Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles

Santacruz-Márquez, Ramsés; Solorio-Rodríguez, A.; González-Posos, Sirenia; García-Zepeda, Sihomara Patricia; Santoyo-Salazar, J.; Vizcaya-Ruiz, Andrea De; Hernández‐Ochoa, Isabel

doi:10.1016/j.reprotox.2020.08.003

Cited by 11 publications

(17 citation statements)

References 59 publications

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“…However, ZnO NPs, which were partially dissolved in the culture medium, reduced follicle diameter and disrupted cytoskeleton arrangement, without being blocked by Trolox (Figure 10c,d). [ 233 ] In addition, Kuang et al found that ZnO NPs could activate mitochondria‐mediated signaling pathways and induce caspase‐dependent damage to the uterus. [ 231 ] Hence, the ovarian follicular toxicity induced by different metal‐based NPs may be due to different toxicity mechanisms.…”

Section: Cytotoxicity Of Metal‐based Npsmentioning

confidence: 99%

“…[ 231 ] Hence, the ovarian follicular toxicity induced by different metal‐based NPs may be due to different toxicity mechanisms. [ 233 ]…”

Section: Cytotoxicity Of Metal‐based Npsmentioning

confidence: 99%

“…c,d) Representative micrographs of TiO 2 and ZnO NP effects on cytoskeletal organization in theca cells after culture with or without Trolox. Reproduced with permission [233]. Copyright 2020, Elsevier.…”

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confidence: 99%

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Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations

Xiong

Xiao-hong

et al. 2022

Advanced Science

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Metal-based nanoparticles (NPs) are particularly important tools in tissue engineering-, drug carrier-, interventional therapy-, and biobased technologies. However, their complex and varied migration and transformation pathways, as well as their continuous accumulation in closed biological systems, cause various unpredictable toxic effects that threaten human and ecosystem health. Considerable experimental and theoretical efforts have been made toward understanding these cytotoxic effects, though more research on metal-based NPs integrated with clinical medicine is required. This review summarizes the mechanisms and evaluation methods of cytotoxicity and provides an in-depth analysis of the typical effects generated in the nervous, immune, reproductive, and genetic systems. In addition, the challenges and opportunities are discussed to enhance future investigations on safer metal-based NPs for practical commercial adoption.

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Section: Cytotoxicity Of Metal‐based Npsmentioning

confidence: 99%

“…[ 231 ] Hence, the ovarian follicular toxicity induced by different metal‐based NPs may be due to different toxicity mechanisms. [ 233 ]…”

Section: Cytotoxicity Of Metal‐based Npsmentioning

confidence: 99%

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Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations

Xiong

Xiao-hong

et al. 2022

Advanced Science

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“…Through in vivo experiments, Schadlich et al detected the accumulation of nanoparticles, nanocapsules and nanolipid emulsions at specific locations in mouse ovaries [ 313 ]. Moreover, evidence accumulated from in vivo and in vitro models has suggested that the accumulation of nanoparticles in the ovary could an impair ovarian function by affecting sex hormone synthesis [ 314 , 315 ], follicular development [ 31 , 316 ] and oocyte quality [ 317 , 318 ]. Therefore, the ovarian toxicity of NPs should be considered when selecting materials for the diagnosis and treatment of ovarian aging and a better examination of the ovarian toxicity of NPs will help to improve NPs regulation and design safer NPs.…”

Section: Practical Challenges With Biomaterials For the Clinical Eval...mentioning

confidence: 99%

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Guo

Wei

et al. 2022

J Nanobiotechnol

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Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation. Graphical Abstract

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“…Toxicity of the ovarian follicles was induced by TiO 2 NPs through entry and accumulation in cells and increase in the follicular diameter, and by ZnO NPs via decreasing follicular diameter. Also, both nanoparticles led to degradation of cytoskeletal arrangement and ultrastructural changes such as incomplete transzonal projection and mitochondrial swelling [47].…”

Section: Zinc Nanoparticlesmentioning

confidence: 99%

The Effects of Metal Nanoparticles on the Mammalian Reproductive System

Lohrasbi¹,

Bahmanpour²

2021

Nano BioMed ENG

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Due to the increasing use of nanoparticles in medical and industrial fields, concerns are growing about the toxicity of them to the body organs especially the reproductive system. In this review, the effect of metal/metal oxide nanoparticles on the mammalian reproductive system was discussed. Nanoparticles are typically toxic to both males and females, depending on their types, administration method, exposure duration, and surface modification. Regarding the embryo, it was also found that the effect of nanoparticles depends on the embryonic stage exposure during development. However, some nanoparticles, depending on the dose and time of administration, not only did not have toxic effects, but also strengthened the reproductive system and increased its efficiency. As the mode of interaction, penetration, and mechanism of nanoparticles action in the reproductive system is unclear, this review highlights the importance of additional tests in these cases.

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Comparative effects of TiO2 and ZnO nanoparticles on growth and ultrastructure of ovarian antral follicles

Cited by 11 publications

References 59 publications

Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations

Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

The Effects of Metal Nanoparticles on the Mammalian Reproductive System

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