Comparative efficacy of 6 traditional Chinese patent medicines combined with lifestyle modification in patients with prediabetes: A network meta-analysis

Li, Jiang; Zhang, Yaofu; Zhang, Hua; Chen, Yu; Huang, Weijun; Xiao, Yao; Shen, Esther Aijia; Li, Zhuang; Xue, Taiqi; Zhao, Jinxi; Wang, Shidong

doi:10.1016/j.diabres.2022.109878

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Chinese traditional medicine possesses distinct advantages in the treatment of various diseases. While certain medications, such as Tianqi capsule, Jin qi jiang tang tablet, and Jin li da granule, have demonstrated efficacy in remission/reversal of prediabetes ( 106 ), limited research exists on their effectiveness in remission of clinical diabetes. Consequently, further investigation is warranted to explore mitigation strategies tailored to the Chinese population, with particular emphasis on harnessing the unique attributes of traditional Chinese medicine for the treatment and remission of diabetes.…”

Section: Discussionmentioning

confidence: 99%

Global research trends of diabetes remission: a bibliometric study

Yang,

He,

Chen

et al. 2023

Front. Endocrinol.

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BackgroundResearch on diabetes remission has garnered prominence in recent years. However, to date, no pertinent bibliometric study has been published. This study sought to elucidate the current landscape and pinpoint potential new research directions through a bibliometric analysis of diabetes remission.MethodsWe perused relevant articles on diabetes remission from January 1, 2000, to April 16, 2023, in the Web of Science. We utilized CiteSpace software and VOSviewer software to construct knowledge maps and undertake analysis of countries, institutional affiliations, author contributions, journals, and keywords. This analysis facilitated the identification of current research foci and forecasting future trends.ResultsA total of 970 English articles were procured, and the annual publication volume manifested a steady growth trend. Most of the articles originated from America (n=342, 35.26%), succeeded by China and England. Pertaining to institutions, the University of Newcastle in England proliferated the most articles (n=36, 3.71%). Taylor R authored the most articles (n=35, 3.61%), and his articles were also the most co-cited (n=1756 times). Obesity Surgery dominated in terms of published articles (n=81, 8.35%). “Bariatric surgery” was the most prevalently used keyword. The keyword-clustering map revealed that the research predominantly centered on diabetes remission, type 1 diabetes, bariatric surgery, and lifestyle interventions. The keyword emergence and keyword time-zone maps depicted hotspots and shifts in the domain of diabetes remission. Initially, the hotspots were primarily fundamental experiments probing the feasibilities and mechanisms of diabetes remission, such as transplantation. Over the course, the research trajectory transitioned from basic to clinical concerning diabetes remission through bariatric surgery, lifestyle interventions, and alternative strategies.ConclusionOver the preceding 20 years, the domain of diabetes remission has flourished globally. Bariatric surgery and lifestyle interventions bestow unique advantages for diabetes remission. Via the maps, the developmental milieu, research foci, and avant-garde trends in this domain are cogently portrayed, offering guidance for scholars.

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Section: Discussionmentioning

confidence: 99%

Global research trends of diabetes remission: a bibliometric study

Yang,

He,

Chen

et al. 2023

Front. Endocrinol.

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“…TCM and other natural drugs have strong pharmacological activity, with anti-inflammatory, antioxidant, antidiabetic, and other effects ( 73 ). Many types of TCM were included in this study, such as salvia, red peony root, and other blood-activating drugs, which have been proven to maintain blood glucose levels and reduce the content of HbA1c ( 74 ). Kudzu root, coptis and rhizome can improve glucose uptake and utilization.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of traditional Chinese medicines combined with conventional Western medicines in the treatment of type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials

Zhou

Yao

et al. 2023

Front. Endocrinol.

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Aims/hypothesisThrough a comprehensive analysis of the clinical randomized controlled trials of traditional Chinese medicine (TCM) combined with conventional western medicine (CWM) in treating type 2 diabetes(T2DM) in the past ten years, the clinical efficacy and safety of different TCMs combined with CWM were explored. This study aimed to provide specific suggestions for clinical guidance on treating T2DM.MethodsA literature search was conducted in CNKI, WanFang, VIP, CBM, PubMed, Embase, and Web of Science. The search time was limited from 2010 to the present time. The literature type was a controlled clinical trial study of TCM combined with CWM intervention in treating T2DM. The outcome indices of the efficacy evaluation included fasting blood glucose (FBG), 2-hour postprandial blood glucose (2hPG), glycosylated hemoglobin (HbA1c), adverse reactions, and clinical efficacy. Stata 15 and RevMan 5.4 software were used to conduct a network meta-analysis and a traditional meta-analysis.ResultsThe results showed that shenqi jiangtang granule combined with sulfonylurea, shenqi jiangtang granules combined with metformin and jinlida granules combined with insulin had significant effects on reductions in FBG, 2hPG and clinical efficacy compared with western medicines alone, which included fasting blood glucose [MD=-2.17, 95%CI=(-2.50, -1.85)], blood sugar at 2 hours after a meal [MD=-1.94, 95%CI=(-2.23, -1.65)], and clinical curative effect [OR= 1.73, 95%CI=(0.59, 2.87)].ConclusionsTCM combined with CWM has a very significant effect on treating T2DM compared with CWM alone. According to the network meta-analysis, the best intervention measures of different TCMs for different outcome indicators were obtained.Systematic review registrationidentifier 42022350372.

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“…Clinical studies have recently revealed that Traditional Chinese Patent Medicines (TCPM) played a positive role in improving the lipid profile and relieving symptoms of prediabetes. So, several TCPMs have been clearly recommended as the important intervention for prediabetes in Chinese domestic guidelines ( Endocrinology and Metabolic Diseases Committee of the Chinese Physicians Association, Integrated Chinese and Western Medicine Branch, 2021 ; Chinese Diabetes Society, 2021 ), which are namely Shen qi jiang tang capsule/granule (Shenqi), Tian mai xiao ke tablet (Tianmai), Tian qi jiang tang capsule (Tianqi), Jin qi jiang tang tablet (Jinqi), Jin li da granule (Jinlida), and Tang mai kang granule (Tangmaikang) ( Jiang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…The included TCPM all followed the basic understanding of traditional context and contained mainly herbs that have the effect of clearing Fire and benefiting Qi, thus showing some positive significance in clinical research studies and getting recommended in experts’ advice and official guidelines ( Xia et al, 2020 ). Until now, although there were some meta-analyses focusing on the clinical effectiveness and safety of TCPM for treating prediabetes ( Pang et al, 2017 ; Pang et al, 2018 ; Jiang et al, 2022 ), the general shortcomings still existed: 1) the main outcome was blood glucose indicators, such as glycosylated hemoglobin, FBG, and PBG, with insufficient emphasis on lipids. 2) The number of literatures covered was limited, the sample size was insufficient, and the heterogeneity among different comparisons was large; 3) in recent add-on research studies, there was still a lack of comparative efficacy between the various types of TCPM.…”

Section: Introductionmentioning

confidence: 99%

Treatment options of traditional Chinese patent medicines for dyslipidemia in patients with prediabetes: A systematic review and network meta-analysis

Wang²,

Zhao³

et al. 2022

Front. Pharmacol.

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Objective: To compare the clinical efficacy and safety of SIX Traditional Chinese Patent Medicines (TCPM) recommended by guidelines in improving lipids for patients with prediabetes by network meta-analysis.Methods: Randomized controlled trials of 6 TCPM in the treatment of prediabetes were searched systematically in various databases. After extracting effective data, the risk of bias was assessed using Review Manager 5.3 and Cochrane Collaboration Systems Evaluator’s Manual. Network meta-analysis was performed using STATA 15.0 based on the frequency statistical model. The effect size and credibility of the evidence for the intervention were summarized based on a minimal contextualized framework.Results: A total of 27 studies involving 2,227 patients were included. Compared with lifestyle modification (LM), Shenqi + LM [SMD −0.49 (95% CI: −0.85, −0.12)] and Jinqi + LM [SMD −0.44 (95% CI: −0.81, −0.06)] showed statistically significant effect in lowering TG, Shenqi + LM [SMD −0.51 (95%CI: −0.86, −0.17)] and Jinqi + LM [SMD −0.44 (95%CI: −0.80, −0.08)] in lowering TC, Jinlida + LM [SMD −0.31 (95%CI: −0.59, −0.04)] in lowering LDL-C, Shenqi + LM [SMD 0.29 (95%CI: 0.06, 0.51)] and Jinqi + LM [SMD 0.16 (95%CI: 0.01, 0.31)] in increasing HDL-C.Conclusion: For patients with prediabetes, Traditional Chinese patent medicine Jinqi and Shenqi combined with lifestyle modification were associated with a significant reduction in TG and TC, while Shenqi + LM was among the most effective. Jinlida + LM was among the least effective.Systematic Review Registration:https://clinicaltrials.gov/, identifier PROSPERO(CRD42021279332).

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Comparative efficacy of 6 traditional Chinese patent medicines combined with lifestyle modification in patients with prediabetes: A network meta-analysis

Cited by 5 publications

References 24 publications

Global research trends of diabetes remission: a bibliometric study

Global research trends of diabetes remission: a bibliometric study

Efficacy and safety of traditional Chinese medicines combined with conventional Western medicines in the treatment of type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials

Treatment options of traditional Chinese patent medicines for dyslipidemia in patients with prediabetes: A systematic review and network meta-analysis

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