Comparative efficacy and safety of non-polymyxin antibiotics against nosocomial pneumonia, complicated intra-abdominal infection, or complicated urinary tract infection: A network meta-analysis of randomised clinical trials

Lin, Meng-Hsuan; Shen, Yi‐Cheng; Cheng, Heyong; Teng, Chi-Kang; Chen, Wei-Cheng; Lin, Yu-Chao; Hung, Chin‐Chuan

doi:10.1016/j.jgar.2023.05.011

Cited by 2 publications

(2 citation statements)

References 71 publications

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“…Meta-analysis of clinical trials and case reports found good safety profiles for systemic use of cefiderocol, suggesting that it will be well tolerated with topical use. 41 , 42 However, systematic studies of safety for topical treatment are necessary. Although mutations that diminish cefiderocol efficacy occur, resistance remains rare among systemic isolates of P. aeruginosa .…”

Section: Discussionmentioning

confidence: 99%

Cefiderocol Is an Effective Topical Monotherapy for Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis

Romanowski,

Mumper,

Shanks

et al. 2024

Ophthalmology Science

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Section: Discussionmentioning

confidence: 99%

Cefiderocol Is an Effective Topical Monotherapy for Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis

Romanowski,

Mumper,

Shanks

et al. 2024

Ophthalmology Science

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“…A recent network meta-analysis of RCTs has identified cefiderocol as one of the leading treatment options for cUTIs, especially when considering p-value analysis within the subgroup of cUTI infections [87]. This is further supported by recommendations from The Infectious Diseases Society of America, which has singled out cefiderocol as the treatment of choice for cUTIs caused by CRE that show resistance to both ertapenem and meropenem [88].…”

Section: Cefiderocolmentioning

confidence: 99%

Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives

Bologna,

Licari,

Manfredi

et al. 2024

Medicina

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Urinary tract infections (UTIs) are the second most frequent type of infection observed in clinical practice. Gram-negative Enterobacteriaceae are common pathogens in UTIs. Excessive antibiotic use in humans and animals, poor infection control, and increased global travel have accelerated the spread of multidrug-resistant strains (MDR). Carbapenem antibiotics are commonly considered the last line of defense against MDR Gram-negative bacteria; however, their efficacy is now threatened by the increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE). This comprehensive review aims to explore the biological mechanisms underlying carbapenem resistance and to present a focus on therapeutic alternatives currently available for complicated UTIs (cUTIs). A comprehensive bibliographic search was conducted on the PubMed/MEDLINE, Scopus, and Web of Science databases in December 2023. The best evidence on the topic was selected, described, and discussed. Analyzed with particular interest were the clinical trials pivotal to the introduction of new pharmacological treatments in the management of complicated cUTIs. Additional suitable articles were collected by manually cross-referencing the bibliography of previously selected papers. This overview provides a current and comprehensive examination of the treatment options available for CRE infections, offering a valuable resource for understanding this constantly evolving public health challenge.

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Comparative efficacy and safety of non-polymyxin antibiotics against nosocomial pneumonia, complicated intra-abdominal infection, or complicated urinary tract infection: A network meta-analysis of randomised clinical trials

Cited by 2 publications

References 71 publications

Cefiderocol Is an Effective Topical Monotherapy for Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis

Cefiderocol Is an Effective Topical Monotherapy for Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis

Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives

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