Comparative effects of vitamin D and vitamin C supplementations with and without endurance physical activity on metabolic syndrome patients: a randomized controlled trial

Farag, Halgord Ali M.; Hosseinzadeh‐Attar, Mohammad Javad; Muhammad, Belal A.; Esmaillzadeh, Ahmad; Bilbeisi, Abdel Hamid El

doi:10.1186/s13098-018-0384-8

Cited by 17 publications

(25 citation statements)

References 53 publications

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“…Their data concluded that subjects taking vitamin C alone had a lowered TG level compared to placebo. The level of HDL-C was increased, but TG and waist circumference were decreased in MetS patients subjected to vitamin C supplementation with exercise in relative to the placebo [50]. Another randomised double-blind, placebo-controlled trial by the same group of researchers involved 96 MetS patients aged between 30 to 60 years old.…”

Section: The Effects Of Vitamin C Supplementation On Metsmentioning

confidence: 99%

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Wong

Chin

2020

Int. J. Med. Sci.

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Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In vivo studies showed promising effects of vitamin C, but most of the interventions used were in combination with other compounds. The direct effects of vitamin C remain to be elucidated. In humans, the current state of evidence revealed that lower vitamin C intake and circulating concentration were found in MetS subjects. A negative relationship was observed between vitamin C intake / concentration and the risk of MetS. Oral supplementation of vitamin C also improved MetS conditions. It has been postulated that the positive outcomes of vitamin C may be in part mediated through its anti-oxidative and anti-inflammatory properties. These observations suggest the importance of MetS patients to have an adequate intake of vitamin C through food, beverages or supplements in order to maintain its concentration in the systemic circulation and potentially reverse MetS.

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Section: The Effects Of Vitamin C Supplementation On Metsmentioning

confidence: 99%

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Wong

Chin

2020

Int. J. Med. Sci.

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“…Vitamin B7, biotin deficiency has been linked to impaired glucose tolerance, hyperglycemia, and decreased glucose oxidation in animal studies [ 168 ] and a cross-sectional study showed that high levels of vitamin B12 are protective to MetS [ 169 ]. Regarding vitamin C, different patient-based studies have suggested that intake or supplementation decreases the risk of MetS and improves the quality of life of MetS patients [ 169 , 170 ], especially when combined with physical exercise [ 171 , 172 ]. Moreover, a cross-sectional study with more than 2000 patients demonstrated that deficiency of vitamin C was associated with an increased likelihood of MetS [ 169 ].…”

Section: Nutrients (Well-being Through Feeding)mentioning

confidence: 99%

Nutrition, Bioenergetics, and Metabolic Syndrome

et al. 2020

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According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world’s population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden.

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“…Assessment of anthropometric measurements: Height (m), weight (kg), and waist circumference (WC) were measured according to standard [27]. In addition, the body mass index (BMI) was calculated by dividing weight in kilograms by the square of height in meters.…”

Section: Methodsmentioning

confidence: 99%

Dietary Patterns and Their Association with Depression among Type 2 Diabetes Patients in Gaza Strip, Palestine

Bilbeisi¹,

Srour²,

Afifi³

et al. 2019

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Background: Depression is a common mental disorder. Globally, more than 340 million people of all ages suffer from depression. The aim of our study was to determine the association between major dietary patterns and depression among type 2 diabetes patients. Methods: This cross-sectional study was conducted among 480 type 2 diabetes patients attending primary healthcare centers in Gaza Strip, Palestine. The depression, anxiety, stress scales (DASS, 21-items) questionnaire was used to measure the score of depression. The participants' demographic, socioeconomic and medical history data was collected and the 98-items semi-quantitative food frequency questionnaire was used for evaluating the dietary patterns. Statistical analysis was performed using SPSS version 20. Results: Based on depression scale, 29.0% of type 2 diabetes patients had depression, (58.3% females, and 41.7% males). The prevalence of mild, moderate, severe, and very severe depression was 11.7%, 8.5%, 6.7%, and 2.1%, respectively. Furthermore, two major dietary patterns were identified by factor analysis: The Western, and the grains-vegetables, and fruits patterns. After adjusting for the potential confounders, patients in the lowest tertile (T1) of the grains-vegetables, and fruits dietary pattern had a lower odds for depression (OR 0.763 95% CI (0.667-0.871), P value = 0.001); where as a higher odds for healthy (OR 1.443 95% CI (1.131-1.839), P value = 0.004), compared to those in the highest tertile (T3). Conclusion: The grains-vegetables, and fruits dietary pattern may be associated with a lower prevalence of depression, and has been shown to be the healthiest dietary

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Comparative effects of vitamin D and vitamin C supplementations with and without endurance physical activity on metabolic syndrome patients: a randomized controlled trial

Cited by 17 publications

References 53 publications

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Nutrition, Bioenergetics, and Metabolic Syndrome

Dietary Patterns and Their Association with Depression among Type 2 Diabetes Patients in Gaza Strip, Palestine

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