных ингредиентов со взвешенно подобранным режимом дозирования, входящих в состав лекарственного препарата "Липертанс" (амлодипин, аторвастатин, периндоприла аргинин), была доказана в ходе восьмилетнего наблюдения за когортой больных с сердечнососудистой патологией, нуждающихся в назначении вазопротекторной, антигипертензивной, антиишемической и гиполипидемической терапии. В реальной клинической практике свободная комбинация указанных лекарственных средств лучше других препаратов зарекомендовала себя для 24-часового контроля артериального давления и длительного поддержания липидограммы в целевых значениях, что отразилось на уменьшении потребности видоизменять ранее подобранную терапию, а также закономерно сказалось на значимом снижении числа сердечнососудистых катастроф [34].…”

Section: амлодипин (связь с белками 97%unclassified

Contribution of lipophilicity to the clinical effects of drugs

Skotnikov,

Melnik,

Zinina

et al. 2024

Russ J Cardiol

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The article is devoted to a detailed analysis of the action of various drugs used in the treatment of hypertension and atherogenic dyslipidemia, depending on their ability to dissolve in fatty media (lipophilicity). The authors analyze connection between the lipophilicity level of drugs and their pharmacokinetics, drug-drug interactions, the manifestations of clinical effects and organ protection, as well as their ability to influence the prognosis of comorbid patients. Using angiotensin-converting enzyme inhibitors, calcium channel blockers, and statins as examples, the authors explain the practical significance of pharmacological parameters such as plasma protein binding and distribution volume, and also develop an understanding of the importance of its routine use in order to obtain clinical benefits for patients.

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Impact of simultaneous management of hypertension and hypercholesterolemia with ACE inhibitors and statins on cardiovascular outcomes in the Brisighella Heart Study: A 8-year follow-up

Cited by 4 publications

References 26 publications

“The impact of statins addind to the fixed combination antihypertensive therapy on the arterial stiffness in patients with moderate and severe hypertension"

“The impact of statins addind to the fixed combination antihypertensive therapy on the arterial stiffness in patients with moderate and severe hypertension"

Proximate and Macromineral Content of Gastropods in the Mangrove Area of Desa Bakau Sambas Regency

Contribution of lipophilicity to the clinical effects of drugs

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